Zipes and Jalife’s Cardiac Electrophysiology: From Cell to Bedside

1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Dedication - p. iii 6. Dedication - p. v 7. Contributors - p. vii 8. Preface - p. xx 9. Videos - p. xx 10. Part I. Structural and Molecular Bases of Ion Channel Function - p. xx 11. 1. Voltage-Gated Sodium Channels and Electrical Excitability of the Heart - p. 1 12. 2. Voltage-Gated Calcium Channels - p. 14 13. 3. Voltage-Regulated Potassium Channels - p. 31 14. 4. Molecular Regulation of Cardiac Inward Rectifier Potassium Channels - p. 41 15. 5. Mammalian Calcium Pumps in Health and Disease - p. 50 16. 6. Structural and Molecular Bases of Sarcoplasmic Reticulum Ion Channel Function - p. 63 17. 7. Organellar Ion Channels and Transporters - p. 70 18. 8. Gap Junctional Connexin43: Novel Insights from the New Millennium and Their Clinical Implications - p. 85 19. Part II. Biophysics of Cardiac Ion Channel Function - p. 102 20. 9. Computational Modeling and Simulation for Human Cardiac Electrophysiology: From Induced Pluripotent Stem Cell–Derived Cardiomyocytes to Adult Cardiomyocytes - p. 103 21. 10. Regulation of Cardiac Calcium Channels - p. 113 22. 11. Molecular Genetics of ATP-Sensitive Potassium Channels in Cardiovascular Diseases - p. 124 23. 12. Role of Enhancers in Transcriptional Regulation of Cardiac Electrical Activity - p. 138 24. 13. Functional Characterization of Ion Channel Gene Variants in Sudden Unexplained Natural Death - p. 143 25. 14. Stretch-Activated Potassium Channels in the Human Heart: Pathophysiologic and Clinical Significance - p. 155 26. 15. Connexins and Pannexins in Cardiovascular Disease - p. 168 27. 16. Excitation–Contraction Coupling - p. 178 28. Part III. Intermolecular Interactions and Cardiomyocyte Electrical Function - p. 187 29. 17. Ion Channel Trafficking in the Heart - p. 188 30. 18. Microdomain Interactions of Macromolecular Complexes and Regulation of the Sodium Channel NaV1.5 - p. 196 31. 19. Connecting Cardiac Excitation to the Atomic Interactions of Ion Channels - p. 210 32. 20. Macromolecular Complexes and Cardiac Potassium Channels - p. 218 33. 21. Reciprocity of Cardiac Sodium and Potassium Channels in the Control of Excitability and Arrhythmias - p. 228 34. 22. The Intercalated Disc: A Molecular Network That Integrates Electrical Coupling, Intercellular Adhesion, and Cell Excitability - p. 243 35. 23. Function and Dysfunction of Ion Channel Membrane Trafficking and Posttranslational Modification - p. 258 36. 24. Feedback Mechanisms for Cardiac-Specific microRNAs and cAMP Signaling in Electrical Remodeling - p. 266 37. Part IV. Cell Biology of Cardiac Impulse Initiation and Propagation - p. 275 38. 25. Coupled Oscillators and Sinoatrial Pacemaker Activity - p. 276 39. 26. Mapping of Cardiac Action Potentials in Zebrafish to Assess Genetic Variants - p. 291 40. 27. Cell-To-Cell Communication and Impulse Propagation - p. 302 41. 28. Mechanisms of Normal and Dysfunctional Sinoatrial Nodal Excitability and Propagation - p. 316 42. 29. Cell Biology of the Specialized Cardiac Conduction System - p. 330 43. Part V. Models of Cardiac Excitation - p. 343 44. 30. Computational Prediction of Drug-Induced Arrhythmias - p. 344 45. 31. Global Optimization Approaches to Generate Dynamically Robust Electrophysiologic Models - p. 351 46. 32. Calcium Signaling in Cardiomyocyte Models With Realistic Geometries - p. 362 47. 33. Theory of Rotors and Arrhythmias - p. 376 48. 34. Distinct ECG Phenotypes Identified in Hypertrophic Cardiomyopathy Using Machine Learning Associated With Arrhythmic Risk Markers - p. 387 49. 35. Computational Approaches for Accurate Rotor Localization in the Atria - p. 404 50. 36. Modeling the Aging Heart - p. 418 51. 37. Electromechanic Imaging of the Heart - p. 430 52. Part VI. Neural Control of Cardiac Electrical Activity - p. 443 53. 38. Innervation of the Sinoatrial Node - p. 444 54. 39. Autonomic and Oxidant Regulation of Cardiac Sodium Currents: Mechanisms and Consequences - p. 452 55. 