Offering a concise, highly visual approach to the basic science and clinical pathology of the musculoskeletal system, this updated volume in The Netter Collection of Medical Illustrations (the CIBA "Green Books") contains unparalleled didactic illustrations reflecting the latest medical knowledge. Revised by Drs. Joseph Iannotti, Richard Parker, Abby G. Abelson, Brendan M. Patterson, and other experts from the Cleveland Clinic, Biology and Systemic Diseases, Part 3 of Musculoskeletal System, Volume 6, integrates core concepts of anatomy, physiology, and other basic sciences with common clinical correlates across health, medical, and surgical disciplines. Classic Netter art, updated and new illustrations, and modern imaging continue to bring medical concepts to life and make this timeless work an essential resource for students, clinicians, and educators.
1. Introductions to the First Edition - p. vii 2. Contributors - p. ix 3. Contributors to Second Edition - p. xi 4. Contents of Complete Volume 6—Musculoskeletal System: Three Part Set - p. xiii 5. 1. Embryology - p. 1 6. 2. Physiology - p. 23 7. Plates 2.1-2.2 Structural organization of skeletal muscle - p. 23 8. Plate 2.3 Intrinsic blood supply of skeletal muscle - p. 25 9. Plate 2.4 Composition and structure of myofilaments - p. 26 10. Plate 2.5 Muscle contraction and relaxation - p. 27 11. Plate 2.6 Biochemical mechanics of muscle contraction - p. 28 12. Plates 2.7-2.8 Sarcoplasmic reticulum and initiation of muscle contraction - p. 29 13. Plate 2.9 Motor unit - p. 31 14. Plate 2.10 Structure of neuromuscular junction - p. 32 15. Plate 2.11 Physiology of neuromuscular junction - p. 33 16. Plate 2.12 Pharmacology of neuromuscular transmission - p. 34 17. Plate 2.13 Physiology of muscle contraction - p. 35 18. Plate 2.14 Energy metabolism of muscle - p. 36 19. Plate 2.15 Muscle fiber types - p. 37 20. Plates 2.16-2.19 Growth plate - p. 38 21. Plate 2.20 Composition and structure of cartilage - p. 42 22. Plates 2.21-2.24 Composition and structure of bone - p. 43 23. Plate 2.25 Formation and composition of collagen - p. 47 24. Plate 2.26 Formation and composition of proteoglycan - p. 48 25. Plate 2.27 Structure and function of synovial membrane - p. 49 26. Plate 2.28 Histology of connective tissue - p. 50 27. Plates 2.29-2.30 Bone homeostasis - p. 51 28. Plates 2.31-2.32 Regulation of bone mass - p. 53 29. Plate 2.33 Normal calcium and phosphate metabolism - p. 55 30. Plate 2.34 Nutritional calcium deficiency - p. 57 31. Plate 2.35 Effects of disuse and stress (weight-bearing) on bone mass - p. 58 32. Plate 2.36 Musculoskeletal effects of weightlessness (space flight) - p. 59 33. Plates 2.37-2.39 Physical factors in bone remodeling - p. 60 34. Plates 2.40-2.41 Age-related changes in bone geometry - p. 63 35. 