Apply the latest scientific and clinical advances with Wall & Melzack's Textbook of Pain, 6th Edition. Drs. McMahon, Koltzenburg, Tracey, and Turk, along with more than 125 other leading authorities, present all of the latest knowledge about the genetics, neurophysiology, psychology, and assessment of every type of pain syndrome. They also provide practical guidance on the full range of today's pharmacologic, interventional, electrostimulative, physiotherapeutic, and psychological management options.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedication - p. iii 6. Contributors - p. iii 7. Foreword - p. iii 8. Preface - p. iii 9. Abbreviations and Acronyms - p. gxix 10. List of Illustrations - p. gxxvi 11. List of Tables - p. gxxvi 12. Section I: Neurobiology of Pain - p. gxxvi 13. Chapter 1: Peripheral Mechanisms of Cutaneous Nociception - p. gxxvi 14. Chapter 2: Molecular Biology of Sensory Transduction - p. g30 15. Chapter 3: Inflammatory Mediators and Modulators of Pain - p. g47 16. Chapter 4: Microglia: Critical Mediators of Pain Hypersensitivity after Peripheral Nerve Injury - p. g67 17. Chapter 5: Neuroanatomical Substrates of Spinal Nociception - p. g76 18. Chapter 6: Spinal Cord Plasticity and Pain - p. g93 19. Chapter 7: Representation of Pain in the Brain - p. g110 20. Chapter 8: Central Nervous System Mechanisms of Pain Modulation - p. g128 21. Chapter 9: Development of Pain Pathways and Mechanisms - p. g142 22. Chapter 10: Genetics of Pain - p. g155 23. Chapter 11: Animal Models of Pain - p. g169 24. Chapter 12: Ascending Projection Systems - p. g181 25. Chapter 13: Autonomic, Endocrine, and Immune Interactions in Acute and Chronic Pain - p. g197 26. Chapter 14: Itch - p. g210 27. Section II: Assessment and Psychology of Pain - p. g219 28. Chapter 15: Gender Differences in Pain and Its Relief - p. g219 29. Chapter 16: Epidemiology of Pain - p. g231 30. Chapter 17: Emotion, Motivation, and Pain - p. g247 31. Chapter 18: Cognitive and Learning Aspects - p. g255 32. Chapter 19: Psychiatric Pain-Associated Co-morbidities - p. g272 33. Chapter 20: Studies of Pain in Human Subjects - p. g282 34. Chapter 21: Pain Measurement in Adult Patients - p. g300 35. Chapter 22: Pain in Older Persons - p. g314 36. Chapter 23: Measurement and Assessment of Pediatric Pain - p. g319 37. Chapter 24: Assessment of Pain Beliefs, Coping, and Function - p. g327 38. Chapter 25: Hypnotic Analgesia - p. g338 39. Chapter 26: Pain, Opiates, and Addiction - p. g350 40. Chapter 27: Placebo Analgesia - p. g361 41. Section III: Pharmacology and Treatment of Pain - p. g373 42. Chapter 28: Spinal Pharmacology of Nociceptive Transmission - p. g373 43. Chapter 29: Methods of Therapeutic Trials - p. g401 44. Chapter 30: Opioids: Basic Mechanisms - p. g412 45. Chapter 31: Opioids: Clinical Use - p. g428 46. Chapter 32: Cyclooxygenase Inhibitors: Basic Aspects - p. g443 47. Chapter 33: Cyclooxygenase Inhibitors: Clinical Use - p. g454 48. Chapter 34: Antidepressant Analgesics - p. g464 49. Chapter 35: Mechanism of Action of Anticonvulsants as Analgesic Drugs - p. g490 50. Chapter 36: Anticonvulsants: Clinical - p. g499 51. Chapter 37: Local Anesthetic Blocks and Epidurals - p. g522 52. Chapter 38: Cannabinoids - p. g537 53. Chapter 39: Analgesic Drugs in Development - p. g551 54. Chapter 40: Neurosurgical Approaches to the Treatment of Pain - p. g562 55. Chapter 41: Spinal Cord and Brain Stimulation - p. g569 56. Chapter 42: The Cognitive-Behavioral Approach to Pain Management - p. g591 57. Chapter 43: A Critical Appraisal of Complementary and Alternative Medicine - p. g602 58. Section IV: Clinical States/Deep Somatic Tissue - p. g608 59. Chapter 44: Joint Pain: Basic Mechanisms - p. g608 60. Chapter 45: Basic Mechanisms of Muscle Pain - p. g619 61. Chapter 46: Postoperative Pain and Its Management - p. g628 62. Chapter 47: Osteoarthritis and Rheumatoid Arthritis - p. g644 63. Chapter 48: Fibromyalgia Syndrome and Myofascial Pain Syndrome - p. g657 64. Chapter 49: Low Back Pain - p. g682 65. Chapter 50: Non-specific Arm Pain - p. g690 66. Section V: Clinical States/Viscera - p. g702 67. Chapter 51: Visceral Pain: Basic Mechanisms - p. g702 68. Chapter 52: Thoracic Pain - p. g717 69. Chapter 53: A Clinical Perspective on Abdominal Pain - p. g732 70. Chapter 54: Genitourinary Pain - p. g757 71. Chapter 55: Obstetric Pain - p. g771 72. Section VI: Clinical States/Headache and Facial Pain - p. g792 73. Chapter 56: Trigeminal Mechanisms of Nociception - p. g792 74. Chapter 57: Acute and Chronic Orofacial and Dental Pain - p. g802 75. Chapter 58: Migraine and the Trigeminal Autonomic Cephalalgias - p. g814 76. Chapter 59: Tension-Type Headache - p. g831 77. Chapter 60: Pain in and around the Eye - p. g842 78. Section VII: Clinical States/Neuropathic Pain - p. g860 79. Chapter 61: Neuropathic Pain: Pathophysiological Response of Nerves to Injury - p. g860 80. Chapter 62: Animal Models of Experimental Neuropathic Pain - p. g888 81. Chapter 63: Central Consequences of Peripheral Nerve Damage - p. g901 82. Chapter 64: Phantom Limb - p. g914 83. Chapter 65: Painful Peripheral Neuropathies - p. g924 84. Chapter 66: Trigeminal and Glossopharyngeal Neuralgia - p. g951 85. Chapter 67: Complex Regional Pain Syndromes - p. g960 86. Chapter 68: Pain following Spinal Cord Injury - p. g977 87. Chapter 69: Central Pain - p. g989 88. Chapter 70: Pharmacological Therapy for Neuropathic Pain - p. g1002 89. Chapter 71: Surgery for Back and Neck Pain (Including Radiculopathies) - p. g1011 90. Section VIII: Clinical States/Cancer Pain - p. g1027 91. Chapter 72: Cancer Pain: Causes, Consequences, and Therapeutic Opportunities - p. g1027 92. Chapter 73: Cancer Pain Assessment and Syndromes - p. g1038 93. Chapter 74: Analgesic Therapy and Palliative Care in Children - p. g1060 94. Chapter 75: Cancer Pain: Treatment Overview - p. g1074 95. Chapter 76: Pain Control in the Care of the Dying - p. g1091 96. Index - p. g1099
Apply the latest scientific and clinical advances with Wall & Melzack's Textbook of Pain, 6th Edition. Drs. McMahon, Koltzenburg, Tracey, and Turk, along with more than 125 other leading authorities, present all of the latest knowledge about the genetics, neurophysiology, psychology, and assessment of every type of pain syndrome. They also provide practical guidance on the full range of today's pharmacologic, interventional, electrostimulative, physiotherapeutic, and psychological management options.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedication - p. iii 6. Contributors - p. iii 7. Foreword - p. iii 8. Preface - p. iii 9. Abbreviations and Acronyms - p. gxix 10. List of Illustrations - p. gxxvi 11. List of Tables - p. gxxvi 12. Section I: Neurobiology of Pain - p. gxxvi 13. Chapter 1: Peripheral Mechanisms of Cutaneous Nociception - p. gxxvi 14. Chapter 2: Molecular Biology of Sensory Transduction - p. g30 15. Chapter 3: Inflammatory Mediators and Modulators of Pain - p. g47 16. Chapter 4: Microglia: Critical Mediators of Pain Hypersensitivity after Peripheral Nerve Injury - p. g67 17. Chapter 5: Neuroanatomical Substrates of Spinal Nociception - p. g76 18. Chapter 6: Spinal Cord Plasticity and Pain - p. g93 19. Chapter 7: Representation of Pain in the Brain - p. g110 20. Chapter 8: Central Nervous System Mechanisms of Pain Modulation - p. g128 21. Chapter 9: Development of Pain Pathways and Mechanisms - p. g142 22. Chapter 10: Genetics of Pain - p. g155 23. Chapter 11: Animal Models of Pain - p. g169 24. Chapter 12: Ascending Projection Systems - p. g181 25. Chapter 13: Autonomic, Endocrine, and Immune Interactions in Acute and Chronic Pain - p. g197 26. Chapter 14: Itch - p. g210 27. Section II: Assessment and Psychology of Pain - p. g219 28. Chapter 15: Gender Differences in Pain and Its Relief - p. g219 29. Chapter 16: Epidemiology of Pain - p. g231 30. Chapter 17: Emotion, Motivation, and Pain - p. g247 31. Chapter 18: Cognitive and Learning