Neurobiology of Abnormal Emotion and Motivated Behaviors: Integrating Animal and Human Research pulls together world-renowned leaders from both animal and human research, providing a conceptual framework on how neuroscience can inform our understanding of emotion and motivation, while also outlining methodological commonalities between animal and human neuroscience research, with an emphasis on experimental design, physiological recording techniques and outcome measures. Typically, researchers investigating the neurobiology of emotions focus on either animal models or humans. This book brings the two disciplines together to share information and collaborate on future experimental techniques, physiological measures and clinical outcomes.
1. Introduction Emotion and Motivated Behaviors: Integrating Animal and Human Neurobiology Research - p. xvii 2. Section I: Emotion-Related Impulsivity Across Disorders and Species - p. xx 3. 1. Using Preclinical Models to Understand the Neural Basis of Negative Urgency - p. 2 4. 2. Emotion-Related Impulsivity and the Mood Disorders - p. 22 5. Section II: Impulsivity and Stress in Eating Disorders - p. 34 6. 3. Impulsivity, Stress Reactivity, and Eating Disorders - p. 42 7. 4. The Genetic Diathesis of Eating Disorders: Critical Roles for Puberty and Ovarian Hormones - p. 60 8. 5. Animal Models of Behavioral and Neuroendocrine Components of Eating Disorders - p. 74 9. 6. A Framework for Elucidating Causes and Consequences of Malnutrition in Anorexia Nervosa - p. 92 10. Section III: Interaction of Stress and Drug-Seeking - p. 111 11. 7. Stress System Sensitivity and Emotion Regulation in Early Abstinence from Substance Use Disorders—Targets for Medications Development - p. 120 12. 8. Effects of Stress and Chronic Alcohol Exposure on Emotional Behavior and Alcohol Consumption - p. 142 13. 9. A Genetic Mouse Model for Comorbid Alcohol Use Disorder and Posttraumatic Stress Disorder - p. 164 14. Section IV: Learning to Inhibit the Fear Response - p. 176 15. 10. Neural Circuits for Fear Relapse - p. 182 16. 11. Brain Mechanisms for Learning and Using Safety Signals - p. 204 17. 12. Animal Models to Investigate Social Support Induced Anxiety Reductions - p. 224 18. Section V: Abnormal Emotional Reactivity Versus Regulation Across Disorders - p. 235 19. 13. Neurophysiological Assessment of Anhedonia in Depression and Schizophrenia - p. 242 20. 14. The Role of Negative Emotion Abnormalities in Anhedonic Symptoms of Schizophrenia - p. 258 21. 15. Motivational Impairments in Psychotic and Depressive Pathology: Psychological and Neural Mechanisms - p. 278 22. Perspectives and Future Directions for Integrating Animal and Human Neurobiology Research on Abnormal Emotion and Motivated Behaviors - p. 305 23. Index - p. 311
Neurobiology of Abnormal Emotion and Motivated Behaviors: Integrating Animal and Human Research pulls together world-renowned leaders from both animal and human research, providing a conceptual framework on how neuroscience can inform our understanding of emotion and motivation, while also outlining methodological commonalities between animal and human neuroscience research, with an emphasis on experimental design, physiological recording techniques and outcome measures. Typically, researchers investigating the neurobiology of emotions focus on either animal models or humans. This book brings the two disciplines together to share information and collaborate on future experimental techniques, physiological measures and clinical outcomes.
1. Introduction Emotion and Motivated Behaviors: Integrating Animal and Human Neurobiology Research - p. xvii 2. Section I: Emotion-Related Impulsivity Across Disorders and Species - p. xx 3. 1. Using Preclinical Models to Understand the Neural Basis of Negative Urgency - p. 2 4. 2. Emotion-Related Impulsivity and the Mood Disorders - p. 22 5. Section II: Impulsivity and Stress in Eating Disorders - p. 34 6. 3. Impulsivity, Stress Reactivity, and Eating Disorders - p. 42 7. 4. The Genetic Diathesis of Eating Disorders: Critical Roles for Puberty and Ovarian Hormones - p. 60 8. 5. Animal Models of Behavioral and Neuroendocrine Components of Eating Disorders - p. 74 9. 6. A Framework for Elucidating Causes and Consequences of Malnutrition in Anorexia Nervosa - p. 92 10. Section III: Interaction of Stress and Drug-Seeking - p. 111 11. 7. Stress System Sensitivity and Emotion Regulation in Early Abstinence from Substance Use Disorders—Targets for Medications Development - p. 120 12. 8. Effects of Stress and Chronic Alcohol Exposure on Emotional Behavior and Alcohol Consumption - p. 142 13. 9. A Genetic Mouse Model for Comorbid Alcohol Use Disorder and Posttraumatic Stress Disorder - p. 164 14. Section IV: Learning to Inhibit the Fear Response - p. 176 15. 10. Neural Circuits for Fear Relapse - p. 182 16. 11. Brain Mechanisms for Learning and Using Safety Signals - p. 204 17. 12. Animal Models to Investigate Social Support Induced Anxiety Reductions - p. 224 18. Section V: Abnormal Emotional Reactivity Versus Regulation Across Disorders - p. 235 19. 13. Neurophysiological Assessment of Anhedonia in Depression and Schizophrenia - p. 242 20. 14. The Role of Negative Emotion Abnormalities in Anhedonic Symptoms of Schizophrenia - p. 258 21. 15. Motivational Impairments in Psychotic and Depressive Pathology: Psychological and Neural Mechanisms - p. 278 22. Perspectives and Future Directions for Integrating Animal and Human Neurobiology Research on Abnormal Emotion and Motivated Behaviors - p. 305 23. Index - p. 311
