Translational Neuroimmunology: Multiple Sclerosis provides an update on bench to bedside studies on Multiple Sclerosis as an autoimmune disease. Divided into twelve chapters, the book begins with an in-depth introduction to the neuroimmunology and immunopathology of multiple sclerosis. Sections also provide content on genetics and epigenetics, the microbiome, diagnosis, and treatment of multiple sclerosis. Finally, various precision treatments are covered. All information is presented in an accessible, practical format, making this volume a valuable resource for immunologists, neurologists and researchers in translational biomedical research.
1. Chapter 1. Introduction to the neuroimmunology of multiple sclerosis - p. 1 2. Chapter 2. Immunopathology of multiple sclerosis - p. 11 3. Chapter 3. Biomarkers in multiple sclerosis - p. 28 4. Chapter 4. The neuroimmunology of fatigue in multiple sclerosis - p. 61 5. Chapter 5. Microbiome and multiple sclerosis - p. 73 6. Chapter 6. Associations and interactions with herpesviruses and parasites (helminths) in people with multiple sclerosis - p. 89 7. Chapter 7. Cytotoxic T lymphocytes in multiple sclerosis: New targets for treatment? - p. 105 8. Chapter 8. Targeting leukocytes in multiple sclerosis: Therapeutic perspectives - p. 129 9. Chapter 9. Sphingosine-1-phosphate, its receptors, and their role in multiple sclerosis - p. 145 10. Chapter 10. Innate and adaptive immunomodulation by Bruton’s tyrosine kinase (BTK) inhibitors: An emerging treatment for multiple sclerosis - p. 175 11. Chapter 11. Monoclonal antibodies in multiple sclerosis treatment - p. 201 12. Chapter 12. Immune-mediated cognition impairment in multiple sclerosis - p. 217 13. Chapter 13. Activation of complement: A potent biomarker in multiple sclerosis - p. 233 14. Index - p. 247
Translational Neuroimmunology: Multiple Sclerosis provides an update on bench to bedside studies on Multiple Sclerosis as an autoimmune disease. Divided into twelve chapters, the book begins with an in-depth introduction to the neuroimmunology and immunopathology of multiple sclerosis. Sections also provide content on genetics and epigenetics, the microbiome, diagnosis, and treatment of multiple sclerosis. Finally, various precision treatments are covered. All information is presented in an accessible, practical format, making this volume a valuable resource for immunologists, neurologists and researchers in translational biomedical research.
1. Chapter 1. Introduction to the neuroimmunology of multiple sclerosis - p. 1 2. Chapter 2. Immunopathology of multiple sclerosis - p. 11 3. Chapter 3. Biomarkers in multiple sclerosis - p. 28 4. Chapter 4. The neuroimmunology of fatigue in multiple sclerosis - p. 61 5. Chapter 5. Microbiome and multiple sclerosis - p. 73 6. Chapter 6. Associations and interactions with herpesviruses and parasites (helminths) in people with multiple sclerosis - p. 89 7. Chapter 7. Cytotoxic T lymphocytes in multiple sclerosis: New targets for treatment? - p. 105 8. Chapter 8. Targeting leukocytes in multiple sclerosis: Therapeutic perspectives - p. 129 9. Chapter 9. Sphingosine-1-phosphate, its receptors, and their role in multiple sclerosis - p. 145 10. Chapter 10. Innate and adaptive immunomodulation by Bruton’s tyrosine kinase (BTK) inhibitors: An emerging treatment for multiple sclerosis - p. 175 11. Chapter 11. Monoclonal antibodies in multiple sclerosis treatment - p. 201 12. Chapter 12. Immune-mediated cognition impairment in multiple sclerosis - p. 217 13. Chapter 13. Activation of complement: A potent biomarker in multiple sclerosis - p. 233 14. Index - p. 247