3. Metabolic diseases - p. 67 36. Plate 3.1 Parathyroid hormone - p. 67 37. Plates 3.2-3.3 Primary hyperparathyroidism - p. 68 38. Plate 3.4 Differential diagnosis of hypercalcemic states - p. 70 39. Plate 3.5 Hypoparathyroidism - p. 71 40. Plate 3.6 Clinical manifestations of chronic hypoparathyroidism - p. 73 41. Plate 3.7 Clinical manifestations of hypocalcemia - p. 74 42. Plate 3.8 Pseudohypoparathyroidism - p. 75 43. Plates 3.9-3.10 Mechanism of parathyroid hormone activity on end organ - p. 76 44. Plates 3.11-3.12 Clinical guide to parathyroid hormone assay - p. 78 45. Plates 3.13-3.23 Rickets, osteomalacia, and renal osteodystrophy - p. 80 46. Plate 3.24 Clinical guide to vitamin D measurement - p. 91 47. Plate 3.25 Hypophosphatasia - p. 92 48. Plates 3.26-3.29 Causes of osteoporosis - p. 93 49. Plates 3.30-3.32 Radiology of osteopenia - p. 97 50. Plate 3.33 Transiliac bone biopsy - p. 101 51. Plate 3.34 Treatment of complications of spinal osteoporosis - p. 101 52. Plates 3.35-3.37 Treatment of osteoporosis - p. 102 53. Plates 3.38-3.39 Osteogenesis imperfecta - p. 105 54. Plates 3.40-3.41 Marfan syndrome - p. 108 55. Plates 3.42-3.43 Ehlers-Danlos syndrome - p. 110 56. Plate 3.44 Osteopetrosis (Albers-Schönberg disease) - p. 112 57. Plates 3.45-3.47 Paget disease of bone - p. 113 58. Plate 3.48 Fibrodysplasia ossificans progressiva - p. 116 59. 4. Congenital and developmental disorders - p. 119 60. Plates 4.1-4.4 Dwarfism: Overview and achondroplasia - p. 119 61. Plate 4.5 Dwarfism: Hypochondroplasia - p. 123 62. Plate 4.6 Diastrophic dwarfism - p. 124 63. Plate 4.7 Dwarfism: Pseudoachondroplasia - p. 125 64. Plate 4.8 Dwarfism: Metaphyseal chondrodysplasia, mckusick type - p. 126 65. Plate 4.9 Dwarfism: Metaphyseal chondrodysplasia, schmid type - p. 127 66. Plate 4.10 Dwarfism: Chondrodysplasia punctata - p. 128 67. Plate 4.11 Dwarfism: Chondroectodermal dysplasia (Ellis–Van Creveld Syndrome), grebe chondrodysplasia, and acromesomelic dysplasia - p. 129 68. Plate 4.12 Dwarfism: Multiple epiphyseal dysplasia, fairbank type - p. 130 69. Plate 4.13 Dwarfism: Pycnodysostosis (pyknodysostosis) - p. 131 70. Plate 4.14 Dwarfism: Camptomelic (campomelic) dysplasia - p. 132 71. Plate 4.15 Dwarfism: Spondyloepiphyseal dysplasia tarda and spondyloepiphyseal dysplasia congenita - p. 133 72. Plate 4.16 Dwarfism: Spondylocostal dysostosis and Dyggve-Melchior-Clausen dysplasia - p. 134 73. Plate 4.17 Dwarfism: Kniest dysplasia - p. 135 74. Plate 4.18 Dwarfism: Mucopolysaccharidoses - p. 136 75. Plate 4.19 Dwarfism: Principles of treatment of skeletal dysplasias - p. 137 76. Plates 4.20-4.23 Neurofibromatosis - p. 138 77. Plate 4.24 Arthrogryposis multiplex congenita - p. 142 78. Plate 4.25 Fibrodysplasia ossificans progressiva and progressive diaphyseal dysplasia - p. 143 79. Plate 4.26 Osteopetrosis and osteopoikilosis - p. 144 80. Plate 4.27 Melorheostosis - p. 145 81. Plate 4.28 Congenital elevation of scapula, absence of clavicle, and pseudarthrosis of clavicle - p. 146 82. Plate 4.29 Madelung deformity - p. 147 83. Plate 4.30 Congenital bowing of the tibia - p. 148 84. Plate 4.31 Congenital pseudarthrosis of the tibia and dislocation of the knee - p. 149 85. Plates 4.32-4.36 Leg-length discrepancy - p. 150 86. Plates 4.37-4.50 Congenital limb malformation - p. 155 87. 