Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition provides basic scientists a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases. Topics include developmental, autoimmune, central, and peripheral neurodegeneration, infectious diseases, and diseases of higher function.
Organized by individual disorder, each chapter includes coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. This volume reflects progress in the field since publication of the first edition, with fully updated chapters, and new chapters on isolation, aging, global diseases, vascular diseases, and toxic/metabolic disease. New disorder coverage includes fibromyalgia, chronic fatigue, Restless Legs Syndrome, myasthenia gravis, and more.
1. Section I: Introduction - p. xxviii 2. Introduction - p. 3 3. Developmental disabilities and metabolic disorders - p. 7 4. Attention-deficit/hyperactivity disorder - p. 29 5. Down syndrome: a model for chromosome abnormalities - p. 45 6. Autism spectrum disorder - p. 69 7. Rett syndrome: from the involved gene(s) to treatment - p. 89 8. Fragile X-associated disorders - p. 115 9. Section II: Diseases of the peripheral nervous system - p. 125 10. Introduction - p. 129 11. Myasthenia gravis - p. 131 12. Muscular dystrophy - p. 147 13. Peripheral neuropathies - p. 165 14. Diabetes and cognitive dysfunction - p. 185 15. Tumors of the nervous system - p. 203 16. Section III: Neurodegenerative diseases - p. 228 17. Introduction to neurodegenerative disease section - p. 231 18. Amyotrophic lateral sclerosis - p. 233 19. Parkinson disease and other synucleinopathies - p. 253 20. Huntington disease - p. 275 21. Repeat expansion disorders - p. 293 22. Alzheimer diseases - p. 313 23. Frontotemporal lobar degeneration - p. 337 24. Prion diseases - p. 361 25. Toxic/metabolic diseases of the nervous system - p. 379 26. The role of inflammation in neurodegenerative diseases - p. 403 27. Section IV: Acute insults to the central nervous system - p. 421 28. Introduction: acute insults to the central nervous system - p. 421 29. Spinal cord injury - p. 427 30. Traumatic brain injury - p. 443 31. Cerebrovascular disease—stroke - p. 457 32. Section V: Infectious and immune-mediated diseases affecting the nervous system - p. 476 33. Introduction - p. 479 34. Infections and nervous system dysfunctions - p. 481 35. Pathobiology of CNS human immunodeficiency virus infection - p. 501 36. Autoimmune and paraneoplastic neurological disorders - p. 525 37. Fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome - p. 559 38. Multiple sclerosis and neuromyelitis optica spectrum disorders - p. 575 39. Section VI: Diseases of higher function - p. 608 40. Introduction - p. 611 41. Disorders of higher cortical function - p. 613 42. Neurobioloy of sleep and circadian disorders - p. 635 43. Restless Legs Syndrome - p. 659 44. Pain: from neurobiology to disease - p. 671 45. Migraine - p. 691 46. Dystonia - p. 713 47. Epilepsy - p. 753 48. Stress - p. 781 49. Addictions - p. 793 50. Fear-related anxiety disorders and posttraumatic stress disorder - p. 811 51. Obsessive–compulsive disorder - p. 825 52. The neurobiology of schizophrenia - p. 843 53. Depression and suicide - p. 861 54. Inflammation as a mediator of stress-related psychiatric disorders - p. 885 55. Role of the gut microbiome in the pathophysiology of brain disorders - p. 913 56. Section VII: Interface between biology and society in diseases of the nervous system - p. 928 57. Introduction - p. 931 58. Sex differences in neurological and psychiatric diseases - p. 933 59. Integrative medicine in neurology - p. 953 60. The impact of isolation on brain health - p. 963 61. The neurobiology of aging - p. 977 62. Palliative care in neurological disease - p. 995 63. Racial/ethnic health disparities - p. 1009 64. Advances in ethics for the neuroscience agenda - p. 1025 65. Burden of neurological disease - p. 1047 66. Index - p. 1065
Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition provides basic scientists a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases. Topics include developmental, autoimmune, central, and peripheral neurodegeneration, infectious diseases, and diseases of higher function.
