Fully updated from cover to cover, Zipes and Jalife’s Cardiac Electrophysiology: From Cell to Bedside, 8th Edition, provides the comprehensive, multidisciplinary coverage you need—from new knowledge in basic science to the latest clinical advances in the field. Drs. José Jalife and William Gregory Stevenson lead a team of global experts who provide cutting-edge content and step-by-step instructions for all aspects of cardiac electrophysiology.
Packs each chapter with the latest information necessary for optimal basic research as well as patient care.
Covers new technologies such as CRISPR, protein research, improved cardiac imaging, optical mapping, and wearable devices.
Contains significant updates in the areas of molecular biology and genetics, iPSCs (induced pluripotent stem cells), embryonic stem cells, precision medicine, antiarrhythmic drug therapy, cardiac mapping with advanced techniques, and ablation technologies including stereotactic radioablation.
Includes 47 new standalone chapters that are organized into discrete topics for improved access.
Discusses extensive recent progress in the understanding, diagnosis, and management of arrhythmias, including new clinical insights on atrial fibrillation and stroke prevention, new advances in the understanding of ventricular arrythmias in genetic disease, and advances in implantable devises and infection management.
Features 1,600 high-quality photographs, anatomic and radiographic images, electrocardiograms, tables, algorithms, and more., with additional figures, tables, and videos online.
Recipient of a 2018 Highly Commended award from the British Medical Association.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedication - p. iii 6. Dedication - p. iii 7. Contributors - p. iii 8. Preface - p. iii 9. List of Illustrations - p. iii 10. List of Tables - p. iii 11. Part I: Structural and Molecular Bases of Ion Channel Function - p. iii 12. Chapter 1: Voltage-Gated Sodium Channels and Electrical Excitability of the Heart - p. iii 13. Chapter 2: Voltage-Gated Calcium Channels - p. g11 14. Chapter 3: Voltage-Regulated Potassium Channels - p. g25 15. Chapter 4: Molecular Regulation of Cardiac Inward Rectifier Potassium Channels - p. g39 16. Chapter 5: Mammalian Calcium Pumps in Health and Disease - p. g47 17. Chapter 6: Structural and Molecular Bases of Sarcoplasmic Reticulum Ion Channel Function - p. g60 18. Chapter 7: Organellar Ion Channels and Transporters - p. g68 19. Chapter 8: Gap Junctional Connexin43: Novel Insights from the New Millennium and Their Clinical Implications - p. g82 20. Part II: Biophysics of Cardiac Ion Channel Function - p. g96 21. Chapter 9: Computational Modeling and Simulation for Human Cardiac Electrophysiology: From Induced Pluripotent Stem Cell–Derived Cardiomyocytes to Adult Cardiomyocytes - p. g96 22. Chapter 10: Regulation of Cardiac Calcium Channels - p. g109 23. Chapter 11: Molecular Genetics of ATP-Sensitive Potassium Channels in Cardiovascular Diseases - p. g120 24. Chapter 12: Role of Enhancers in Transcriptional Regulation of Cardiac Electrical Activity - p. g133 25. Chapter 13: Functional Characterization of Ion Channel Gene Variants in Sudden Unexplained Natural Death - p. g141 26. Chapter 14: Stretch-Activated Potassium Channels in the Human Heart: Pathophysiologic and Clinical Significance - p. g152 27. Chapter 15: Connexins and Pannexins in Cardiovascular Disease - p. g164 28. Chapter 16: Excitation–Contraction Coupling - p. g174 29. Part III: Intermolecular Interactions and Cardiomyocyte Electrical Function - p. g186 30. Chapter 17: Ion Channel Trafficking in the Heart - p. g186 31. Chapter 18: Microdomain Interactions of Macromolecular Complexes and Regulation of the Sodium Channel NaV1.5 - p. g193 32. Chapter 19: Connecting Cardiac Excitation to the Atomic Interactions of Ion Channels - p. g206 33. Chapter 20: Macromolecular Complexes and Cardiac Potassium Channels - p. g216 34. Chapter 21: Reciprocity of Cardiac Sodium and Potassium Channels in the Control of Excitability and Arrhythmias - p. g225 35. Chapter 22: The Intercalated Disc: A Molecular Network That Integrates Electrical Coupling, Intercellular Adhesion, and Cell Excitability - p. g240 36. Chapter 23: Function and