Unparalleled in scope and content, Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas provides the most relevant and up-to-date clinical, etiologic, molecular, and therapeutic management information for surgical pathologists in training and in practice. The fully revised 4th Edition of this award-winning title offers a wealth of information in this fast-changing field, including recent advances in molecular biology and immunohistochemistry, in a clearly written, well-structured manner that is easy to read and navigate. This one-stop reference for the entire gastrointestinal system enables you to improve turnaround time when diagnosing a specimen and to clearly report on the prognosis and therapeutic management options to surgical and medical colleagues.
Covers the latest developments in molecular technologies and immunohistochemical markers to provide useful diagnostic and prognostic information and inform therapeutic decisions.
Provides all the necessary tools to make a comprehensive diagnostic workup, including data from ancillary techniques and molecular findings whenever appropriate.
Incorporates more than 3000 high-quality color illustrations to help you recognize and diagnose any tissue sample under the microscope.
Reviews next-generation sequencing (NGS) to help identify targetable mutations in gastrointestinal tract tumors and provide more accurate classification and precision therapies.
Features extensive tables, graphs, and flowcharts to help you effectively grasp complex topics and streamline your decision-making.
Helps you avoid diagnostic errors with practical advice on pitfalls in differential diagnosis.
Incorporates the latest WHO guidelines throughout.
Winner of the 2015 BMA Medical Book Awards First Prize Award in Pathology.
1. Introduction - p. 53 2. Viral Infections of the GI Tract - p. 53 3. Bacterial Infections of the GI Tract - p. 61 4. Fungal Infections of the GI Tract - p. 82 5. Parasitic Infections of the GI Tract - p. 86 6. Chapter 5. Manifestations of Immunodeficiency in the Gastrointestinal Tract - p. 99 7. Chapter 6. Autoimmune Disorders of the Gastrointestinal Tract - p. 123 8. Chapter 7. Systemic Illnesses Involving the Gastrointestinal Tract - p. 135 9. Chapter 8. Neuromuscular Disorders of the Gastrointestinal Tract - p. 158 10. Introduction - p. 158 11. Esophagus - p. 161 12. Stomach - p. 165 13. Small and Large Intestine - p. 167 14. Differential Diagnosis and Workup of Patients with Intestinal Dysmotility - p. 193 15. Conclusion and Future Outlook - p. 199 16. Chapter 9. Congenital and Developmental Disorders of the Gastrointestinal Tract - p. 200 17. Chapter 10. Enteropathies Associated with Chronic Diarrhea and Malabsorption in Childhood - p. 224 18. 11. Vascular Disorders of the Gastrointestinal Tract - p. 241 19. Chapter 12. Drug-Induced Disorders of the Gastrointestinal Tract - p. 294 20. Section II. Inflammatory Disorders of the Gastrointestinal Tract - p. 316.e10 21. Chapter 13. Algorithmic Approach to Diagnosis of Inflammatory Disorders of the Gastrointestinal Tract - p. 318 22. Chapter 14. Inflammatory Disorders of the Esophagus - p. 339 23. Introduction - p. 339 24. Gastroesophageal Reflux Disease - p. 339 25. Infectious Esophagitis - p. 346 26. Pill-, Drug-, and Toxin-Related Esophagitis - p. 350 27. Esophagitis Dissecans Superficialis - p. 352 28. Primary Eosinophilic Esophagitis (EOE) - p. 353 29. Lymphocytic Esophagitis - p. 358 30. Mechanical Causes of Esophagitis - p. 358 31. Congenital and Acquired Deformations - p. 361 32. Esophageal Involvement in Systemic Disease - p. 362 33. Esophageal Epidermoid Metaplasia (Esophageal Leukoplakia) - p. 367 34. Barrett’s Esophagus - p. 368 35. Neoplasia in Barrett’s Esophagus - p. 378 36. Chapter 15. Inflammatory Disorders of the Stomach - p. 396 37. Historical Perspective - p. 396 38. General Pathological Features of Gastritis - p. 397 39. Updated Sydney System - p. 405 40. Olga and Olgim Systems - p. 408 41. Acute And Subacute Mucosal Injury (Acute Gastritis) - p. 409 42. Chronic Gastritis - p. 418 43. Specific Patterns of Gastritis - p. 431 44. Vascular Gastropathies - p. 436 