Rheumatology Secrets
1. Introduction - p. 1 2. Chapter 1. Classification and Health Impact of the Rheumatic Diseases - p. 2 3. Chapter 2. Top 100+ Rheumatology Secrets - p. 6 4. Chapter 3. Anatomy and Physiology of the Musculoskeletal System - p. 17 5. Chapter 4. Overview of the Immune Response, Inflammation, and Autoimmunity - p. 26 6. II. Evaluation of the Patient with Rheumatic Symptoms - p. 40 7. Introduction - p. 41 8. Chapter 5. History and Physical Examination - p. 42 9. Chapter 6. Laboratory Evaluation - p. 51 10. Chapter 7. Arthrocentesis and Synovial Fluid Analysis - p. 63 11. Chapter 8. Radiographic and Imaging Modalities - p. 68 12. Chapter 9. Synovial Biopsies - p. 82 13. Chapter 10. Electromyography and Nerve Conduction Studies - p. 85 14. Chapter 11. Approach for Patients with Monoarticular Arthritis Symptoms - p. 89 15. Chapter 12. Approach for Patients with Polyarticular Arthritis Symptoms - p. 94 16. Chapter 13. Approach to the Patient with Neuromuscular Symptoms - p. 100 17. Chapter 14. Perioperative Management of Patients with Rheumatic Diseases - p. 106 18. III. Systemic Connective Tissue Diseases - p. 115 19. Introduction - p. 117 20. Chapter 15. Rheumatoid Arthritis - p. 118 21. Chapter 16. Systemic Lupus Erythematosus - p. 131 22. Chapter 17. Drug-induced Lupus Erythematosus - p. 152 23. Chapter 18. Systemic Sclerosis - p. 156 24. Chapter 19. Scleroderma Mimics - p. 171 25. Chapter 20. Idiopathic Inflammatory Myopathies - p. 177 26. Chapter 21. Mixed Connective Tissue Disease, Overlap Syndromes, and Undifferentiated Connective Tissue Disease - p. 185 27. Chapter 22. Sjögren’s Syndrome - p. 190 28. Chapter 23. Antiphospholipid Antibody Syndrome - p. 198 29. Chapter 24. Adult-Onset Still’s Disease - p. 209 30. Chapter 25. Polymyalgia Rheumatica - p. 214 31. IV. The Vasculitides and Related Disorders - p. 218 32. Introduction - p. 219 33. Chapter 26. Approach for Patients with Suspected Vasculitis - p. 220 34. Chapter 27. Large-Vessel Vasculitis: Giant Cell Arteritis, Takayasu Arteritis, and Aortitis - p. 227 35. Chapter 28. Medium-Vessel Vasculitides: Polyarteritis Nodosa, Thromboangiitis Obliterans, and Primary Angiitis of the Central Nervous System - p. 236 36. Chapter 29. Antineutrophil Cytoplasmic Antibody-Associated Vasculitis - p. 245 37. Chapter 30. Immune Complex-Mediated Small-Vessel Vasculitides - p. 258 38. Chapter 31. Cryoglobulinemia - p. 264 39. Chapter 32. Behçet’s Disease and Cogan’s Syndrome - p. 271 40. Chapter 33. Relapsing Polychondritis - p. 277 41. V. Seronegative Spondyloarthropathies - p. 282 42. Introduction - p. 283 43. Chapter 34. Axial Spondyloarthritis - p. 284 44. Chapter 35. Rheumatic Manifestations of Gastrointestinal and Hepatobiliary Diseases - p. 291 45. Chapter 36. Reactive Arthritis - p. 298 46. Chapter 37. Arthritis Associated with Psoriasis and Other Skin Diseases - p. 308 47. VI. Arthritis Associated with Infectious Agents - p. 314 48. Introduction - p. 315 49. Chapter 38. Bacterial Septic Arthritis, Bursitis, and Osteomyelitis - p. 316 50. Chapter 39. Lyme Disease - p. 325 51. Chapter 40. Mycobacterial and Fungal Joint and Bone Diseases - p. 333 52. Chapter 41. Viral Arthritides - p. 340 53. Chapter 42. HIV-Associated Rheumatic Syndromes - p. 346 54. Chapter 43. Whipple’s Disease - p. 352 55. Chapter 44. Acute Rheumatic Fever and Poststreptococcal Arthritis - p. 357 56. VII. Rheumatic Disorders Associated with Metabolic, Endocrine, and Hematologic Diseases - p. 362 57. Introduction - p. 363 58. Chapter 45. Gout - p. 364 59. Chapter 46. Calcium