40. Neural Activity and Atrial Tachyarrhythmias - p. 461 56. 41. Sympathetic Modulation of Cardiac Electrophysiology - p. 473 57. 42. Role of the Autonomic Nervous System in Atrial Fibrillation - p. 481 58. Part VII. Arrhythmia Mechanisms - p. 488 59. 43. Rotational and Focal Sources of Atrial Fibrillation: Scientific Rationale and Comparative Clinical Mapping - p. 489 60. 44. Noninvasive Frequency-Phase Mapping of Atrial Fibrillation - p. 505 61. 45. Mechanistic Approaches for Persistent Atrial Fibrillation Ablation - p. 513 62. 46. Mechanisms of Human Ventricular Tachycardia and Human Ventricular Fibrillation - p. 529 63. 47. Genetics of Atrial Fibrillation - p. 546 64. Part VIII. Molecular Genetics and Pharmacogenomics - p. 553 65. 48. Mechanisms in Genetic Sodium Channel Diseases - p. 554 66. 49. Genetic, Ionic, and Cellular Mechanisms Underlying the J Wave Syndromes - p. 565 67. 50. Inheritable Potassium Channel Diseases - p. 583 68. 51. Inheritable Phenotypes Associated With Altered Intracellular Calcium Regulation - p. 594 69. Part IX. Pharmacologic, Genetic, and Cell Therapy of Ion Channel Dysfunction - p. 603 70. 52. Dominant Frequency as a Tool for Personalized Monitoring of Atrial Fibrillation Progression and Upstream Therapy - p. 604 71. 53. Pharmacogenomics of Cardiac Arrhythmias - p. 615 72. 54. Deep Phenotyping: Adding New Tools to Understand Disease - p. 622 73. 55. Gene Therapy for Atrial Fibrillation - p. 631 74. Part X. Cell Biology and Electrophysiology of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes - p. 644 75. 56. Cardiac Remodeling and Regeneration - p. 645 76. 57. High-Throughput Optical Mapping of Two-Dimensional hiPSC-CM Platforms for Drug Discovery and Cardiotoxicity Testing - p. 654 77. 58. Functional Cardiac Fibroblasts Derived From Human Pluripotent Stem Cells via Second Heart Field Progenitors - p. 671 78. 59. Challenges of Human iPSC-CM Technology: Increasingly Complex Approaches Improve Cell Maturation and Relevance to Modeling Human Cardiac Disease - p. 680 79. Part XI. Diagnostic Evaluation - p. 692 80. 60. Assessment of the Patient With a Cardiac Arrhythmia - p. 693 81. 61. Differential Diagnosis of Narrow and Wide Complex Tachycardias - p. 700 82. 62. Electrocardiographic Monitoring: Short- and Long-Term Recording - p. 708 83. 63. Personal Cardiac Monitoring - p. 716 84. 64. Computed Tomography for Electrophysiology - p. 728 85. 65. Magnetic Resonance Imaging for Electrophysiology - p. 744 86. 66. Intracardiac Echocardiography for Electrophysiology - p. 756 87. 67. Autonomic Nervous System Assessment for Syncope and Arrhythmia Risk - p. 764 88. 68. Noninvasive Electrocardiographic Imaging of Arrhythmogenic Substrates and Ventricular Arrhythmias - p. 773 89. 69. Genetic Testing - p. 786 90. Part XII. Supraventricular Arrhythmias: Diagnosis and Therapy - p. 791 91. 70. Supraventricular Tachycardias: Diagnostic Maneuvers in the Electrophysiology Laboratory - p. 792 92. 71. Atrial Tachycardia - p. 806 93. 72. Atrioventricular Nodal Reentrant Tachycardia - p. 829 94. 73. Junctional Tachycardia - p. 853 95. 74. Preexcitation, Atrioventricular Reentry, Variants - p. 861 96. 75. Atrial Fibrillation: Mechanisms, Clinical Features, and Management - p. 876 97. 76. Ablation for Atrial Fibrillation - p. 891 98. 77. Left Atrial Appendage Management: Anatomy, Physiology, and Role in Atrial Fibrillation–Related Stroke - p. 902 99. 78. Typical and Atypical Atrial Flutter: Mapping and Ablation - p. 911 100. Part XIII. Ventricular Arrhythmias - p. 924 101. 79. Sudden Cardiac Death in Adults - p. 925 102. 80. Premature Ventricular Complexes - p. 938 103. 81. Outflow Tract Ventricular Tachyarrhythmias: Mechanisms, Clinical Features, and Management - p. 947 104. 82. Premature Ventricular Contraction Ablation With Anatomic Guidance: Papillary Muscles, Moderator Band, and Valve Annulus Sites - p. 960 105. 83. Fascicular Ventricular Arrhythmias - p. 970 106. 