45. Gastric Mucosal Depositions - p. 438 46. Gastric Cardia And The Gastroesophageal Junction - p. 439 47. The Stomach In The Young And Elderly - p. 445 48. Gastric Epithelial Dysplasia - p. 445 49. Chapter 16. Inflammatory Disorders of the Small Intestine - p. 454 50. Disorders of Malabsorption - p. 454 51. Eosinophilic Gastroenteritis - p. 470 52. Nutritional Deficiencies - p. 472 53. Peptic Duodenitis and Duodenal Ulcer - p. 474 54. Drug Injury of The Small Bowel - p. 475 55. Inflammatory Bowel Disease - p. 481 56. Ischemic Disorders of The Small Intestine - p. 490 57. Cryptogenic Multifocal Ulcerating Stenosing Enteritis - p. 492 58. Graft-Versus-Host Disease - p. 493 59. Intestinal Lymphangiectasia - p. 493 60. Waldenström’s Macroglobulinemia - p. 494 61. Pneumatosis Cystoides Intestinalis - p. 495 62. Pseudomelanosis Duodeni - p. 495 63. Chapter 17. Inflammatory Disorders of the Large Intestine - p. 496 64. Approach To Evaluating Colitis - p. 496 65. Ulcerative Colitis - p. 498 66. Crohn’s Colitis - p. 512 67. Chronic Inflammatory Bowel Disease, Type Unknown (“Indeterminate” Colitis) - p. 519 68. Dysplasia In Ulcerative Colitis And Crohn’s Disease - p. 522 69. Non-Ibd Colitis - p. 535 70. Mastocytic Disorders - p. 561 71. Drug-Induced Colitis - p. 572 72. Chemotherapy-Associated Colonic Injury - p. 579 73. Effects Of Bowel Preparation Agents - p. 580 74. Effects of Mucosal Prolapse In The Colon - p. 581 75. Behçet’s Syndrome - p. 585 76. Chapter 18. Inflammatory Disorders of the Appendix - p. 587 77. Section III. Polyps of the Gastrointestinal Tract - p. 613.e5 78. Chapter 19. Polyps of the Esophagus - p. 616 79. Chapter 20. Polyps of the Stomach - p. 628 80. Introduction - p. 628 81. Hyperplastic Polyps - p. 628 82. Ménétrier’s Disease - p. 636 83. Hamartomatous Polyps - p. 638 84. Embryonic Rests and Heterotopia - p. 646 85. Neoplastic Epithelial Polyps - p. 648 86. Nonepithelial Polyps - p. 658 87. Lymphoid Polyps - p. 661 88. Miscellaneous Rare Polyps and Polyp-Like Lesions - p. 661 89. Chapter 21. Polyps of the Small Intestine - p. 665 90. Chapter 22. Polyps of the Large Intestine - p. 693 91. Introduction - p. 693 92. Endoscopic Classification of Polyps - p. 694 93. Adenomatous Polyps - p. 694 94. Serrated Polyps - p. 703 95. Malignant Polyps - p. 714 96. Inflammatory Polyps - p. 718 97. Polyps Associated With Mucosal Prolapse - p. 719 98. Hamartomatous Polyps - p. 724 99. Visible Dysplastic Lesions in Inflammatory Bowel Disease - p. 733 100. Mesenchymal Polyps - p. 734 101. Miscellaneous Polypoid Lesions - p. 744 102. Section IV. Epithelial Neoplasms of the Gastrointestinal Tract - p. 749.e19 103. Chapter 23. Molecular Diagnostics of Tubal Gut Neoplasms - p. 752 104. Chapter 24. Epithelial Neoplasms of the Esophagus - p. 772 105. Chapter 25. Epithelial Neoplasms of the Stomach - p. 811 106. Introduction - p. 811 107. Pathogenesis - p. 812 108. Histological Precursors Of Gastric Carcinoma - p. 813 109. Early Gastric Carcinoma - p. 814 110. Advanced Gastric Carcinoma - p. 816 111. Major Histological Classifications Of Gastric Carcinoma - p. 818 112. Other Types Of Gastric Cancer - p. 826 113. Gastric Carcinoma In Special Clinical Circumstances - p. 828 114. Molecular Pathology Of Gastric Cancer - p. 829 115. Spread And Metastases - p. 834 116. Prognosis - p. 834 117. Management And Treatment - p. 834 118. Hereditary Gastric Cancer Syndromes - p. 836 119. Chapter 26. Epithelial Neoplasms of the Small Intestine - p. 845 120. Chapter 27. Epithelial Neoplasms of the Large Intestine - p. 860 121. Introduction - p. 861 122. Clinical Features - p. 861 123. Incidence - p. 861 124. Epidemiology - p. 863 125. Pathogenesis - p. 865 126. Gross Features and Specimen Handling - p. 870 127. Pathological Features - p. 873 128. Classification of Histological Subtypes - p. 874 129. Special Studies - p. 888 130. Differential Diagnosis - p. 890 131. Natural History - p. 891 132. Treatment - p. 891 133. Prognostic Factors - p. 895 134. Hereditary Colorectal Carcinoma - p. 909 135. Colorectal Cancer in Serrated Polyposis - p. 918 136. Colitis-Associated Neoplasia - p. 919 137. Chapter 