Pyrophosphate Deposition Disease - p. 373 60. Chapter 47. Basic Calcium Phosphate and Other Crystalline Diseases - p. 380 61. Chapter 48. Endocrine-Associated Arthropathies - p. 386 62. Chapter 49. Arthropathies Associated with Hematologic Diseases - p. 394 63. Chapter 50. Malignancy-Associated Rheumatic Disorders - p. 400 64. VIII. Bone and Cartilage Disorders - p. 407 65. Introduction - p. 409 66. Chapter 51. Osteoarthritis - p. 410 67. Chapter 52. Metabolic Bone Disease - p. 421 68. Chapter 53. Paget’s Disease of Bone - p. 430 69. Chapter 54. Osteonecrosis - p. 435 70. IX. Hereditary, Congenital, and Inborn Errors of Metabolism Associated with Rheumatic Syndromes - p. 440 71. Introduction - p. 441 72. Chapter 55. Heritable Connective Tissue Diseases - p. 442 73. Chapter 56. Inborn Errors of Metabolism Affecting Connective Tissue - p. 450 74. Chapter 57. Storage and Deposition Diseases - p. 454 75. Chapter 58. Rheumatologic Manifestations of the Primary Immunodeficiency Syndromes - p. 460 76. Chapter 59. Bone and Joint Dysplasias - p. 467 77. X. Nonarticular and Regional Musculoskeletal Disorders - p. 472 78. Introduction - p. 473 79. Chapter 60. Approach for the Patient with Neck and Low Back Pain - p. 474 80. Chapter 61. Fibromyalgia - p. 481 81. Chapter 62. Regional Musculoskeletal Disorders - p. 490 82. Chapter 63. Sports Medicine and Occupational Injuries - p. 499 83. Chapter 64. Entrapment Neuropathies - p. 506 84. Chapter 65. Complex Regional Pain Syndrome - p. 512 85. XI. Neoplasms and Tumorlike Lesions - p. 518 86. Introduction - p. 519 87. Chapter 66. Benign and Malignant Tumors of Joints and Synovium - p. 520 88. Chapter 67. Common Bony Lesions: Radiographic Features - p. 524 89. XII. Pediatric Rheumatic Diseases - p. 538 90. Introduction - p. 539 91. Chapter 68. Approach to the Child with Joint Pain - p. 540 92. Chapter 69. Juvenile Idiopathic Arthritis - p. 547 93. Chapter 70. Juvenile Systemic Connective Tissue Diseases - p. 554 94. Chapter 71. Kawasaki Disease - p. 562 95. XIII. Miscellaneous Rheumatic Disorders - p. 565 96. Introduction - p. 567 97. Chapter 72. Metabolic and Other Genetic Myopathies - p. 568 98. Chapter 73. Amyloidosis - p. 577 99. Chapter 74. Raynaud’s Phenomenon - p. 583 100. Chapter 75. Autoimmune Eye and Ear Disorders - p. 589 101. Chapter 76. Rheumatic Syndromes Associated with Sarcoidosis - p. 601 102. Chapter 77. Rheumatic Disorders in Patients on Dialysis - p. 608 103. Chapter 78. Rheumatic Disease and the Pregnant Patient - p. 614 104. Chapter 79. Periodic Fever and Autoinflammatory Syndromes - p. 623 105. Chapter 80. Odds and Ends - p. 633 106. XIV. Management of the Rheumatic Diseases - p. 643 107. Introduction - p. 645 108. Chapter 81. Nonsteroidal Antiinflammatory Drugs - p. 646 109. Chapter 82. Glucocorticoids—Systemic and Injectable - p. 655 110. Chapter 83. Systemic Antirheumatic Drugs - p. 662 111. Chapter 84. Immunosuppressive, Target-Specific, and Immunoregulatory Agents - p. 671 112. Chapter 85. Biologic Agents - p. 680 113. Chapter 86. Hypouricemic Agents and Colchicine - p. 692 114. Chapter 87. Bone-Strengthening Agents - p. 699 115. Chapter 88. Rehabilitative Techniques - p. 710 116. Chapter 89. Surgical Treatment and Rheumatic Diseases - p. 716 117. Chapter 90. Disability - p. 724 118. XV. Final Secrets - p. 729 119. Introduction - p. 731 120. Chapter 91. Complementary and Alternative Medicine - p. 732 121. Chapter 92. History, the Arts, and Rheumatic Diseases - p. 740 122. XVI. Board-style Questions - p. 744 123. Question Bank - p. e1 124. Index - p. 745