5. Rheumatic diseases - p. 171 88. Plates 5.1-5.9 Rheumatic diseases - p. 171 89. Plates 5.10-5.12 Treatment of rheumatoid arthritis - p. 180 90. Plates 5.13-5.15 Synovial fluid examination - p. 183 91. Plates 5.16-5.21 Juvenile arthritis - p. 186 92. Plates 5.22-5.28 Osteoarthritis - p. 192 93. Plates 5.29-5.31 Ankylosing spondylitis - p. 199 94. Plates 5.32-5.33 Psoriatic arthritis - p. 202 95. Plate 5.34 Reactive arthritis - p. 204 96. Plate 5.35 Infectious arthritis - p. 206 97. Plate 5.36 Tuberculous arthritis - p. 206 98. Plate 5.37 Hemophilic arthritis - p. 207 99. Plate 5.38 Neuropathic joint disease - p. 208 100. Plates 5.39-5.40 Gout and gouty arthritis - p. 209 101. Plate 5.41 Calcium pyrophosphate deposition disease (pseudogout) - p. 211 102. Plate 5.42 Nonarticular rheumatism - p. 212 103. Plates 5.43-5.44 Polymyalgia rheumatica and giant cell arteritis - p. 213 104. Plate 5.45 Fibromyalgia - p. 215 105. Plates 5.46-5.48 Autoinflammatory syndromes - p. 216 106. Plates 5.49-5.51 Vasculitis - p. 219 107. Plate 5.52-5.54 Systemic lupus erythematosus - p. 222 108. Plate 5.55 Antiphospholipid syndrome - p. 225 109. Plates 5.56-5.58 Scleroderma - p. 227 110. Plates 5.59-5.60 Polymyositis and dermatomyositis - p. 230 111. Plate 5.61 Primary angiitis of the central nervous system - p. 232 112. Plates 5.62-5.63 Behçet syndrome - p. 234 113. 6. Tumors of musculoskeletal system - p. 237 114. 7. Injury to musculoskeletal system - p. 271 115. 8. Soft tissue infections - p. 299 116. 9. Fracture complications - p. 309 117. Selected References - p. 327 118. Index - p. 329
Offering a concise, highly visual approach to the basic science and clinical pathology of the musculoskeletal system, this updated volume in The Netter Collection of Medical Illustrations (the CIBA "Green Books") contains unparalleled didactic illustrations reflecting the latest medical knowledge. Revised by Drs. Joseph Iannotti, Richard Parker, Abby G. Abelson, Brendan M. Patterson, and other experts from the Cleveland Clinic, Biology and Systemic Diseases, Part 3 of Musculoskeletal System, Volume 6, integrates core concepts of anatomy, physiology, and other basic sciences with common clinical correlates across health, medical, and surgical disciplines. Classic Netter art, updated and new illustrations, and modern imaging continue to bring medical concepts to life and make this timeless work an essential resource for students, clinicians, and educators.
1. Introductions to the First Edition - p. vii 2. Contributors - p. ix 3. Contributors to Second Edition - p. xi 4. Contents of Complete Volume 6—Musculoskeletal System: Three Part Set - p. xiii 5. 1. Embryology - p. 1 6. 