28. Epithelial Neoplasms of the Appendix - p. 922 138. Chapter 29. Neuroendocrine Tumors of the Gastrointestinal and Pancreatobiliary Tracts - p. 951 139. Section V. Nonepithelial Neoplasms of the Gastrointestinal Tract - p. 970.e6 140. Chapter 30. Mesenchymal Tumors of the Gastrointestinal Tract - p. 972 141. Chapter 31. Hematolymphoid Tumors of the Gastrointestinal Tract, Hepatobiliary Tract, and Pancreas - p. 997 142. Introduction - p. 997 143. Gastric Marginal-Zone Lymphoma of Mucosa-Associated Lymphoid Tissue (Malt Lymphoma) - p. 998 144. Intestinal Marginal-Zone Lymphoma of Mucosa-Associated Lymphoid Tissue (Malt Lymphoma) - p. 1003 145. Immunoproliferative Small Intestinal Disease - p. 1004 146. Gastric Diffuse Large B-Cell Lymphoma - p. 1006 147. Intestinal Diffuse Large B-Cell Lymphoma - p. 1007 148. Mantle Cell Lymphoma - p. 1008 149. Duodenal-Type Follicular Lymphoma - p. 1010 150. Burkitt’s Lymphoma - p. 1012 151. Enteropathy-Associated T-Cell Lymphoma - p. 1014 152. Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma - p. 1016 153. Complicated Celiac Disease: Refractory Sprue and Ulcerative Jejunitis - p. 1018 154. Extranodal NK/T-Cell Lymphoma, Nasal Type - p. 1019 155. Other GI T-Cell Lymphomas - p. 1019 156. Indolent T-Cell Lymphoproliferative Disorder of the GI Tract - p. 1020 157. Appendiceal Lymphoma - p. 1021 158. Hodgkin Lymphoma of the GI Tract - p. 1022 159. GI Lymphoproliferative Disorders in Abnormal Immune States - p. 1023 160. Hepatic Lymphoma - p. 1026 161. Lymphomas of the Gallbladder - p. 1030 162. Lymphomas of the Extrahepatic Bile Ducts - p. 1030 163. Pancreatic Lymphoma - p. 1031 164. Proliferations of Histiocytes and Dendritic Cells in the GI Tract and Liver - p. 1032 165. Section VI. Anal Pathology - p. 1038.e12 166. Chapter 32. Inflammatory and Neoplastic Disorders of the Anal Canal - p. 1040 167. Part 2. Gallbladder, Extrahepatic Biliary Tract, and Pancreas - p. 1080.e9 168. Chapter 33. Algorithmic Approach to Diagnosis of Pancreatic Disorders - p. 1082 169. Chapter 34. Gallbladder, Extrahepatic Biliary Tract, and Pancreas Tissue Processing Techniques and Normal Histology - p. 1090 170. Chapter 35. Molecular Genetics of Pancreatobiliary Neoplasms - p. 1106 171. Chapter 36. Diagnostic Cytology of the Biliary Tract and Pancreas - p. 1119 172. Chapter 37. Developmental Disorders of the Gallbladder, Extrahepatic Biliary Tract, and Pancreas - p. 1154 173. Chapter 38. Infectious and Inflammatory Disorders of the Gallbladder and Extrahepatic Biliary Tract - p. 1169 174. Chapter 39. Benign and Malignant Tumors of the Gallbladder and Extrahepatic Biliary Tract - p. 1197 175. Introduction - p. 1197 176. Sampling of Gallbladder Specimens - p. 1197 177. Gallbladder - p. 1198 178. Extrahepatic Bile Ducts - p. 1226 179. Nonepithelial Tumors of the Gallbladder and Extrahepatic Bile Ducts - p. 1234 180. Secondary Tumors of the Gallbladder and Extrahepatic Bile Ducts - p. 1234 181. Chapter 40. Inflammatory and Other Nonneoplastic Disorders of the Pancreas - p. 1236 182. Chapter 41. Tumors of the Pancreas - p. 1265 183. Introduction And Classification - p. 1265 184. Ductal Adenocarcinoma And Variants - p. 1267 185. Pancreatic Intraepithelial Neoplasia - p. 1277 186. Intraductal Neoplasms - p. 1278 187. Cystic Neoplasms - p. 1284 188. Differential Diagnosis Of Cystic And Intraductal Lesions - p. 1290 189. Acinar Cell Carcinoma, Pancreatoblastoma, And Related Entities - p. 1291 190. Pancreatic Neuroendocrine Neoplasms - p. 1295 191. Solid Pseudopapillary Neoplasms - p. 1296 192. Differential Diagnosis Of Solid Cellular Neoplasms - p. 1297 193. Mesenchymal And Lymphoid Neoplasms - p. 1298 194. Tumor-Like Lesions - p. 1300 195. Secondary Tumors - p. 1301 196. Acknowledgment - p. 1301 197. Chapter 42. Tumors of Major and Minor Ampullae - p. 1302 198. Part 3. Liver - p. 1321.e6 199. Chapter 43. Algorithmic Approach to Diagnosis of Medical Liver Disorders - p. 1324 200. Chapter 44. Liver Tissue Processing and Normal Histology - p. 1352 201. Chapter 45. Molecular Pathogenesis and Diagnostics of Hepatocellular Tumors - p. 1369 202. Chapter 46. Diagnostic Cytology