Rheumatology Secrets
1. Introduction - p. 1 2. Chapter 1. Classification and Health Impact of the Rheumatic Diseases - p. 2 3. Chapter 2. Top 100+ Rheumatology Secrets - p. 6 4. Chapter 3. Anatomy and Physiology of the Musculoskeletal System - p. 17 5. Chapter 4. Overview of the Immune Response, Inflammation, and Autoimmunity - p. 26 6. II. Evaluation of the Patient with Rheumatic Symptoms - p. 40 7. Introduction - p. 41 8. Chapter 5. History and Physical Examination - p. 42 9. Chapter 6. Laboratory Evaluation - p. 51 10. Chapter 7. Arthrocentesis and Synovial Fluid Analysis - p. 63 11. Chapter 8. Radiographic and Imaging Modalities - p. 68 12. Chapter 9. Synovial Biopsies - p. 82 13. Chapter 10. Electromyography and Nerve Conduction Studies - p. 85 14. Chapter 11. Approach for Patients with Monoarticular Arthritis Symptoms - p. 89 15. Chapter 12. Approach for Patients with Polyarticular Arthritis Symptoms - p. 94 16. Chapter 13. Approach to the Patient with Neuromuscular Symptoms - p. 100 17. Chapter 14. Perioperative Management of Patients with Rheumatic Diseases - p. 106 18. III. Systemic Connective Tissue Diseases - p. 115 19. Introduction - p. 117 20. Chapter 15. Rheumatoid Arthritis - p. 118 21. Chapter 16. Systemic Lupus Erythematosus - p. 131 22. Chapter 17. Drug-induced Lupus Erythematosus - p. 152 23. Chapter 18. Systemic Sclerosis - p. 156 24. Chapter 19. Scleroderma Mimics - p. 171 25. Chapter 20. Idiopathic Inflammatory Myopathies - p. 177 26. Chapter 21. Mixed Connective Tissue Disease, Overlap Syndromes, and Undifferentiated Connective Tissue Disease - p. 185 27. Chapter 22. Sjögren’s Syndrome - p. 190 28. Chapter 23. Antiphospholipid Antibody Syndrome - p. 198 29. Chapter 24. Adult-Onset Still’s Disease - p. 209 30. Chapter 25. Polymyalgia Rheumatica - p. 214 31. IV. The Vasculitides and Related Disorders - p. 218 32. Introduction - p. 219 33. Chapter 26. Approach for Patients with Suspected Vasculitis - p. 220 34. Chapter 27. Large-Vessel Vasculitis: Giant Cell Arteritis, Takayasu Arteritis, and Aortitis - p. 227 35. Chapter 28. Medium-Vessel Vasculitides: Polyarteritis Nodosa, Thromboangiitis Obliterans, and Primary Angiitis of the Central Nervous System - p. 236 36. Chapter 29. Antineutrophil Cytoplasmic Antibody-Associated Vasculitis - p. 245 37. Chapter 30. Immune Complex-Mediated Small-Vessel Vasculitides - p. 258 38. Chapter 31. Cryoglobulinemia - p. 264 39. Chapter 32. Behçet’s Disease and Cogan’s Syndrome - p. 271 40. Chapter 33. Relapsing Polychondritis - p. 277 41. V. Seronegative Spondyloarthropathies - p. 282 42. Introduction - p. 283 43. Chapter 34. Axial Spondyloarthritis - p. 284 44. Chapter 35. Rheumatic Manifestations of Gastrointestinal and Hepatobiliary Diseases - p. 291 45. Chapter 36. Reactive Arthritis - p. 298 46. Chapter 37. Arthritis Associated with Psoriasis and Other Skin Diseases - p. 308 47. VI. Arthritis Associated with Infectious Agents - p. 314 48. Introduction - p. 315 49. Chapter 38. Bacterial Septic Arthritis, Bursitis, and Osteomyelitis - p. 316 50. Chapter 39. Lyme Disease - p. 325 51. Chapter 40. Mycobacterial and Fungal Joint and Bone Diseases - p. 333 52. Chapter 41. Viral Arthritides - p. 340 53. Chapter 42. HIV-Associated Rheumatic Syndromes - p. 346 54. Chapter 43. Whipple’s Disease - p. 352 55. Chapter 44. Acute Rheumatic Fever and Poststreptococcal Arthritis - p. 357 56. VII. Rheumatic Disorders Associated with Metabolic, Endocrine, and Hematologic Diseases - p. 362 57. Introduction - p. 363 58. Chapter 45. Gout - p. 364 59. Chapter 46. Calcium