RNases in Health and Diseases: From Housekeeping Enzymes to Moonlight Proteins provides coverage of the structural and functional properties of RNases, introducing new concepts such as their recently discovered multifaceted properties, their involvement in the generation of non-coding signaling RNAs, and their proposed uses as diagnostic and therapeutic tools. This book's sections cover the structure of RNases, present research methods and tools to study RNases, and delve into RNases and diseases. Users will find a wider perspective on the topics discussed that will serve researchers and students engaged in the study of RNases who are interested in acquiring a better understanding.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. ix 7. About main contributing authors - p. xi 8. Preface - p. xiii 9. Acknowledgments - p. xv 10. Section I: Ribonucleases structure–function - p. S1 11. Chapter 1. Overview: ribonucleases, a family of multifaceted proteins - p. 3 12. Chapter 2. Catalytic mechanism of action and substrate-binding sites - p. 25 13. Chapter 3. Experimental tools for studying ribonucleases activities - p. 45 14. Chapter 4. The credentials for Ribonuclease A to be catalytically active: The prerequisite of oxidative protein folding - p. 55 15. Chapter 5. Ribonucleases in evolution - p. 71 16. Chapter 6. From monomers to multimers - p. 101 17. Chapter 7. Ribonucleases targeting noncoding RNAs - p. 131 18. Section II: Ribonucleases in diseases - p. S165 19. Chapter 8. Ribonucleases in infectious diseases - p. 167 20. Chapter 9. Ribonucleases, cellular signaling and inflammation - p. 197 21. Chapter 10. Ribonucleases in gut diseases - p. 223 22. Chapter 11. Human natural variants - p. 239 23. Chapter 12. Ribonucleases and drug design - p. 249 24. Index - p. 271
RNases in Health and Diseases: From Housekeeping Enzymes to Moonlight Proteins provides coverage of the structural and functional properties of RNases, introducing new concepts such as their recently discovered multifaceted properties, their involvement in the generation of non-coding signaling RNAs, and their proposed uses as diagnostic and therapeutic tools. This book's sections cover the structure of RNases, present research methods and tools to study RNases, and delve into RNases and diseases. Users will find a wider perspective on the topics discussed that will serve researchers and students engaged in the study of RNases who are interested in acquiring a better understanding.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. ix 7. About main contributing authors - p. xi 8. Preface - p. xiii 9. Acknowledgments - p. xv 10. Section I: Ribonucleases structure–function - p. S1 11. Chapter 1. Overview: ribonucleases, a family of multifaceted proteins - p. 3 12. Chapter 2. Catalytic mechanism of action and substrate-binding sites - p. 25 13. Chapter 3. Experimental tools for studying ribonucleases activities - p. 45 14. Chapter 4. The credentials for Ribonuclease A to be catalytically active: The prerequisite of oxidative protein folding - p. 55 15. Chapter 5. Ribonucleases in evolution - p. 71 16. Chapter 6. From monomers to multimers - p. 101 17. Chapter 7. Ribonucleases targeting noncoding RNAs - p. 131 18. Section II: Ribonucleases in diseases - p. S165 19. Chapter 8. Ribonucleases in infectious diseases - p. 167 20. Chapter 9. Ribonucleases, cellular signaling and inflammation - p. 197 21. Chapter 10. Ribonucleases in gut diseases - p. 223 22. Chapter 11. Human natural variants - p. 239 23. Chapter 12. Ribonucleases and drug design - p. 249 24. Index - p. 271