of the Liver - p. 1384 203. Chapter 47. Acute and Chronic Infectious Hepatitis - p. 1416 204. Introduction - p. 1416 205. Viral Hepatitis - p. 1416 206. Other Viral Infections Of The Liver - p. 1435 207. Bacterial Infections Of The Liver - p. 1440 208. Fungal Infections of the Liver - p. 1449 209. Parasitic Infections of the Liver - p. 1451 210. Chapter 48. Autoimmune and Chronic Cholestatic Disorders of the Liver - p. 1458 211. Introduction - p. 1458 212. Autoimmune Hepatitis - p. 1458 213. Primary Biliary Cholangitis - p. 1469 214. Primary Sclerosing Cholangitis - p. 1476 215. Overlap Syndromes - p. 1482 216. Immunoglobulin G4–Related Sclerosing Cholangitis - p. 1484 217. Immunoglobulin G4-Related Autoimmune Hepatitis - p. 1491 218. Secondary Sclerosing Cholangitis - p. 1492 219. Ischemic Cholangitis - p. 1492 220. Miscellaneous Ductopenic Syndromes - p. 1493 221. Obstructive Cholangitis - p. 1493 222. Post–Covid-19 Cholangiopathy - p. 1494 223. Chapter 49. Toxin- and Drug-Induced Disorders of the Liver - p. 1497 224. Introduction - p. 1497 225. Epidemiology - p. 1499 226. Clinical Assessment and Prediction of Hepatotoxicity - p. 1500 227. Prevention of Drug Hepatotoxicity - p. 1501 228. Treatment and Prognosis - p. 1502 229. Pathological Patterns of Toxic Liver Injury - p. 1503 230. Examples of Common Offending Drugs - p. 1527 231. Acknowledgments - p. 1543 232. Chapter 50. Fatty Liver Disease - p. 1544 233. Introduction - p. 1544 234. Alcohol-Induced Liver Disease - p. 1545 235. Nonalcoholic Fatty Liver Disease - p. 1553 236. Fatty Liver Disease in Various Patient Groups - p. 1567 237. Differentiating Alcoholic from Nonalcoholic Fatty Liver Disease - p. 1570 238. Grading and Staging of Fatty Liver Disease - p. 1571 239. Other Forms of Fatty Liver Disease - p. 1574 240. Chapter 51. Cirrhosis - p. 1577 241. Chapter 52. Vascular Disorders of the Liver - p. 1595 242. Chapter 53. Pathology of Liver and Hematopoietic Stem Cell Transplantation - p. 1627 243. Introduction - p. 1627 244. Donor Evaluation - p. 1628 245. Sources of Graft Dysfunction - p. 1632 246. Complications of Transplantation - p. 1638 247. Late Liver Allograft Dysfunction - p. 1667 248. Other Transplantation Effects - p. 1686 249. Acknowledgment - p. 1691 250. Chapter 54. Liver Pathology in Pregnancy - p. 1692 251. Chapter 55. Inherited Metabolic and Developmental Disorders of the Pediatric and Adult Liver - p. 1706 252. Introduction - p. 1707 253. Pediatric Liver Biopsies - p. 1707 254. Approach to the Diagnosis of Pediatric Liver Disorders in Liver Biopsies - p. 1711 255. Liver Diseases of Infancy - p. 1720 256. Paucity of Intrahepatic Bile Ducts - p. 1732 257. Hereditary Disorders of Bilirubin Metabolism - p. 1736 258. Hereditary Disorders of Bile Acid Metabolism and Bile Formation - p. 1737 259. Disorders of Carbohydrate Metabolism - p. 1745 260. Congenital Disorders of Glycosylation - p. 1749 261. Disorders of Amino Acid Metabolism - p. 1749 262. Disorders of Lipid Metabolism - p. 1750 263. Peroxisomal Disorders - p. 1754 264. Urea Cycle Disorders - p. 1757 265. Inherited and Metabolic Diseases of Adolescents And Adults - p. 1758 266. Abnormal Development of Liver Anatomy - p. 1766 267. Abnormal Development of the Biliary Tract - p. 1769 268. Conclusion - p. 1773 269. Chapter 56. Benign and Malignant Tumors of the Liver - p. 1774 270. Index - p. 1811
Unparalleled in scope and content, Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas provides the most relevant and up-to-date clinical, etiologic, molecular, and therapeutic management information for surgical pathologists in training and in practice. The fully revised 4th Edition of this award-winning title offers a wealth of information in this fast-changing field, including recent advances in molecular biology and immunohistochemistry, in a clearly written, well-structured manner that is easy to read and navigate. This one-stop reference for the entire gastrointestinal system enables you to improve turnaround time when diagnosing a specimen and to clearly report on the prognosis and therapeutic management options to surgical and medical colleagues.
