pH Deregulation as the Eleventh Hallmark of Cancer presents key concepts about pH deregulation in a concise and straight-forward manner. The book discusses topics such as pH regulation and metabolism, sodium hydrogen exchanger, monocarboxylate transporter, V-ATPase proton pump, carbonic anhydrases, and voltage gated sodium channels. In addition, it covers clinical and therapeutic implications and future perspectives. This is a valuable resource for researchers, oncologists, students and members of the biomedical and medical fields who want to learn more about the role of pH deregulation in cancer treatment.
pH deregulation can improve the outcome of classical treatments without adding toxicity to them, and the book shows that treating the pH peculiarities of cancer is simple and can be performed with existing drugs. Based on the classification of tumor malignancy in ten hallmarks, the authors put pH deregulation at the spotlight and separated from metabolic reprogramming due to its impact on all other hallmarks, proposing it as an additional characteristic to evaluate and fight cancer.
1. pH Deregulation as the Eleventh Hallmark of Cancer - p. i 2. Cover - p. i 3. Title Page - p. i 4. Copyright - p. iv 5. Table of Contents - p. iv 6. Dedication - p. v 7. Acknowledgment - p. ix 8. Chapter 1 pH Regulation and metabolism: Basic concepts - p. 1 9. Chapter 2 The pH gradient in cancer: pH deregulation - p. 15 10. Chapter 3 The pHtome - p. 33 11. Chapter 3.1 Na+/H+ exchangers (NHEs) - p. 39 12. Chapter 3.2 Voltage gated sodium channels (VGSCs) - p. 49 13. Chapter 3.3 Carbonic anhydrases (CAs) - p. 57 14. Chapter 3.4 The sodium bicarbonate cotransporter (NBC) family - p. 65 15. Chapter 3.5 Monocarboxylate transporters (MCTs) and lactate - p. 75 16. Chapter 3.6 The vacuolar type-ATPase proton pump - p. 81 17. Chapter 3.7 Voltage gated proton channel (Hv1) - p. 87 18. Chapter 4 Coordinated action of the pHtome: Integrating the cancer pH process - p. 93 19. Chapter 5 How pH deregulation favors the hallmarks of cancer - p. 101 20. Chapter 6 Deregulated pH: Therapeutic implications and treatment - p. 123 21. Chapter 7 Cancer metabolism and its interplay with pH - p. 137 22. Chapter 8 pH and drug resistance - p. 151 23. Chapter 9 Membrane proton sensing potentiates the pro-tumoral effects of extracellular acidity - p. 163 24. Chapter 10 Final words - p. 173 25. Index - p. 175
pH Deregulation as the Eleventh Hallmark of Cancer presents key concepts about pH deregulation in a concise and straight-forward manner. The book discusses topics such as pH regulation and metabolism, sodium hydrogen exchanger, monocarboxylate transporter, V-ATPase proton pump, carbonic anhydrases, and voltage gated sodium channels. In addition, it covers clinical and therapeutic implications and future perspectives. This is a valuable resource for researchers, oncologists, students and members of the biomedical and medical fields who want to learn more about the role of pH deregulation in cancer treatment.
pH deregulation can improve the outcome of classical treatments without adding toxicity to them, and the book shows that treating the pH peculiarities of cancer is simple and can be performed with existing drugs. Based on the classification of tumor malignancy in ten hallmarks, the authors put pH deregulation at the spotlight and separated from metabolic reprogramming due to its impact on all other hallmarks, proposing it as an additional characteristic to evaluate and fight cancer.
1. pH Deregulation as the Eleventh Hallmark of Cancer - p. i 2. Cover - p. i 3. Title Page - p. i 4. Copyright - p. iv 5. Table of Contents - p. iv 6. Dedication - p. v 7. Acknowledgment - p. ix 8. Chapter 1 pH Regulation and metabolism: Basic concepts - p. 1 9. Chapter 2 The pH gradient in cancer: pH deregulation - p. 15 10. Chapter 3 The pHtome - p. 33 11. Chapter 3.1 Na+/H+ exchangers (NHEs) - p. 39 12. Chapter 3.2 Voltage gated sodium channels (VGSCs) - p. 49 13. Chapter 3.3 Carbonic anhydrases (CAs) - p. 57 14. Chapter 3.4 The sodium bicarbonate cotransporter (NBC) family - p. 65 15. Chapter 3.5 Monocarboxylate transporters (MCTs) and lactate - p. 75 16. Chapter 3.6 The vacuolar type-ATPase proton pump - p. 81 17. Chapter 3.7 Voltage gated proton channel (Hv1) - p. 87 18. Chapter 4 Coordinated action of the pHtome: Integrating the cancer pH process - p. 93 19. Chapter 5 How pH deregulation favors the hallmarks of cancer - p. 101 20. Chapter 6 Deregulated pH: Therapeutic implications and treatment - p. 123 21. Chapter 7 Cancer metabolism and its interplay with pH - p. 137 22. Chapter 8 pH and drug resistance - p. 151 23. Chapter 9 Membrane proton sensing potentiates the pro-tumoral effects of extracellular acidity - p. 163 24. Chapter 10 Final words - p. 173 25. Index - p. 175