Organized by individual disorder, each chapter includes coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. This volume reflects progress in the field since publication of the first edition, with fully updated chapters, and new chapters on isolation, aging, global diseases, vascular diseases, and toxic/metabolic disease. New disorder coverage includes fibromyalgia, chronic fatigue, Restless Legs Syndrome, myasthenia gravis, and more.
1. Section I: Introduction - p. xxviii 2. Introduction - p. 3 3. Developmental disabilities and metabolic disorders - p. 7 4. Attention-deficit/hyperactivity disorder - p. 29 5. Down syndrome: a model for chromosome abnormalities - p. 45 6. Autism spectrum disorder - p. 69 7. Rett syndrome: from the involved gene(s) to treatment - p. 89 8. Fragile X-associated disorders - p. 115 9. Section II: Diseases of the peripheral nervous system - p. 125 10. Introduction - p. 129 11. Myasthenia gravis - p. 131 12. Muscular dystrophy - p. 147 13. Peripheral neuropathies - p. 165 14. Diabetes and cognitive dysfunction - p. 185 15. Tumors of the nervous system - p. 203 16. Section III: Neurodegenerative diseases - p. 228 17. Introduction to neurodegenerative disease section - p. 231 18. Amyotrophic lateral sclerosis - p. 233 19. Parkinson disease and other synucleinopathies - p. 253 20. Huntington disease - p. 275 21. Repeat expansion disorders - p. 293 22. Alzheimer diseases - p. 313 23. Frontotemporal lobar degeneration - p. 337 24. Prion diseases - p. 361 25. Toxic/metabolic diseases of the nervous system - p. 379 26. The role of inflammation in neurodegenerative diseases - p. 403 27. Section IV: Acute insults to the central nervous system - p. 421 28. Introduction: acute insults to the central nervous system - p. 421 29. Spinal cord injury - p. 427 30. Traumatic brain injury - p. 443 31. Cerebrovascular disease—stroke - p. 457 32. Section V: Infectious and immune-mediated diseases affecting the nervous system - p. 476 33. Introduction - p. 479 34. Infections and nervous system dysfunctions - p. 481 35. Pathobiology of CNS human immunodeficiency virus infection - p. 501 36. Autoimmune and paraneoplastic neurological disorders - p. 525 37. Fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome - p. 559 38. Multiple sclerosis and neuromyelitis optica spectrum disorders - p. 575 39. Section VI: Diseases of higher function - p. 608 40. Introduction - p. 611 41. Disorders of higher cortical function - p. 613 42. Neurobioloy of sleep and circadian disorders - p. 635 43. Restless Legs Syndrome - p. 659 44. Pain: from neurobiology to disease - p. 671 45. Migraine - p. 691 46. Dystonia - p. 713 47. Epilepsy - p. 753 48. Stress - p. 781 49. Addictions - p. 793 50. Fear-related anxiety disorders and posttraumatic stress disorder - p. 811 51. Obsessive–compulsive disorder - p. 825 52. The neurobiology of schizophrenia - p. 843 53. Depression and suicide - p. 861 54. Inflammation as a mediator of stress-related psychiatric disorders - p. 885 55. Role of the gut microbiome in the pathophysiology of brain disorders - p. 913 56. Section VII: Interface between biology and society in diseases of the nervous system - p. 928 57. Introduction - p. 931 58. Sex differences in neurological and psychiatric diseases - p. 933 59. Integrative medicine in neurology - p. 953 60. The impact of isolation on brain health - p. 963 61. The neurobiology of aging - p. 977 62. Palliative care in neurological disease - p. 995 63. Racial/ethnic health disparities - p. 1009 64. Advances in ethics for the neuroscience agenda - p. 1025 65. Burden of neurological disease - p. 1047 66. Index - p. 1065