Covers the latest developments in molecular technologies and immunohistochemical markers to provide useful diagnostic and prognostic information and inform therapeutic decisions.
Provides all the necessary tools to make a comprehensive diagnostic workup, including data from ancillary techniques and molecular findings whenever appropriate.
Incorporates more than 3000 high-quality color illustrations to help you recognize and diagnose any tissue sample under the microscope.
Reviews next-generation sequencing (NGS) to help identify targetable mutations in gastrointestinal tract tumors and provide more accurate classification and precision therapies.
Features extensive tables, graphs, and flowcharts to help you effectively grasp complex topics and streamline your decision-making.
Helps you avoid diagnostic errors with practical advice on pitfalls in differential diagnosis.
Incorporates the latest WHO guidelines throughout.
Winner of the 2015 BMA Medical Book Awards First Prize Award in Pathology.
1. Introduction - p. 53 2. Viral Infections of the GI Tract - p. 53 3. Bacterial Infections of the GI Tract - p. 61 4. Fungal Infections of the GI Tract - p. 82 5. Parasitic Infections of the GI Tract - p. 86 6. Chapter 5. Manifestations of Immunodeficiency in the Gastrointestinal Tract - p. 99 7. Chapter 6. Autoimmune Disorders of the Gastrointestinal Tract - p. 123 8. Chapter 7. Systemic Illnesses Involving the Gastrointestinal Tract - p. 135 9. Chapter 8. Neuromuscular Disorders of the Gastrointestinal Tract - p. 158 10. Introduction - p. 158 11. Esophagus - p. 161 12. Stomach - p. 165 13. Small and Large Intestine - p. 167 14. Differential Diagnosis and Workup of Patients with Intestinal Dysmotility - p. 193 15. Conclusion and Future Outlook - p. 199 16. Chapter 9. Congenital and Developmental Disorders of the Gastrointestinal Tract - p. 200 17. Chapter 10. Enteropathies Associated with Chronic Diarrhea and Malabsorption in Childhood - p. 224 18. 11. Vascular Disorders of the Gastrointestinal Tract - p. 241 19. Chapter 12. Drug-Induced Disorders of the Gastrointestinal Tract - p. 294 20. Section II. Inflammatory Disorders of the Gastrointestinal Tract - p. 316.e10 21. Chapter 13. Algorithmic Approach to Diagnosis of Inflammatory Disorders of the Gastrointestinal Tract - p. 318 22. Chapter 14. Inflammatory Disorders of the Esophagus - p. 339 23. Introduction - p. 339 24. Gastroesophageal Reflux Disease - p. 339 25. Infectious Esophagitis - p. 346 26. Pill-, Drug-, and Toxin-Related Esophagitis - p. 350 27. Esophagitis Dissecans Superficialis - p. 352 28. Primary Eosinophilic Esophagitis (EOE) - p. 353 29. Lymphocytic Esophagitis - p. 358 30. Mechanical Causes of Esophagitis - p. 358 31. Congenital and Acquired Deformations - p. 361 32. Esophageal Involvement in Systemic Disease - p. 362 33. Esophageal Epidermoid Metaplasia (Esophageal Leukoplakia) - p. 367 34. Barrett’s Esophagus - p. 368 35. Neoplasia in Barrett’s Esophagus - p. 378 36. Chapter 15. Inflammatory Disorders of the Stomach - p. 396 37. Historical Perspective - p. 396 38. General Pathological Features of Gastritis - p. 397 39. Updated Sydney System - p. 405 40. Olga and Olgim Systems - p. 408 41. Acute And Subacute Mucosal Injury (Acute Gastritis) - p. 409 42. Chronic Gastritis - p. 418 43. Specific Patterns of Gastritis - p. 431 44. Vascular Gastropathies - p. 436 45. Gastric Mucosal Depositions - p. 438 46. Gastric Cardia And The Gastroesophageal Junction - p. 439 47. The Stomach In The Young And Elderly - p. 445 48. Gastric Epithelial Dysplasia - p. 445 49. Chapter 16. Inflammatory Disorders of the Small Intestine - p. 454 50. Disorders of Malabsorption - p. 454 51. Eosinophilic Gastroenteritis - p. 470 52. Nutritional Deficiencies - p. 472 