Aspects - p. g255 32. Chapter 19: Psychiatric Pain-Associated Co-morbidities - p. g272 33. Chapter 20: Studies of Pain in Human Subjects - p. g282 34. Chapter 21: Pain Measurement in Adult Patients - p. g300 35. Chapter 22: Pain in Older Persons - p. g314 36. Chapter 23: Measurement and Assessment of Pediatric Pain - p. g319 37. Chapter 24: Assessment of Pain Beliefs, Coping, and Function - p. g327 38. Chapter 25: Hypnotic Analgesia - p. g338 39. Chapter 26: Pain, Opiates, and Addiction - p. g350 40. Chapter 27: Placebo Analgesia - p. g361 41. Section III: Pharmacology and Treatment of Pain - p. g373 42. Chapter 28: Spinal Pharmacology of Nociceptive Transmission - p. g373 43. Chapter 29: Methods of Therapeutic Trials - p. g401 44. Chapter 30: Opioids: Basic Mechanisms - p. g412 45. Chapter 31: Opioids: Clinical Use - p. g428 46. Chapter 32: Cyclooxygenase Inhibitors: Basic Aspects - p. g443 47. Chapter 33: Cyclooxygenase Inhibitors: Clinical Use - p. g454 48. Chapter 34: Antidepressant Analgesics - p. g464 49. Chapter 35: Mechanism of Action of Anticonvulsants as Analgesic Drugs - p. g490 50. Chapter 36: Anticonvulsants: Clinical - p. g499 51. Chapter 37: Local Anesthetic Blocks and Epidurals - p. g522 52. Chapter 38: Cannabinoids - p. g537 53. Chapter 39: Analgesic Drugs in Development - p. g551 54. Chapter 40: Neurosurgical Approaches to the Treatment of Pain - p. g562 55. Chapter 41: Spinal Cord and Brain Stimulation - p. g569 56. Chapter 42: The Cognitive-Behavioral Approach to Pain Management - p. g591 57. Chapter 43: A Critical Appraisal of Complementary and Alternative Medicine - p. g602 58. Section IV: Clinical States/Deep Somatic Tissue - p. g608 59. Chapter 44: Joint Pain: Basic Mechanisms - p. g608 60. Chapter 45: Basic Mechanisms of Muscle Pain - p. g619 61. Chapter 46: Postoperative Pain and Its Management - p. g628 62. Chapter 47: Osteoarthritis and Rheumatoid Arthritis - p. g644 63. Chapter 48: Fibromyalgia Syndrome and Myofascial Pain Syndrome - p. g657 64. Chapter 49: Low Back Pain - p. g682 65. Chapter 50: Non-specific Arm Pain - p. g690 66. Section V: Clinical States/Viscera - p. g702 67. Chapter 51: Visceral Pain: Basic Mechanisms - p. g702 68. Chapter 52: Thoracic Pain - p. g717 69. Chapter 53: A Clinical Perspective on Abdominal Pain - p. g732 70. Chapter 54: Genitourinary Pain - p. g757 71. Chapter 55: Obstetric Pain - p. g771 72. Section VI: Clinical States/Headache and Facial Pain - p. g792 73. Chapter 56: Trigeminal Mechanisms of Nociception - p. g792 74. Chapter 57: Acute and Chronic Orofacial and Dental Pain - p. g802 75. Chapter 58: Migraine and the Trigeminal Autonomic Cephalalgias - p. g814 76. Chapter 59: Tension-Type Headache - p. g831 77. Chapter 60: Pain in and around the Eye - p. g842 78. Section VII: Clinical States/Neuropathic Pain - p. g860 79. Chapter 61: Neuropathic Pain: Pathophysiological Response of Nerves to Injury - p. g860 80. Chapter 62: Animal Models of Experimental Neuropathic Pain - p. g888 81. Chapter 63: Central Consequences of Peripheral Nerve Damage - p. g901 82. Chapter 64: Phantom Limb - p. g914 83. Chapter 65: Painful Peripheral Neuropathies - p. g924 84. Chapter 66: Trigeminal and Glossopharyngeal Neuralgia - p. g951 85. Chapter 67: Complex Regional Pain Syndromes - p. g960 86. Chapter 68: Pain following Spinal Cord Injury - p. g977 87. Chapter 69: Central Pain - p. g989 88. Chapter 70: Pharmacological Therapy for Neuropathic Pain - p. g1002 89. Chapter 71: Surgery for Back and Neck Pain (Including Radiculopathies) - p. g1011 90. Section VIII: Clinical States/Cancer Pain - p. g1027 91. Chapter 72: Cancer Pain: Causes, Consequences, and Therapeutic Opportunities - p. g1027 92. Chapter 73: Cancer Pain Assessment and Syndromes - p. g1038 93. Chapter 74: Analgesic Therapy and Palliative Care in Children - p. g1060 94. Chapter 75: Cancer Pain: Treatment Overview - p. g1074 95. Chapter 76: Pain Control in the Care of the Dying - p. g1091 96. Index - p. g1099
