Molecular Nutrition and Mitochondria: Metabolic Deficits, Whole-Diet Interventions, and Targeted Nutraceuticals provides a comprehensive examination of molecular aspects of mitochondrial nutrition and how dietary compounds might impact the treatment of mitochondrial dysfunction.
Beginning with an overview of the fundamentals of mitochondria physiology and the methods used to evaluate mitochondrial imbalance in clinical practice, the book goes on to outline nutritional shortfalls in mitochondrial dysfunction and highlights the complex intra-organelle milieu affecting interactions between food compounds and mitochondrial co-factors, metabolites, and signaling molecules. Further sections explore the impact of essential nutrients, such as vitamin E, fatty acids, and complex lipids, on mitochondrial biogenesis, as well as non-essential bioactive compounds originating from food that can be evaluated for their mitochondria-modulating potential, such as mitochondria-targeted small molecule antioxidants, plant-based pigments and organic compounds, nucleotides, non-proteogenic amino acids and derivatives, and mitochondria-specific enzyme mimetics from food.
Molecular Nutrition and Mitochondria covers the key impacts of nutrition on mitochondria, and is the ideal reference for researchers, students and clinicians looking to develop an in-depth understanding of how dietary compounds can prevent and treat disorders associated with mitochondrial dysfunction.
1. Molecular Nutrition and Mitochondria - p. ii 2. Cover - p. ii 3. Title Page - p. ii 4. Copyright - p. iv 5. Table of Contents - p. iv 6. List of Contributors - p. xix 7. Preface - p. xxv 8. Acknowledgments - p. xxvii 9. Chapter 1 Targeting mitochondrial dysfunction with nutrients: challenges and opportunities - p. 3 10. Chapter 2 Mitochondrion at the crossroads between nutrients and the epigenome - p. 71 11. Chapter 3 Nutritional assessment and malnutrition in adult patients with mitochondrial disease - p. 93 12. Chapter 4 Therapeutic potential and metabolic impact of alternative respiratory chain enzymes - p. 105 13. Chapter 5 Aging, mitochondrial dysfunctions, and vitamin E - p. 131 14. Chapter 6 The role of B vitamins in protecting mitochondrial function - p. 167 15. Chapter 7 Analysis of the mitochondrial status of murine neuronal N2a cells treated with resveratrol and synthetic isomeric resveratrol analogs: aza-stilbenes - p. 195 16. Chapter 8 Dietary eicosapentaenoic acid and docosahexaenoic acid for mitochondrial biogenesis and dynamics - p. 213 17. Chapter 9 Vitamin C and mitochondrial function in health and exercise - p. 225 18. Chapter 10 Roles of dietary fiber and gut microbial metabolites short-chain fatty acids in regulating mitochondrial function in central nervous system - p. 243 19. Chapter 11 Mitochondria-targeted antioxidants: coenzyme Q10, mito-Q and beyond - p. 255 20. Chapter 12 Flavonoids, mitochondrial enzymes and heart protection - p. 303 21. Chapter 13 Tea polyphenols stimulate mt bioenergetics in cardiometabolic diseases - p. 333 22. Chapter 14 A review of quercetin delivery through nanovectors: cellular and mitochondrial effects on noncommunicable diseases - p. 363 23. Chapter 15 Creatine monohydrate for mitochondrial nutrition - p. 383 24. Chapter 16 Arginine and neuroprotection: a focus on stroke - p. 417 25. Chapter 17 Nutraceuticals for targeting NAD+ to restore mitochondrial function - p. 433 26. Chapter 18 Curcumin for protecting mitochondria and downregulating inflammation - p. 461 27. Chapter 19 Dihydrogen as an innovative nutraceutical for mitochondrial viability - p. 501 28. Chapter 20 Fucoxantin and mitochondrial uncoupling protein 1 in obesity - p. 513 29. Chapter 21 Rice bran extract for the prevention of mitochondrial dysfunction - p. 521 30. Chapter 22 Silymarin as a vitagene modulator: effects on mitochondria integrity in stress conditions - p. 535 31. Chapter 23 Buckwheat trypsin inhibitors: novel nutraceuticals for mitochondrial homeostasis - p. 561 32. Chapter 24 Diet restriction-induced mitochondrial signaling and healthy aging - p. 587 33. Chapter 25 Rejuvenation of mitochondrial function by time-controlled fasting - p. 633 34. Chapter 26 Dietary modulation and mitochondrial DNA damage - p. 651 35. Index - p. 667 36. Index - Continued - p. 680
Molecular Nutrition and Mitochondria: Metabolic Deficits, Whole-Diet Interventions, and Targeted Nutraceuticals provides a comprehensive examination of molecular aspects of mitochondrial nutrition and how dietary compounds might impact the treatment of mitochondrial dysfunction.