53. Peptic Duodenitis and Duodenal Ulcer - p. 474 54. Drug Injury of The Small Bowel - p. 475 55. Inflammatory Bowel Disease - p. 481 56. Ischemic Disorders of The Small Intestine - p. 490 57. Cryptogenic Multifocal Ulcerating Stenosing Enteritis - p. 492 58. Graft-Versus-Host Disease - p. 493 59. Intestinal Lymphangiectasia - p. 493 60. Waldenström’s Macroglobulinemia - p. 494 61. Pneumatosis Cystoides Intestinalis - p. 495 62. Pseudomelanosis Duodeni - p. 495 63. Chapter 17. Inflammatory Disorders of the Large Intestine - p. 496 64. Approach To Evaluating Colitis - p. 496 65. Ulcerative Colitis - p. 498 66. Crohn’s Colitis - p. 512 67. Chronic Inflammatory Bowel Disease, Type Unknown (“Indeterminate” Colitis) - p. 519 68. Dysplasia In Ulcerative Colitis And Crohn’s Disease - p. 522 69. Non-Ibd Colitis - p. 535 70. Mastocytic Disorders - p. 561 71. Drug-Induced Colitis - p. 572 72. Chemotherapy-Associated Colonic Injury - p. 579 73. Effects Of Bowel Preparation Agents - p. 580 74. Effects of Mucosal Prolapse In The Colon - p. 581 75. Behçet’s Syndrome - p. 585 76. Chapter 18. Inflammatory Disorders of the Appendix - p. 587 77. Section III. Polyps of the Gastrointestinal Tract - p. 613.e5 78. Chapter 19. Polyps of the Esophagus - p. 616 79. Chapter 20. Polyps of the Stomach - p. 628 80. Introduction - p. 628 81. Hyperplastic Polyps - p. 628 82. Ménétrier’s Disease - p. 636 83. Hamartomatous Polyps - p. 638 84. Embryonic Rests and Heterotopia - p. 646 85. Neoplastic Epithelial Polyps - p. 648 86. Nonepithelial Polyps - p. 658 87. Lymphoid Polyps - p. 661 88. Miscellaneous Rare Polyps and Polyp-Like Lesions - p. 661 89. Chapter 21. Polyps of the Small Intestine - p. 665 90. Chapter 22. Polyps of the Large Intestine - p. 693 91. Introduction - p. 693 92. Endoscopic Classification of Polyps - p. 694 93. Adenomatous Polyps - p. 694 94. Serrated Polyps - p. 703 95. Malignant Polyps - p. 714 96. Inflammatory Polyps - p. 718 97. Polyps Associated With Mucosal Prolapse - p. 719 98. Hamartomatous Polyps - p. 724 99. Visible Dysplastic Lesions in Inflammatory Bowel Disease - p. 733 100. Mesenchymal Polyps - p. 734 101. Miscellaneous Polypoid Lesions - p. 744 102. Section IV. Epithelial Neoplasms of the Gastrointestinal Tract - p. 749.e19 103. Chapter 23. Molecular Diagnostics of Tubal Gut Neoplasms - p. 752 104. Chapter 24. Epithelial Neoplasms of the Esophagus - p. 772 105. Chapter 25. Epithelial Neoplasms of the Stomach - p. 811 106. Introduction - p. 811 107. Pathogenesis - p. 812 108. Histological Precursors Of Gastric Carcinoma - p. 813 109. Early Gastric Carcinoma - p. 814 110. Advanced Gastric Carcinoma - p. 816 111. Major Histological Classifications Of Gastric Carcinoma - p. 818 112. Other Types Of Gastric Cancer - p. 826 113. Gastric Carcinoma In Special Clinical Circumstances - p. 828 114. Molecular Pathology Of Gastric Cancer - p. 829 115. Spread And Metastases - p. 834 116. Prognosis - p. 834 117. Management And Treatment - p. 834 118. Hereditary Gastric Cancer Syndromes - p. 836 119. Chapter 26. Epithelial Neoplasms of the Small Intestine - p. 845 120. Chapter 27. Epithelial Neoplasms of the Large Intestine - p. 860 121. Introduction - p. 861 122. Clinical Features - p. 861 123. Incidence - p. 861 124. Epidemiology - p. 863 125. Pathogenesis - p. 865 126. Gross Features and Specimen Handling - p. 870 127. Pathological Features - p. 873 128. Classification of Histological Subtypes - p. 874 129. Special Studies - p. 888 130. Differential Diagnosis - p. 890 131. Natural History - p. 891 132. Treatment - p. 891 133. Prognostic Factors - p. 895 134. Hereditary Colorectal Carcinoma - p. 909 135. Colorectal Cancer in Serrated Polyposis - p. 918 136. Colitis-Associated Neoplasia - p. 919 137. Chapter 