Peptide and Peptidomimetic Therapeutics: From Bench to Beside offers applied, evidence-based instruction on developing and applying peptide therapeutics in disease treatment, driving drug discovery, and improving patient care. Here, researchers, clinicians and students will find tools to harness the full power of peptides and peptidomimetics and improve bioavailability, stability, efficiency and selectivity of new therapeutics and their application in treatment plans. More than 20 leaders in the field share their approaches for identifying and advancing peptide and peptidomimetic therapeutics. Topics examined run from "bench to bedside," beginning with fundamental peptide science, protein-protein interactions and peptide synthesis.
Later chapters examine modes for peptide drug delivery, including cell penetration peptide and peptidomimetic delivery, as well as the targeting of specific disease types, peptide therapeutics as applied to infectious disease, cancer, metabolic disorders, neurodegenerative disorders, and skin disorders, and antiparasitic and immunosuppressive peptidomimetics.
1. Peptide and Peptidomimetic Therapeutics - p. Page i 2. Cover - p. Page i 3. Title page - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iii 6. Contents - p. Page vi 7. List of contributors - p. Page vii 8. Preface - p. Page vii 9. List of Illustrations - p. Page xiii 10. List of Tables - p. Page xiv 11. Chapter 1 : Therapeutic peptides: historical perspectives and current development trends - p. Page xiv 12. Chapter 2 : Therapeutic peptidomimetics: targeting the undruggable space - p. Page 30 13. Chapter 3 : Tailoring peptides and peptidomimetics for targeting protein–protein interactions - p. Page 50 14. Chapter 4 : Advances in peptide synthesis - p. Page 67 15. Chapter 5 : Stapled peptidomimetic therapeutics - p. Page 91 16. Chapter 6 : Ring-closing metathesis/transannular cyclization to azabicyclo[X.Y.0]alkanone dipeptide turn mimics for biomedical applications - p. Page 120 17. Chapter 7 : The current state of backbone cyclic peptidomimetics and their application to drug discovery* - p. Page 147 18. Chapter 8 : Pharmacokinetics and pharmacodynamics of peptidomimetics - p. Page 186 19. Chapter 9 : Formulation of peptides and peptidomimetics - p. Page 207 20. Chapter 10 : Medical use of cell-penetrating peptides: how far have they come? - p. Page 230 21. Chapter 11 : Intracellular peptides as drug prototypes - p. Page 249 22. Chapter 12 : Applications of computational three-dimensional structure prediction for antimicrobial peptides - p. Page 281 23. Chapter 13 : Knottin peptidomimetics as therapeutics - p. Page 301 24. Chapter 14 : Venom peptides and peptidomimetics as therapeutics - p. Page 316 25. Chapter 15 : Therapeutic peptides targeting protein kinase: progress, challenges, and future directions, featuring cancer and cardiovascular disease - p. Page 329 26. Chapter 16 : Therapeutic peptidomimetics for infectious diseases - p. Page 350 27. Chapter 17 : Antiparasitic therapeutic peptidomimetics - p. Page 368 28. Chapter 18 : Peptides and antibiotic resistance - p. Page 405 29. Chapter 19 : Antimicrobial peptides and the skin and gut microbiomes - p. Page 430 30. Chapter 20 : Peptide and peptidomimetic-based vaccines - p. Page 453 31. Chapter 21 : Therapeutic peptidomimetics for cancer treatment - p. Page 468 32. Chapter 22 : Immunomodulatory peptidomimetics for multiple sclerosis therapy—the story of glatiramer acetate (Copaxone) - p. Page 501 33. Chapter 23 : Therapeutic peptidomimetics in metabolic diseases - p. Page 517 34. Chapter 24 : Peptide therapeutics in anesthesiology - p. Page 540 35. Chapter 25 : Cardiovascular-derived therapeutic peptidomimetics in cardiovascular disease - p. Page 573 36. Chapter 26 : Noncardiovascular-derived therapeutic peptidomimetics in cardiovascular disease - p. Page 602 37. Chapter 27 : Clinical and preclinical data on therapeutic peptides - p. Page 640 38. Chapter 28 : Therapeutic peptides: market and manufacturing - p. Page 677 39. Chapter 29 : Future perspectives on peptide therapeutics - p. Page 697 40. Index - p. Page 719
Peptide and Peptidomimetic Therapeutics: From Bench to Beside offers applied, evidence-based instruction on developing and applying peptide therapeutics in disease treatment, driving drug discovery, and improving patient care. Here, researchers, clinicians and students will find tools to harness the full power of peptides and peptidomimetics and improve bioavailability, stability, efficiency and selectivity of new therapeutics and their application in treatment plans. More than 20 leaders in the field share their approaches for identifying and advancing peptide and peptidomimetic therapeutics. Topics examined run from "bench to bedside," beginning with fundamental peptide science, protein-protein interactions and peptide synthesis.