Pyrophosphate Deposition Disease - p. 373 60. Chapter 47. Basic Calcium Phosphate and Other Crystalline Diseases - p. 380 61. Chapter 48. Endocrine-Associated Arthropathies - p. 386 62. Chapter 49. Arthropathies Associated with Hematologic Diseases - p. 394 63. Chapter 50. Malignancy-Associated Rheumatic Disorders - p. 400 64. VIII. Bone and Cartilage Disorders - p. 407 65. Introduction - p. 409 66. Chapter 51. Osteoarthritis - p. 410 67. Chapter 52. Metabolic Bone Disease - p. 421 68. Chapter 53. Paget’s Disease of Bone - p. 430 69. Chapter 54. Osteonecrosis - p. 435 70. IX. Hereditary, Congenital, and Inborn Errors of Metabolism Associated with Rheumatic Syndromes - p. 440 71. Introduction - p. 441 72. Chapter 55. Heritable Connective Tissue Diseases - p. 442 73. Chapter 56. Inborn Errors of Metabolism Affecting Connective Tissue - p. 450 74. Chapter 57. Storage and Deposition Diseases - p. 454 75. Chapter 58. Rheumatologic Manifestations of the Primary Immunodeficiency Syndromes - p. 460 76. Chapter 59. Bone and Joint Dysplasias - p. 467 77. X. Nonarticular and Regional Musculoskeletal Disorders - p. 472 78. Introduction - p. 473 79. Chapter 60. Approach for the Patient with Neck and Low Back Pain - p. 474 80. Chapter 61. Fibromyalgia - p. 481 81. Chapter 62. Regional Musculoskeletal Disorders - p. 490 82. Chapter 63. Sports Medicine and Occupational Injuries - p. 499 83. Chapter 64. Entrapment Neuropathies - p. 506 84. Chapter 65. Complex Regional Pain Syndrome - p. 512 85. XI. Neoplasms and Tumorlike Lesions - p. 518 86. Introduction - p. 519 87. Chapter 66. Benign and Malignant Tumors of Joints and Synovium - p. 520 88. Chapter 67. Common Bony Lesions: Radiographic Features - p. 524 89. XII. Pediatric Rheumatic Diseases - p. 538 90. Introduction - p. 539 91. Chapter 68. Approach to the Child with Joint Pain - p. 540 92. Chapter 69. Juvenile Idiopathic Arthritis - p. 547 93. Chapter 70. Juvenile Systemic Connective Tissue Diseases - p. 554 94. Chapter 71. Kawasaki Disease - p. 562 95. XIII. Miscellaneous Rheumatic Disorders - p. 565 96. Introduction - p. 567 97. Chapter 72. Metabolic and Other Genetic Myopathies - p. 568 98. Chapter 73. Amyloidosis - p. 577 99. Chapter 74. Raynaud’s Phenomenon - p. 583 100. Chapter 75. Autoimmune Eye and Ear Disorders - p. 589 101. Chapter 76. Rheumatic Syndromes Associated with Sarcoidosis - p. 601 102. Chapter 77. Rheumatic Disorders in Patients on Dialysis - p. 608 103. Chapter 78. Rheumatic Disease and the Pregnant Patient - p. 614 104. Chapter 79. Periodic Fever and Autoinflammatory Syndromes - p. 623 105. Chapter 80. Odds and Ends - p. 633 106. XIV. Management of the Rheumatic Diseases - p. 643 107. Introduction - p. 645 108. Chapter 81. Nonsteroidal Antiinflammatory Drugs - p. 646 109. Chapter 82. Glucocorticoids—Systemic and Injectable - p. 655 110. Chapter 83. Systemic Antirheumatic Drugs - p. 662 111. Chapter 84. Immunosuppressive, Target-Specific, and Immunoregulatory Agents - p. 671 112. Chapter 85. Biologic Agents - p. 680 113. Chapter 86. Hypouricemic Agents and Colchicine - p. 692 114. Chapter 87. Bone-Strengthening Agents - p. 699 115. Chapter 88. Rehabilitative Techniques - p. 710 116. Chapter 89. Surgical Treatment and Rheumatic Diseases - p. 716 117. Chapter 90. Disability - p. 724 118. XV. Final Secrets - p. 729 119. Introduction - p. 731 120. Chapter 91. Complementary and Alternative Medicine - p. 732 121. Chapter 92. History, the Arts, and Rheumatic Diseases - p. 740 122. XVI. Board-style Questions - p. 744 123. Question Bank - p. e1 124. Index - p. 745