28. Epithelial Neoplasms of the Appendix - p. 922 138. Chapter 29. Neuroendocrine Tumors of the Gastrointestinal and Pancreatobiliary Tracts - p. 951 139. Section V. Nonepithelial Neoplasms of the Gastrointestinal Tract - p. 970.e6 140. Chapter 30. Mesenchymal Tumors of the Gastrointestinal Tract - p. 972 141. Chapter 31. Hematolymphoid Tumors of the Gastrointestinal Tract, Hepatobiliary Tract, and Pancreas - p. 997 142. Introduction - p. 997 143. Gastric Marginal-Zone Lymphoma of Mucosa-Associated Lymphoid Tissue (Malt Lymphoma) - p. 998 144. Intestinal Marginal-Zone Lymphoma of Mucosa-Associated Lymphoid Tissue (Malt Lymphoma) - p. 1003 145. Immunoproliferative Small Intestinal Disease - p. 1004 146. Gastric Diffuse Large B-Cell Lymphoma - p. 1006 147. Intestinal Diffuse Large B-Cell Lymphoma - p. 1007 148. Mantle Cell Lymphoma - p. 1008 149. Duodenal-Type Follicular Lymphoma - p. 1010 150. Burkitt’s Lymphoma - p. 1012 151. Enteropathy-Associated T-Cell Lymphoma - p. 1014 152. Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma - p. 1016 153. Complicated Celiac Disease: Refractory Sprue and Ulcerative Jejunitis - p. 1018 154. Extranodal NK/T-Cell Lymphoma, Nasal Type - p. 1019 155. Other GI T-Cell Lymphomas - p. 1019 156. Indolent T-Cell Lymphoproliferative Disorder of the GI Tract - p. 1020 157. Appendiceal Lymphoma - p. 1021 158. Hodgkin Lymphoma of the GI Tract - p. 1022 159. GI Lymphoproliferative Disorders in Abnormal Immune States - p. 1023 160. Hepatic Lymphoma - p. 1026 161. Lymphomas of the Gallbladder - p. 1030 162. Lymphomas of the Extrahepatic Bile Ducts - p. 1030 163. Pancreatic Lymphoma - p. 1031 164. Proliferations of Histiocytes and Dendritic Cells in the GI Tract and Liver - p. 1032 165. Section VI. Anal Pathology - p. 1038.e12 166. Chapter 32. Inflammatory and Neoplastic Disorders of the Anal Canal - p. 1040 167. Part 2. Gallbladder, Extrahepatic Biliary Tract, and Pancreas - p. 1080.e9 168. Chapter 33. Algorithmic Approach to Diagnosis of Pancreatic Disorders - p. 1082 169. Chapter 34. Gallbladder, Extrahepatic Biliary Tract, and Pancreas Tissue Processing Techniques and Normal Histology - p. 1090 170. Chapter 35. Molecular Genetics of Pancreatobiliary Neoplasms - p. 1106 171. Chapter 36. Diagnostic Cytology of the Biliary Tract and Pancreas - p. 1119 172. Chapter 37. Developmental Disorders of the Gallbladder, Extrahepatic Biliary Tract, and Pancreas - p. 1154 173. Chapter 38. Infectious and Inflammatory Disorders of the Gallbladder and Extrahepatic Biliary Tract - p. 1169 174. Chapter 39. Benign and Malignant Tumors of the Gallbladder and Extrahepatic Biliary Tract - p. 1197 175. Introduction - p. 1197 176. Sampling of Gallbladder Specimens - p. 1197 177. Gallbladder - p. 1198 178. Extrahepatic Bile Ducts - p. 1226 179. Nonepithelial Tumors of the Gallbladder and Extrahepatic Bile Ducts - p. 1234 180. Secondary Tumors of the Gallbladder and Extrahepatic Bile Ducts - p. 1234 181. Chapter 40. Inflammatory and Other Nonneoplastic Disorders of the Pancreas - p. 1236 182. Chapter 41. Tumors of the Pancreas - p. 1265 183. Introduction And Classification - p. 1265 184. Ductal Adenocarcinoma And Variants - p. 1267 185. Pancreatic Intraepithelial Neoplasia - p. 1277 186. Intraductal Neoplasms - p. 1278 187. Cystic Neoplasms - p. 1284 188. Differential Diagnosis Of Cystic And Intraductal Lesions - p. 1290 189. Acinar Cell Carcinoma, Pancreatoblastoma, And Related Entities - p. 1291 190. Pancreatic Neuroendocrine Neoplasms - p. 1295 191. Solid Pseudopapillary Neoplasms - p. 1296 192. Differential Diagnosis Of Solid Cellular Neoplasms - p. 1297 193. Mesenchymal And Lymphoid Neoplasms - p. 1298 194. Tumor-Like Lesions - p. 1300 195. Secondary Tumors - p. 1301 196. Acknowledgment - p. 