Xenobiotics in Chemical Carcinogenesis: Translational Aspects in Toxicology covers the translational toxicology of xenobiotics substances in carcinogenesis by explaining the toxicokinetic and toxicodynamic, toxicogenomic, biotransformation, and resistance mechanisms in the human body. The book begins with a historical review and link to future prospects for chemical carcinogenesis. It discusses major environmental xenobiotics and their risks in inducing cancer, along with content on toxic xenobiotics and their routes of exposure in humans, the role of xenobiotic metabolism in carcinogenesis, and the toxicokinetic and toxicodynamic of xenobiotics in cancer development.
Lastly, the book explores current achievements such as using toxicogenomics for predicting the carcinogenicity of xenobiotic substances and the challenges posed by carcinogenic xenobiotic substances when examining preventive methods, diagnosis, and the development of anticancer drugs for specific toxicants.
1. Xenobiotics in Chemical Carcinogenesis - p. Page i 2. Cover - p. Page i 3. Title page - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iii 6. Dedication - p. Page v 7. Contents - p. Page vii 8. Preface - p. Page vii 9. List of Illustrations - p. Page x 10. List of Tables - p. Page xi 11. Chapter 1 : Historical review and future prospective of chemical carcinogenesis - p. Page xi 12. Chapter 2 : Xenobiotic metabolism(s) in carcinogenesis - p. Page 15 13. Chapter 3 : Recalcitrant toxic xenobiotics and their routes of exposure to humans - p. Page 32 14. Chapter 4 : Incidences of crucial environmental xenobiotics for inducing cancers - p. Page 54 15. Chapter 5 : Toxicokinetics and toxicodynamics of xenobiotics in cancer development - p. Page 60 16. Chapter 6 : Mechanism of oxidative stress in carcinogenesis induced by xenobiotics - p. Page 78 17. Chapter 7 : Genotoxic and non-genotoxic activities of xenobiotics in carcinogenesis - p. Page 102 18. Chapter 8 : Modulation of the epigenome by xenobiotics in cancer - p. Page 122 19. Chapter 9 : Carcinogenic effects of nanomaterials with an emphasis on nanoplastics - p. Page 147 20. Chapter 10 : Endocrine disruptor activity of xenobiotics in carcinogenesis - p. Page 168 21. Chapter 11 : Environmental exposures as xenoestrogens (bisphenol A and phthalates) enhance risk for breast cancer - p. Page 192 22. Chapter 12 : Biotransformation of toxic xenobiotics by human gut microbiota - p. Page 210 23. Chapter 13 : Mechanism of resistance to toxic xenobiotics in humans - p. Page 237 24. Chapter 14 : Profiling the reactive metabolites of xenobiotics in cancer - p. Page 256 25. Chapter 15 : Toxicogenomics for the prediction of carcinogenicity of xenobiotic substances - p. Page 277 26. Index - p. Page 300
Xenobiotics in Chemical Carcinogenesis: Translational Aspects in Toxicology covers the translational toxicology of xenobiotics substances in carcinogenesis by explaining the toxicokinetic and toxicodynamic, toxicogenomic, biotransformation, and resistance mechanisms in the human body. The book begins with a historical review and link to future prospects for chemical carcinogenesis. It discusses major environmental xenobiotics and their risks in inducing cancer, along with content on toxic xenobiotics and their routes of exposure in humans, the role of xenobiotic metabolism in carcinogenesis, and the toxicokinetic and toxicodynamic of xenobiotics in cancer development.
Lastly, the book explores current achievements such as using toxicogenomics for predicting the carcinogenicity of xenobiotic substances and the challenges posed by carcinogenic xenobiotic substances when examining preventive methods, diagnosis, and the development of anticancer drugs for specific toxicants.
1. Xenobiotics in Chemical Carcinogenesis - p. Page i 2. Cover - p. Page i 3. Title page - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iii 6. Dedication - p. Page v 7. Contents - p. Page vii 8. Preface - p. Page vii 9. List of Illustrations - p. Page x 10. List of Tables - p. Page xi 11. Chapter 1 : Historical review and future prospective of chemical carcinogenesis - p. Page xi 12. Chapter 2 : Xenobiotic metabolism(s) in carcinogenesis - p. Page 15 13. Chapter 3 : Recalcitrant toxic xenobiotics and their routes of exposure to humans - p. Page 32 14. Chapter 4 : Incidences of crucial environmental xenobiotics for inducing cancers - p. Page 54 15. Chapter 5 : Toxicokinetics and toxicodynamics of xenobiotics in cancer development - p. Page 60 16. Chapter 6 : Mechanism of oxidative stress in carcinogenesis induced by xenobiotics - p. Page 78 17. Chapter 7 : Genotoxic and non-genotoxic activities of xenobiotics in carcinogenesis - p. Page 102 18. Chapter 8 : Modulation of the epigenome by xenobiotics in cancer - p. Page 122 19. Chapter 9 : Carcinogenic effects of nanomaterials with an emphasis on nanoplastics - p. Page 147 20. Chapter 10 : Endocrine disruptor activity of xenobiotics in carcinogenesis - p. Page 168 21. Chapter 11 : Environmental exposures as xenoestrogens (bisphenol A and phthalates) enhance risk for breast cancer - p. Page 192 22. Chapter 12 : Biotransformation of toxic xenobiotics by human gut microbiota - p. Page 210 23. Chapter 13 : Mechanism of resistance to toxic xenobiotics in humans - p. Page 237 24. Chapter 14 : Profiling the reactive metabolites of xenobiotics in cancer - p. Page 256 25. Chapter 15 : Toxicogenomics for the prediction of carcinogenicity of xenobiotic substances - p. Page 277 26. Index - p. Page 300