Dysfunction of Ion Channel Membrane Trafficking and Posttranslational Modification - p. g253 37. Chapter 24: Feedback Mechanisms for Cardiac-Specific microRNAs and cAMP Signaling in Electrical Remodeling - p. g263 38. Part IV: Cell Biology of Cardiac Impulse Initiation and Propagation - p. g272 39. Chapter 25: Coupled Oscillators and Sinoatrial Pacemaker Activity - p. g272 40. Chapter 26: Mapping of Cardiac Action Potentials in Zebrafish to Assess Genetic Variants - p. g287 41. Chapter 27: Cell-To-Cell Communication and Impulse Propagation - p. g300 42. Chapter 28: Mechanisms of Normal and Dysfunctional Sinoatrial Nodal Excitability and Propagation - p. g313 43. Chapter 29: Cell Biology of the Specialized Cardiac Conduction System - p. g328 44. Part V: Models of Cardiac Excitation - p. g340 45. Chapter 30: Computational Prediction of Drug-Induced Arrhythmias - p. g340 46. Chapter 31: Global Optimization Approaches to Generate Dynamically Robust Electrophysiologic Models - p. g349 47. Chapter 32: Calcium Signaling in Cardiomyocyte Models With Realistic Geometries - p. g360 48. Chapter 33: Theory of Rotors and Arrhythmias - p. g373 49. Chapter 34: Distinct ECG Phenotypes Identified in Hypertrophic Cardiomyopathy Using Machine Learning Associated With Arrhythmic Risk Markers - p. g385 50. Chapter 35: Computational Approaches for Accurate Rotor Localization in the Atria - p. g401 51. Chapter 36: Modeling the Aging Heart - p. g415 52. Chapter 37: Electromechanic Imaging of the Heart - p. g426 53. Part VI: Neural Control of Cardiac Electrical Activity - p. g442 54. Chapter 38: Innervation of the Sinoatrial Node - p. g442 55. Chapter 39: Autonomic and Oxidant Regulation of Cardiac Sodium Currents Mechanisms and Consequences - p. g450 56. Chapter 40: Neural Activity and Atrial Tachyarrhythmias - p. g457 57. Chapter 41: Sympathetic Modulation of Cardiac Electrophysiology - p. g470 58. Chapter 42: Role of the Autonomic Nervous System in Atrial Fibrillation - p. g479 59. Part VII: Arrhythmia Mechanisms - p. g487 60. Chapter 43: Rotational and Focal Sources of Atrial Fibrillation: Scientific Rationale and Comparative Clinical Mapping - p. g487 61. Chapter 44: Noninvasive Frequency-Phase Mapping of Atrial Fibrillation - p. g501 62. Chapter 45: Mechanistic Approaches for Persistent Atrial Fibrillation Ablation - p. g511 63. Chapter 46: Mechanisms of Human Ventricular Tachycardia and Human Ventricular Fibrillation - p. g526 64. Chapter 47: Genetics of Atrial Fibrillation - p. g541 65. Part VIII: Molecular Genetics and Pharmacogenomics - p. g550 66. Chapter 48: Mechanisms in Genetic Sodium Channel Diseases - p. g550 67. Chapter 49: Genetic, Ionic, and Cellular Mechanisms Underlying the J Wave Syndromes - p. g561 68. Chapter 50: Inheritable Potassium Channel Diseases - p. g576 69. Chapter 51: Inheritable Phenotypes Associated With Altered Intracellular Calcium Regulation - p. g591 70. Part IX: Pharmacologic, Genetic, and Cell Therapy of Ion Channel Dysfunction - p. g601 71. Chapter 52: Dominant Frequency as a Tool for Personalized Monitoring of Atrial Fibrillation Progression and Upstream Therapy - p. g601 72. Chapter 53: Pharmacogenomics of Cardiac Arrhythmias - p. g611 73. Chapter 54: Deep Phenotyping: Adding New Tools to Understand Disease - p. g620 74. Chapter 55: Gene Therapy for Atrial Fibrillation - p. g629 75. Part X: Cell Biology and Electrophysiology of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes - p. g640 76. Chapter 56: Cardiac Remodeling and Regeneration - p. g640 77. Chapter 57: High-Throughput Optical Mapping of Two-Dimensional hiPSC-CM Platforms for Drug Discovery and Cardiotoxicity Testing - p. g650 78. Chapter 58: Functional Cardiac Fibroblasts Derived From Human Pluripotent Stem Cells via Second Heart Field Progenitors - p. g666 79. Chapter 59: Challenges of Human iPSC-CM Technology: Increasingly Complex Approaches Improve Cell Maturation and Relevance to Modeling Human Cardiac Disease - p. g677 80. Part XI: Diagnostic Evaluation - p. g689 81. Chapter 60: Assessment of the Patient With a Cardiac Arrhythmia - p. g689 82. Chapter 61: Differential Diagnosis of Narrow and Wide Complex Tachycardias - p. g698 83. Chapter 62: Electrocardiographic Monitoring: Short- and Long-Term