Beginning with an overview of the fundamentals of mitochondria physiology and the methods used to evaluate mitochondrial imbalance in clinical practice, the book goes on to outline nutritional shortfalls in mitochondrial dysfunction and highlights the complex intra-organelle milieu affecting interactions between food compounds and mitochondrial co-factors, metabolites, and signaling molecules. Further sections explore the impact of essential nutrients, such as vitamin E, fatty acids, and complex lipids, on mitochondrial biogenesis, as well as non-essential bioactive compounds originating from food that can be evaluated for their mitochondria-modulating potential, such as mitochondria-targeted small molecule antioxidants, plant-based pigments and organic compounds, nucleotides, non-proteogenic amino acids and derivatives, and mitochondria-specific enzyme mimetics from food.
Molecular Nutrition and Mitochondria covers the key impacts of nutrition on mitochondria, and is the ideal reference for researchers, students and clinicians looking to develop an in-depth understanding of how dietary compounds can prevent and treat disorders associated with mitochondrial dysfunction.
1. Molecular Nutrition and Mitochondria - p. ii 2. Cover - p. ii 3. Title Page - p. ii 4. Copyright - p. iv 5. Table of Contents - p. iv 6. List of Contributors - p. xix 7. Preface - p. xxv 8. Acknowledgments - p. xxvii 9. Chapter 1 Targeting mitochondrial dysfunction with nutrients: challenges and opportunities - p. 3 10. Chapter 2 Mitochondrion at the crossroads between nutrients and the epigenome - p. 71 11. Chapter 3 Nutritional assessment and malnutrition in adult patients with mitochondrial disease - p. 93 12. Chapter 4 Therapeutic potential and metabolic impact of alternative respiratory chain enzymes - p. 105 13. Chapter 5 Aging, mitochondrial dysfunctions, and vitamin E - p. 131 14. Chapter 6 The role of B vitamins in protecting mitochondrial function - p. 167 15. Chapter 7 Analysis of the mitochondrial status of murine neuronal N2a cells treated with resveratrol and synthetic isomeric resveratrol analogs: aza-stilbenes - p. 195 16. Chapter 8 Dietary eicosapentaenoic acid and docosahexaenoic acid for mitochondrial biogenesis and dynamics - p. 213 17. Chapter 9 Vitamin C and mitochondrial function in health and exercise - p. 225 18. Chapter 10 Roles of dietary fiber and gut microbial metabolites short-chain fatty acids in regulating mitochondrial function in central nervous system - p. 243 19. Chapter 11 Mitochondria-targeted antioxidants: coenzyme Q10, mito-Q and beyond - p. 255 20. Chapter 12 Flavonoids, mitochondrial enzymes and heart protection - p. 303 21. Chapter 13 Tea polyphenols stimulate mt bioenergetics in cardiometabolic diseases - p. 333 22. Chapter 14 A review of quercetin delivery through nanovectors: cellular and mitochondrial effects on noncommunicable diseases - p. 363 23. Chapter 15 Creatine monohydrate for mitochondrial nutrition - p. 383 24. Chapter 16 Arginine and neuroprotection: a focus on stroke - p. 417 25. Chapter 17 Nutraceuticals for targeting NAD+ to restore mitochondrial function - p. 433 26. Chapter 18 Curcumin for protecting mitochondria and downregulating inflammation - p. 461 27. Chapter 19 Dihydrogen as an innovative nutraceutical for mitochondrial viability - p. 501 28. Chapter 20 Fucoxantin and mitochondrial uncoupling protein 1 in obesity - p. 513 29. Chapter 21 Rice bran extract for the prevention of mitochondrial dysfunction - p. 521 30. Chapter 22 Silymarin as a vitagene modulator: effects on mitochondria integrity in stress conditions - p. 535 31. Chapter 23 Buckwheat trypsin inhibitors: novel nutraceuticals for mitochondrial homeostasis - p. 561 32. Chapter 24 Diet restriction-induced mitochondrial signaling and healthy aging - p. 587 33. Chapter 25 Rejuvenation of mitochondrial function by time-controlled fasting - p. 633 34. Chapter 26 Dietary modulation and mitochondrial DNA damage - p. 651 35. Index - p. 667 36. Index - Continued - p. 680