2. Physiology - p. 23 7. Plates 2.1-2.2 Structural organization of skeletal muscle - p. 23 8. Plate 2.3 Intrinsic blood supply of skeletal muscle - p. 25 9. Plate 2.4 Composition and structure of myofilaments - p. 26 10. Plate 2.5 Muscle contraction and relaxation - p. 27 11. Plate 2.6 Biochemical mechanics of muscle contraction - p. 28 12. Plates 2.7-2.8 Sarcoplasmic reticulum and initiation of muscle contraction - p. 29 13. Plate 2.9 Motor unit - p. 31 14. Plate 2.10 Structure of neuromuscular junction - p. 32 15. Plate 2.11 Physiology of neuromuscular junction - p. 33 16. Plate 2.12 Pharmacology of neuromuscular transmission - p. 34 17. Plate 2.13 Physiology of muscle contraction - p. 35 18. Plate 2.14 Energy metabolism of muscle - p. 36 19. Plate 2.15 Muscle fiber types - p. 37 20. Plates 2.16-2.19 Growth plate - p. 38 21. Plate 2.20 Composition and structure of cartilage - p. 42 22. Plates 2.21-2.24 Composition and structure of bone - p. 43 23. Plate 2.25 Formation and composition of collagen - p. 47 24. Plate 2.26 Formation and composition of proteoglycan - p. 48 25. Plate 2.27 Structure and function of synovial membrane - p. 49 26. Plate 2.28 Histology of connective tissue - p. 50 27. Plates 2.29-2.30 Bone homeostasis - p. 51 28. Plates 2.31-2.32 Regulation of bone mass - p. 53 29. Plate 2.33 Normal calcium and phosphate metabolism - p. 55 30. Plate 2.34 Nutritional calcium deficiency - p. 57 31. Plate 2.35 Effects of disuse and stress (weight-bearing) on bone mass - p. 58 32. Plate 2.36 Musculoskeletal effects of weightlessness (space flight) - p. 59 33. Plates 2.37-2.39 Physical factors in bone remodeling - p. 60 34. Plates 2.40-2.41 Age-related changes in bone geometry - p. 63 35. 3. Metabolic diseases - p. 67 36. Plate 3.1 Parathyroid hormone - p. 67 37. Plates 3.2-3.3 Primary hyperparathyroidism - p. 68 38. Plate 3.4 Differential diagnosis of hypercalcemic states - p. 70 39. Plate 3.5 Hypoparathyroidism - p. 71 40. Plate 3.6 Clinical manifestations of chronic hypoparathyroidism - p. 73 41. Plate 3.7 Clinical manifestations of hypocalcemia - p. 74 42. Plate 3.8 Pseudohypoparathyroidism - p. 75 43. Plates 3.9-3.10 Mechanism of parathyroid hormone activity on end organ - p. 76 44. Plates 3.11-3.12 Clinical guide to parathyroid hormone assay - p. 78 45. Plates 3.13-3.23 Rickets, osteomalacia, and renal osteodystrophy - p. 80 46. Plate 3.24 Clinical guide to vitamin D measurement - p. 91 47. Plate 3.25 Hypophosphatasia - p. 92 48. Plates 3.26-3.29 Causes of osteoporosis - p. 93 49. Plates 3.30-3.32 Radiology of osteopenia - p. 97 50. Plate 3.33 Transiliac bone biopsy - p. 101 51. Plate 3.34 Treatment of complications of spinal osteoporosis - p. 101 52. Plates 3.35-3.37 Treatment of osteoporosis - p. 102 53. Plates 3.38-3.39 Osteogenesis imperfecta - p. 105 54. Plates 3.40-3.41 Marfan syndrome - p. 108 55. Plates 3.42-3.43 Ehlers-Danlos syndrome - p. 110 56. Plate 3.44 Osteopetrosis (Albers-Schönberg disease) - p. 112 57. Plates 3.45-3.47 Paget disease of bone - p. 113 58. Plate 3.48 Fibrodysplasia ossificans progressiva - p. 116 59. 