Toxicodynamics in Drug Research, Volume 2: Public Health and Toxicology Issues examines the implications of public health issues and the impact of pharmaceuticals, chemical and food toxicants, dietary phytochemicals, and medical treatments on human health.
Volume 2: Public Health and Toxicology Issues in Drug Research: Toxicity and Toxicodynamics covers topics on pharmacokinetics and toxicokinetics such as population pharmacokinetics/toxicokinetics, the design of toxicokinetic studies, and the use of toxicokinetic data in preclinical safety assessments. The book investigates the health effect caused by the bioaccumulation of pharmaceutical and personal care products and the impact of drug-induced toxicity on different systems of the body. It discusses the mechanistic pathways of food toxicants and illustrates the molecular mechanisms of the chemopreventive role of dietary phytochemicals. It also delves into the toxic effects of medical treatments and materials. Ethical, legal, societal, and professional issues in toxicology round off the coverage providing a valuable resource to interested in learning more about the health impact and public health issues related to the toxicity of pharmaceuticals, dietary supplements, personal care products, and medical treatments.
1. Public Health and Toxicology Issues in Drug Research, Volume 2 - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Contributors - p. Page iv 7. List of Illustrations - p. Page vii 8. List of Tables - p. Page viii 9. Chapter 1 : Biomarkers: Revolutionizing disease monitoring and therapeutic strategies - p. Page viii 10. Chapter 2 : Connecting biotransformation with toxicity - p. Page 19 11. Chapter 3 : Idiosyncratic drug reactions and toxicities - p. Page 50 12. Chapter 4 : Importance of dose selection in toxicity studies - p. Page 80 13. Chapter 5 : Implication of sex differences in toxicology - p. Page 115 14. Chapter 6 : Toxicological risk assessment and risk management - p. Page 138 15. Chapter 7 : Adverse outcome pathway: A paradigm shift in chemical toxicological analysis - p. Page 162 16. Chapter 8 : Design of toxicokinetic studies - p. Page 197 17. Chapter 9 : Use of toxicokinetic data in preclinical safety assessment - p. Page 221 18. Chapter 10 : Drug-induced cardiotoxicity - p. Page 244 19. Chapter 11 : Drug-induced immunotoxicity - p. Page 275 20. Chapter 12 : Drug-induced photosensitivity - p. Page 317 21. Chapter 13 : Toxic effects of cancer therapies - p. Page 347 22. Chapter 14 : High content screening in toxicology - p. Page 375 23. Chapter 15 : High-throughput screening in toxicity assessment - p. Page 401 24. Chapter 16 : Population pharmacokinetics/toxicokinetics - p. Page 443 25. Chapter 17 : Quantitative extrapolation interspecies scaling/low-dose extrapolation - p. Page 467 26. Chapter 18 : Toxicity and toxicodynamics of cryoprotectant used in pharmaceutical products - p. Page 488 27. Chapter 19 : Insect repellents as an environmental chemical toxicant to human health - p. Page 516 28. Chapter 20 : Clinical toxicity of antibody–drug conjugates - p. Page 548 29. Chapter 21 : Cumulative toxicity of herbal drugs - p. Page 581 30. Chapter 22 : Radiotherapy toxicity - p. Page 611 31. Chapter 23 : Toxicities and toxicodynamic of anesthetics - p. Page 641 32. Chapter 24 : Toxicity of nanomaterials - p. Page 671 33. Chapter 25 : Principles of management of acute poisoning - p. Page 702 34. Chapter 26 : Connecting link between pesticides and Parkinson's disease - p. Page 730 35. Chapter 27 : Psychopharmacology in late life: Key challenges and opportunities - p. Page 750 36. Chapter 28 : Ethical, legal, societal, and professional issues in toxicology - p. Page 778 37. Index - p. Page 798
Toxicodynamics in Drug Research, Volume 2: Public Health and Toxicology Issues examines the implications of public health issues and the impact of pharmaceuticals, chemical and food toxicants, dietary phytochemicals, and medical treatments on human health.
Volume 2: Public Health and Toxicology Issues in Drug Research: Toxicity and Toxicodynamics covers topics on pharmacokinetics and toxicokinetics such as population pharmacokinetics/toxicokinetics, the design of toxicokinetic studies, and the use of toxicokinetic data in preclinical safety assessments. The book investigates the health effect caused by the bioaccumulation of pharmaceutical and personal care products and the impact of drug-induced toxicity on different systems of the body. It discusses the mechanistic pathways of food toxicants and illustrates the molecular mechanisms of the chemopreventive role of dietary phytochemicals. It also delves into the toxic effects of medical treatments and materials. Ethical, legal, societal, and professional issues in toxicology round off the coverage providing a valuable resource to interested in learning more about the health impact and public health issues related to the toxicity of pharmaceuticals, dietary supplements, personal care products, and medical treatments.
1. Public Health and Toxicology Issues in Drug Research, Volume 2 - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Contributors - p. Page iv 7. List of Illustrations - p. Page vii 8. List of Tables - p. Page viii 9. Chapter 1 : Biomarkers: Revolutionizing disease monitoring and therapeutic strategies - p. Page viii 10. Chapter 2 : Connecting biotransformation with toxicity - p. Page 19 11. Chapter 3 : Idiosyncratic drug reactions and toxicities - p. Page 50 12. Chapter 4 : Importance of dose selection in toxicity studies - p. Page 80 13. Chapter 5 : Implication of sex differences in toxicology - p. Page 115 14. Chapter 6 : Toxicological risk assessment and risk management - p. Page 138 15. Chapter 7 : Adverse outcome pathway: A paradigm shift in chemical toxicological analysis - p. Page 162 16. Chapter 8 : Design of toxicokinetic studies - p. Page 197 17. Chapter 9 : Use of toxicokinetic data in preclinical safety assessment - p. Page 221 18. Chapter 10 : Drug-induced cardiotoxicity - p. Page 244 19. Chapter 11 : Drug-induced immunotoxicity - p. Page 275 20. Chapter 12 : Drug-induced photosensitivity - p. Page 317 21. Chapter 13 : Toxic effects of cancer therapies - p. Page 347 22. Chapter 14 : High content screening in toxicology - p. Page 375 23. Chapter 15 : High-throughput screening in toxicity assessment - p. Page 401 24. Chapter 16 : Population pharmacokinetics/toxicokinetics - p. Page 443 25. Chapter 17 : Quantitative extrapolation interspecies scaling/low-dose extrapolation - p. Page 467 26. Chapter 18 : Toxicity and toxicodynamics of cryoprotectant used in pharmaceutical products - p. Page 488 27. Chapter 19 : Insect repellents as an environmental chemical toxicant to human health - p. Page 516 28. Chapter 20 : Clinical toxicity of antibody–drug conjugates - p. Page 548 29. Chapter 21 : Cumulative toxicity of herbal drugs - p. Page 581 30. Chapter 22 : Radiotherapy toxicity - p. Page 611 31. Chapter 23 : Toxicities and toxicodynamic of anesthetics - p. Page 641 32. Chapter 24 : Toxicity of nanomaterials - p. Page 671 33. Chapter 25 : Principles of management of acute poisoning - p. Page 702 34. Chapter 26 : Connecting link between pesticides and Parkinson's disease - p. Page 730 35. Chapter 27 : Psychopharmacology in late life: Key challenges and opportunities - p. Page 750 36. Chapter 28 : Ethical, legal, societal, and professional issues in toxicology - p. Page 778 37. Index - p. Page 798
