The smallest possible saturated azaheterocycle, aziridine, is well-known to organic chemists for its tremendous potential in pharmaceutical chemistry and organic synthesis. The general biological importance of aziridines is proven by the fact that they found several uses as subunits in pharmacologically active compounds such as antitumor agents, enzyme inhibitors, and antibiotics. Although aziridines are highly reactive, this framework occurs in many synthetic compounds and the natural products of biological interest also contain aziridine skeleton in their structures.
The synthetic community is captivated with prospects of selective synthesis and conversions of aziridines. Several important advances in this area have been witnessed in recent years and discovering efficient novel methods for the synthesis of aziridines has been very active field of research. Its powerful synthetic utility has been described by an overpowering amount of documentation on the approaches for the formation of aziridine.
Synthesis of Aziridines and Oxaziridines from Imines describes the new and old methods for the synthesis of aziridines from imines and covers an important and rapidly growing branch of heterocyclic chemistry. Readers will have access to different methods and information allowing them to evaluate which method is most suitable for particular cases.
1. Synthesis of Aziridines and Oxaziridines from Imines - p. Page i 2. Cover - p. Page i 3. Title page - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iii 6. Contents - p. Page vi 7. About the author - p. Page vi 8. Preface - p. Page viii 9. Abbreviations - p. Page ix 10. List of Illustrations - p. Page xiii 11. 1 : Aziridine synthesis from imines-I - p. Page xiii 12. 2 : Aziridine synthesis from imines-II - p. Page 22 13. 3 : Aziridine synthesis by condensation of phenylimines with ethyl diazoacetate - p. Page 44 14. 4 : Aziridine synthesis by metal-catalyzed condensation of phenylimines with ethyl diazoacetate - p. Page 73 15. 5 : Aziridine synthesis by the addition of biphenyl imines to ethyl diazoacetate - p. Page 95 16. 6 : Aziridine synthesis by metal-catalyzed addition of biphenyl imines to ethyl diazoacetate - p. Page 119 17. 7 : Aziridine synthesis by condensation of imines with diazo compounds - p. Page 141 18. 8 : Aziridine synthesis by condensation of imines with diazomethane - p. Page 169 19. 9 : Aziridine synthesis by ring-closure of haloimines - p. Page 192 20. 10 : Aziridine synthesis by ring-closure of imines and halo compounds - p. Page 208 21. 11 : Aziridine synthesis by alkene-imine and alkyne-imine reactions - p. Page 235 22. 12 : Oxaziridine synthesis from imines - p. Page 260 23. 13 : Oxaziridine synthesis from imines using meta-chloroperoxybenzoic acid - p. Page 289 24. Index - p. Page 316
The smallest possible saturated azaheterocycle, aziridine, is well-known to organic chemists for its tremendous potential in pharmaceutical chemistry and organic synthesis. The general biological importance of aziridines is proven by the fact that they found several uses as subunits in pharmacologically active compounds such as antitumor agents, enzyme inhibitors, and antibiotics. Although aziridines are highly reactive, this framework occurs in many synthetic compounds and the natural products of biological interest also contain aziridine skeleton in their structures.
The synthetic community is captivated with prospects of selective synthesis and conversions of aziridines. Several important advances in this area have been witnessed in recent years and discovering efficient novel methods for the synthesis of aziridines has been very active field of research. Its powerful synthetic utility has been described by an overpowering amount of documentation on the approaches for the formation of aziridine.
Synthesis of Aziridines and Oxaziridines from Imines describes the new and old methods for the synthesis of aziridines from imines and covers an important and rapidly growing branch of heterocyclic chemistry. Readers will have access to different methods and information allowing them to evaluate which method is most suitable for particular cases.
1. Synthesis of Aziridines and Oxaziridines from Imines - p. Page i 2. Cover - p. Page i 3. Title page - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iii 6. Contents - p. Page vi 7. About the author - p. Page vi 8. Preface - p. Page viii 9. Abbreviations - p. Page ix 10. List of Illustrations - p. Page xiii 11. 1 : Aziridine synthesis from imines-I - p. Page xiii 12. 2 : Aziridine synthesis from imines-II - p. Page 22 13. 3 : Aziridine synthesis by condensation of phenylimines with ethyl diazoacetate - p. Page 44 14. 4 : Aziridine synthesis by metal-catalyzed condensation of phenylimines with ethyl diazoacetate - p. Page 73 15. 5 : Aziridine synthesis by the addition of biphenyl imines to ethyl diazoacetate - p. Page 95 16. 6 : Aziridine synthesis by metal-catalyzed addition of biphenyl imines to ethyl diazoacetate - p. Page 119 17. 7 : Aziridine synthesis by condensation of imines with diazo compounds - p. Page 141 18. 8 : Aziridine synthesis by condensation of imines with diazomethane - p. Page 169 19. 9 : Aziridine synthesis by ring-closure of haloimines - p. Page 192 20. 10 : Aziridine synthesis by ring-closure of imines and halo compounds - p. Page 208 21. 11 : Aziridine synthesis by alkene-imine and alkyne-imine reactions - p. Page 235 22. 12 : Oxaziridine synthesis from imines - p. Page 260 23. 13 : Oxaziridine synthesis from imines using meta-chloroperoxybenzoic acid - p. Page 289 24. Index - p. Page 316