Later chapters examine modes for peptide drug delivery, including cell penetration peptide and peptidomimetic delivery, as well as the targeting of specific disease types, peptide therapeutics as applied to infectious disease, cancer, metabolic disorders, neurodegenerative disorders, and skin disorders, and antiparasitic and immunosuppressive peptidomimetics.
1. Peptide and Peptidomimetic Therapeutics - p. Page i 2. Cover - p. Page i 3. Title page - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iii 6. Contents - p. Page vi 7. List of contributors - p. Page vii 8. Preface - p. Page vii 9. List of Illustrations - p. Page xiii 10. List of Tables - p. Page xiv 11. Chapter 1 : Therapeutic peptides: historical perspectives and current development trends - p. Page xiv 12. Chapter 2 : Therapeutic peptidomimetics: targeting the undruggable space - p. Page 30 13. Chapter 3 : Tailoring peptides and peptidomimetics for targeting protein–protein interactions - p. Page 50 14. Chapter 4 : Advances in peptide synthesis - p. Page 67 15. Chapter 5 : Stapled peptidomimetic therapeutics - p. Page 91 16. Chapter 6 : Ring-closing metathesis/transannular cyclization to azabicyclo[X.Y.0]alkanone dipeptide turn mimics for biomedical applications - p. Page 120 17. Chapter 7 : The current state of backbone cyclic peptidomimetics and their application to drug discovery* - p. Page 147 18. Chapter 8 : Pharmacokinetics and pharmacodynamics of peptidomimetics - p. Page 186 19. Chapter 9 : Formulation of peptides and peptidomimetics - p. Page 207 20. Chapter 10 : Medical use of cell-penetrating peptides: how far have they come? - p. Page 230 21. Chapter 11 : Intracellular peptides as drug prototypes - p. Page 249 22. Chapter 12 : Applications of computational three-dimensional structure prediction for antimicrobial peptides - p. Page 281 23. Chapter 13 : Knottin peptidomimetics as therapeutics - p. Page 301 24. Chapter 14 : Venom peptides and peptidomimetics as therapeutics - p. Page 316 25. Chapter 15 : Therapeutic peptides targeting protein kinase: progress, challenges, and future directions, featuring cancer and cardiovascular disease - p. Page 329 26. Chapter 16 : Therapeutic peptidomimetics for infectious diseases - p. Page 350 27. Chapter 17 : Antiparasitic therapeutic peptidomimetics - p. Page 368 28. Chapter 18 : Peptides and antibiotic resistance - p. Page 405 29. Chapter 19 : Antimicrobial peptides and the skin and gut microbiomes - p. Page 430 30. Chapter 20 : Peptide and peptidomimetic-based vaccines - p. Page 453 31. Chapter 21 : Therapeutic peptidomimetics for cancer treatment - p. Page 468 32. Chapter 22 : Immunomodulatory peptidomimetics for multiple sclerosis therapy—the story of glatiramer acetate (Copaxone) - p. Page 501 33. Chapter 23 : Therapeutic peptidomimetics in metabolic diseases - p. Page 517 34. Chapter 24 : Peptide therapeutics in anesthesiology - p. Page 540 35. Chapter 25 : Cardiovascular-derived therapeutic peptidomimetics in cardiovascular disease - p. Page 573 36. Chapter 26 : Noncardiovascular-derived therapeutic peptidomimetics in cardiovascular disease - p. Page 602 37. Chapter 27 : Clinical and preclinical data on therapeutic peptides - p. Page 640 38. Chapter 28 : Therapeutic peptides: market and manufacturing - p. Page 677 39. Chapter 29 : Future perspectives on peptide therapeutics - p. Page 697 40. Index - p. Page 719