84. Bundle Branch Reentry Tachycardia - p. 977 107. 85. Ischemic Heart Disease - p. 992 108. 86. Ablation of Postmyocardial Infarction Ventricular Tachycardia - p. 1001 109. 87. Ventricular Tachycardia in Patients With Dilated Cardiomyopathy - p. 1014 110. 88. Lamin A/C, Noncompaction, and Other Genetic Cardiomyopathies With Ventricular Arrhythmias - p. 1028 111. 89. Ventricular Tachyarrhythmias in Hypertrophic Cardiomyopathy: Sudden Death, Risk Stratification, and Prevention With Implantable Defibrillators - p. 1038 112. 90. Ventricular Tachycardias in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy - p. 1050 113. 91. Catecholaminergic Polymorphic Ventricular Tachycardia - p. 1061 114. 92. Arrhythmias and Conduction Disturbances in Noncompaction Cardiomyopathy - p. 1073 115. 93. Ventricular Arrhythmias in Takotsubo Cardiomyopathy - p. 1083 116. 94. Mitral Valve Prolapse, Ventricular Arrhythmias, and Sudden Death - p. 1089 117. 95. Brugada Syndrome - p. 1100 118. 96. Long and Short QT Syndromes - p. 1111 119. 97. Andersen-Tawil Syndrome - p. 1129 120. 98. Timothy Syndrome - p. 1136 121. 99. J Wave Syndromes - p. 1146 122. 100. Idiopathic and Short-Coupled Ventricular Fibrillation - p. 1157 123. 101. Mapping and Ablation of Ventricular Fibrillation - p. 1166 124. 102. Drug-Induced Ventricular Arrhythmias - p. 1178 125. Part XIV. Syncope and Bradyarrhythmias - p. 1188 126. 103. Syncope - p. 1189 127. 104. Sinus Node Abnormalities - p. 1197 128. 105. Postural Orthostatic Tachycardia Syndrome - p. 1203 129. 106. Atrioventricular Block - p. 1209 130. Part XV. Arrhythmias in Special Populations - p. 1217 131. 107. Sex Differences in Arrhythmias - p. 1218 132. 108. Sudden Cardiac Deaths in Athletes, Including Commotio Cordis - p. 1226 133. 109. Cardiac Sarcoidosis - p. 1240 134. 110. Sleep-Disordered Breathing and Arrhythmias - p. 1248 135. 111. Ventricular Assist Devices and Cardiac Transplant Recipients - p. 1257 136. 112. Arrhythmia in Neurologic Disease - p. 1269 137. 113. Cancer Therapy–Related Arrhythmias - p. 1286 138. Part XVI. Congenital Heart Disease and Pediatrics - p. 1295 139. 114. Arrhythmias in the Pediatric Population - p. 1296 140. 115. Supraventricular Tachycardias in Congenital Heart Disease - p. 1314 141. 116. Ventricular Arrhythmias in Congenital Heart Disease - p. 1330 142. Part XVII. Pharmacologic Therapy - p. 1346 143. 117. Antiarrhythmic Drugs - p. 1347 144. 118. Impact of Nontraditional Antiarrhythmic Drugs on Sudden Cardiac Death - p. 1362 145. 119. Anticoagulation for Thromboembolic Prophylaxis - p. 1371 146. Part XVIII. Devices for Arrhythmia Management - p. 1382 147. 120. Implantable Pacemakers - p. 1383 148. 121. Implantable Cardioverter-Defibrillators: Technical Aspects - p. 1395 149. 122. Transvenous Implantable Cardioverter-Defibrillator: Clinical Aspects - p. 1409 150. 123. Subcutaneous Implantable Cardioverter-Defibrillators - p. 1427 151. 124. Wearable Defibrillators - p. 1438 152. 125. Cardiac Resynchronization - p. 1445 153. 126. Management of Implanted Device Infections - p. 1462 154. Part XIX. Catheter and Surgical Mapping and Ablation - p. 1470 155. 127. Electrogram Recording and Signal Processing - p. 1471 156. 128. Electroanatomic Mapping for Arrhythmias - p. 1486 157. 129. Mapping Scar-Related Arrhythmias - p. 1503 158. 130. Radiofrequency Ablation - p. 1516 159. 131. Cryoablation and Other Radiofrequency Alternatives - p. 1531 160. 132. Transvascular Ethanol Ablation - p. 1543 161. 133. Cardiac Radioablation - p. 1557 162. 134. Epicardial Approach in Electrophysiology - p. 1566 163. 135. Surgery for Atrial Fibrillation and Other Supraventricular Tachycardias - p. 1581 164. 136. Surgery for Ventricular Arrhythmias - p. 1598 165. 137. Neuromodulation for the Treatment of Arrhythmias - p. 1609 166. Part XX. Drug Discovery for Cardiac Arrhythmias - p. 1620 167. 138. Drug Discovery for Myocardial Diseases and Cardiac Arrhythmias Using Zebrafish - p. 1621 168. Index - p. 1631