1301 197. Chapter 42. Tumors of Major and Minor Ampullae - p. 1302 198. Part 3. Liver - p. 1321.e6 199. Chapter 43. Algorithmic Approach to Diagnosis of Medical Liver Disorders - p. 1324 200. Chapter 44. Liver Tissue Processing and Normal Histology - p. 1352 201. Chapter 45. Molecular Pathogenesis and Diagnostics of Hepatocellular Tumors - p. 1369 202. Chapter 46. Diagnostic Cytology of the Liver - p. 1384 203. Chapter 47. Acute and Chronic Infectious Hepatitis - p. 1416 204. Introduction - p. 1416 205. Viral Hepatitis - p. 1416 206. Other Viral Infections Of The Liver - p. 1435 207. Bacterial Infections Of The Liver - p. 1440 208. Fungal Infections of the Liver - p. 1449 209. Parasitic Infections of the Liver - p. 1451 210. Chapter 48. Autoimmune and Chronic Cholestatic Disorders of the Liver - p. 1458 211. Introduction - p. 1458 212. Autoimmune Hepatitis - p. 1458 213. Primary Biliary Cholangitis - p. 1469 214. Primary Sclerosing Cholangitis - p. 1476 215. Overlap Syndromes - p. 1482 216. Immunoglobulin G4–Related Sclerosing Cholangitis - p. 1484 217. Immunoglobulin G4-Related Autoimmune Hepatitis - p. 1491 218. Secondary Sclerosing Cholangitis - p. 1492 219. Ischemic Cholangitis - p. 1492 220. Miscellaneous Ductopenic Syndromes - p. 1493 221. Obstructive Cholangitis - p. 1493 222. Post–Covid-19 Cholangiopathy - p. 1494 223. Chapter 49. Toxin- and Drug-Induced Disorders of the Liver - p. 1497 224. Introduction - p. 1497 225. Epidemiology - p. 1499 226. Clinical Assessment and Prediction of Hepatotoxicity - p. 1500 227. Prevention of Drug Hepatotoxicity - p. 1501 228. Treatment and Prognosis - p. 1502 229. Pathological Patterns of Toxic Liver Injury - p. 1503 230. Examples of Common Offending Drugs - p. 1527 231. Acknowledgments - p. 1543 232. Chapter 50. Fatty Liver Disease - p. 1544 233. Introduction - p. 1544 234. Alcohol-Induced Liver Disease - p. 1545 235. Nonalcoholic Fatty Liver Disease - p. 1553 236. Fatty Liver Disease in Various Patient Groups - p. 1567 237. Differentiating Alcoholic from Nonalcoholic Fatty Liver Disease - p. 1570 238. Grading and Staging of Fatty Liver Disease - p. 1571 239. Other Forms of Fatty Liver Disease - p. 1574 240. Chapter 51. Cirrhosis - p. 1577 241. Chapter 52. Vascular Disorders of the Liver - p. 1595 242. Chapter 53. Pathology of Liver and Hematopoietic Stem Cell Transplantation - p. 1627 243. Introduction - p. 1627 244. Donor Evaluation - p. 1628 245. Sources of Graft Dysfunction - p. 1632 246. Complications of Transplantation - p. 1638 247. Late Liver Allograft Dysfunction - p. 1667 248. Other Transplantation Effects - p. 1686 249. Acknowledgment - p. 1691 250. Chapter 54. Liver Pathology in Pregnancy - p. 1692 251. Chapter 55. Inherited Metabolic and Developmental Disorders of the Pediatric and Adult Liver - p. 1706 252. Introduction - p. 1707 253. Pediatric Liver Biopsies - p. 1707 254. Approach to the Diagnosis of Pediatric Liver Disorders in Liver Biopsies - p. 1711 255. Liver Diseases of Infancy - p. 1720 256. Paucity of Intrahepatic Bile Ducts - p. 1732 257. Hereditary Disorders of Bilirubin Metabolism - p. 1736 258. Hereditary Disorders of Bile Acid Metabolism and Bile Formation - p. 1737 259. Disorders of Carbohydrate Metabolism - p. 1745 260. Congenital Disorders of Glycosylation - p. 1749 261. Disorders of Amino Acid Metabolism - p. 1749 262. Disorders of Lipid Metabolism - p. 1750 263. Peroxisomal Disorders - p. 1754 264. Urea Cycle Disorders - p. 1757 265. Inherited and Metabolic Diseases of Adolescents And Adults - p. 1758 266. Abnormal Development of Liver Anatomy - p. 1766 267. Abnormal Development of the Biliary Tract - p. 1769 268. Conclusion - p. 1773 269. Chapter 56. Benign and Malignant Tumors of the Liver - p. 1774 270. Index - p. 1811