4. Congenital and developmental disorders - p. 119 60. Plates 4.1-4.4 Dwarfism: Overview and achondroplasia - p. 119 61. Plate 4.5 Dwarfism: Hypochondroplasia - p. 123 62. Plate 4.6 Diastrophic dwarfism - p. 124 63. Plate 4.7 Dwarfism: Pseudoachondroplasia - p. 125 64. Plate 4.8 Dwarfism: Metaphyseal chondrodysplasia, mckusick type - p. 126 65. Plate 4.9 Dwarfism: Metaphyseal chondrodysplasia, schmid type - p. 127 66. Plate 4.10 Dwarfism: Chondrodysplasia punctata - p. 128 67. Plate 4.11 Dwarfism: Chondroectodermal dysplasia (Ellis–Van Creveld Syndrome), grebe chondrodysplasia, and acromesomelic dysplasia - p. 129 68. Plate 4.12 Dwarfism: Multiple epiphyseal dysplasia, fairbank type - p. 130 69. Plate 4.13 Dwarfism: Pycnodysostosis (pyknodysostosis) - p. 131 70. Plate 4.14 Dwarfism: Camptomelic (campomelic) dysplasia - p. 132 71. Plate 4.15 Dwarfism: Spondyloepiphyseal dysplasia tarda and spondyloepiphyseal dysplasia congenita - p. 133 72. Plate 4.16 Dwarfism: Spondylocostal dysostosis and Dyggve-Melchior-Clausen dysplasia - p. 134 73. Plate 4.17 Dwarfism: Kniest dysplasia - p. 135 74. Plate 4.18 Dwarfism: Mucopolysaccharidoses - p. 136 75. Plate 4.19 Dwarfism: Principles of treatment of skeletal dysplasias - p. 137 76. Plates 4.20-4.23 Neurofibromatosis - p. 138 77. Plate 4.24 Arthrogryposis multiplex congenita - p. 142 78. Plate 4.25 Fibrodysplasia ossificans progressiva and progressive diaphyseal dysplasia - p. 143 79. Plate 4.26 Osteopetrosis and osteopoikilosis - p. 144 80. Plate 4.27 Melorheostosis - p. 145 81. Plate 4.28 Congenital elevation of scapula, absence of clavicle, and pseudarthrosis of clavicle - p. 146 82. Plate 4.29 Madelung deformity - p. 147 83. Plate 4.30 Congenital bowing of the tibia - p. 148 84. Plate 4.31 Congenital pseudarthrosis of the tibia and dislocation of the knee - p. 149 85. Plates 4.32-4.36 Leg-length discrepancy - p. 150 86. Plates 4.37-4.50 Congenital limb malformation - p. 155 87. 5. Rheumatic diseases - p. 171 88. Plates 5.1-5.9 Rheumatic diseases - p. 171 89. Plates 5.10-5.12 Treatment of rheumatoid arthritis - p. 180 90. Plates 5.13-5.15 Synovial fluid examination - p. 183 91. Plates 5.16-5.21 Juvenile arthritis - p. 186 92. Plates 5.22-5.28 Osteoarthritis - p. 192 93. Plates 5.29-5.31 Ankylosing spondylitis - p. 199 94. Plates 5.32-5.33 Psoriatic arthritis - p. 202 95. Plate 5.34 Reactive arthritis - p. 204 96. Plate 5.35 Infectious arthritis - p. 206 97. Plate 5.36 Tuberculous arthritis - p. 206 98. Plate 5.37 Hemophilic arthritis - p. 207 99. Plate 5.38 Neuropathic joint disease - p. 208 100. Plates 5.39-5.40 Gout and gouty arthritis - p. 209 101. Plate 5.41 Calcium pyrophosphate deposition disease (pseudogout) - p. 211 102. Plate 5.42 Nonarticular rheumatism - p. 212 103. Plates 5.43-5.44 Polymyalgia rheumatica and giant cell arteritis - p. 213 104. Plate 5.45 Fibromyalgia - p. 215 105. Plates 5.46-5.48 Autoinflammatory syndromes - p. 216 106. Plates 5.49-5.51 Vasculitis - p. 219 107. Plate 5.52-5.54 Systemic lupus erythematosus - p. 222 108. Plate 5.55 Antiphospholipid syndrome - p. 225 109. Plates 5.56-5.58 Scleroderma - p. 227 110. Plates 5.59-5.60 Polymyositis and dermatomyositis - p. 230 111. Plate 5.61 Primary angiitis of the central nervous system - p. 232 112. Plates 5.62-5.63 Behçet syndrome - p. 234 113. 6. Tumors of musculoskeletal system - p. 237 114. 7. Injury to musculoskeletal system - p. 271 115. 8. Soft tissue infections - p. 299 116. 9. Fracture complications - p. 309 117. Selected References - p. 327 118. Index - p. 329