Recording - p. g706 84. Chapter 63: Personal Cardiac Monitoring - p. g714 85. Chapter 64: Computed Tomography for Electrophysiology - p. g725 86. Chapter 65: Magnetic Resonance Imaging for Electrophysiology - p. g741 87. Chapter 66: Intracardiac Echocardiography for Electrophysiology - p. g752 88. Chapter 67: Autonomic Nervous System Assessment for Syncope and Arrhythmia Risk - p. g762 89. Chapter 68: Noninvasive Electrocardiographic Imaging of Arrhythmogenic Substrates and Ventricular Arrhythmias - p. g771 90. Chapter 69: Genetic Testing - p. g785 91. Part XII: Supraventricular Arrhythmias: Diagnosis and Therapy - p. g791 92. Chapter 70: Supraventricular Tachycardias: Diagnostic Maneuvers in the Electrophysiology Laboratory - p. g791 93. Chapter 71: Atrial Tachycardia - p. g804 94. Chapter 72: Atrioventricular Nodal Reentrant Tachycardia - p. g825 95. Chapter 73: Junctional Tachycardia - p. g852 96. Chapter 74: Preexcitation, Atrioventricular Reentry, Variants - p. g860 97. Chapter 75: Atrial Fibrillation: Mechanisms, Clinical Features, and Management - p. g874 98. Chapter 76: Ablation for Atrial Fibrillation - p. g886 99. Chapter 77: Left Atrial Appendage Management: Anatomy, Physiology, and Role in Atrial Fibrillation–Related Stroke - p. g899 100. Chapter 78: Typical and Atypical Atrial Flutter: Mapping and Ablation - p. g907 101. Part XIII: Ventricular Arrhythmias - p. g921 102. Chapter 79: Sudden Cardiac Death in Adults - p. g921 103. Chapter 80: Premature Ventricular Complexes - p. g936 104. Chapter 81: Outflow Tract Ventricular Tachyarrhythmias: Mechanisms, Clinical Features, and Management - p. g944 105. Chapter 82: Premature Ventricular Contraction Ablation With Anatomic Guidance: Papillary Muscles, Moderator Band, and Valve Annulus Sites - p. g956 106. Chapter 83: Fascicular Ventricular Arrhythmias - p. g968 107. Chapter 84: Bundle Branch Reentry Tachycardia - p. g975 108. Chapter 85: Ischemic Heart Disease - p. g988.e1 109. Chapter 86: Ablation of Postmyocardial Infarction Ventricular Tachycardia - p. g999 110. Chapter 87: Ventricular Tachycardia in Patients With Dilated Cardiomyopathy - p. g1011 111. Chapter 88: Lamin A/C, Noncompaction, and Other Genetic Cardiomyopathies With Ventricular Arrhythmias - p. g1024 112. Chapter 89: Ventricular Tachyarrhythmias in Hypertrophic Cardiomyopathy: Sudden Death, Risk Stratification, and Prevention With Implantable Defibrillators - p. g1035 113. Chapter 90: Ventricular Tachycardias in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy - p. g1048 114. Chapter 91: Catecholaminergic Polymorphic Ventricular Tachycardia - p. g1059 115. Chapter 92: Arrhythmias and Conduction Disturbances in Noncompaction Cardiomyopathy - p. g1070 116. Chapter 93: Ventricular Arrhythmias in Takotsubo Cardiomyopathy - p. g1081 117. Chapter 94: Mitral Valve Prolapse, Ventricular Arrhythmias, and Sudden Death - p. g1087 118. Chapter 95: Brugada Syndrome - p. g1097 119. Chapter 96: Long and Short QT Syndromes - p. g1108 120. Chapter 97: Andersen-Tawil Syndrome - p. g1125 121. Chapter 98: Timothy Syndrome - p. g1134 122. Chapter 99: J Wave Syndromes - p. g1143 123. Chapter 100: Idiopathic and Short-Coupled Ventricular Fibrillation - p. g1155 124. Chapter 101: Mapping and Ablation of Ventricular Fibrillation - p. g1163 125. Chapter 102: Drug-Induced Ventricular Arrhythmias - p. g1174 126. Part XIV: Syncope and Bradyarrhythmias - p. g1187 127. Chapter 103: Syncope - p. g1187 128. Chapter 104: Sinus Node Abnormalities - p. g1195 129. Chapter 105: Postural Orthostatic Tachycardia Syndrome - p. g1201 130. Chapter 106: Atrioventricular Block - p. g1208 131. Part XV: Arrhythmias in Special Populations - p. g1216 132. Chapter 107: Sex Differences in Arrhythmias - p. g1216 133. Chapter 108: Sudden Cardiac Deaths in Athletes, Including Commotio Cordis - p. g1224 134. Chapter 109: Cardiac Sarcoidosis - p. g1235 135. Chapter 110: Sleep-Disordered Breathing and Arrhythmias - p. g1246 136. Chapter 111: Ventricular Assist Devices and Cardiac Transplant Recipients - p. g1255 137. Chapter 112: Arrhythmia in Neurologic Disease - p. g1264 138. Chapter 113: Cancer Therapy–Related Arrhythmias - p. g1278 139. Part XVI: Congenital Heart Disease and Pediatrics - p. g1292 140. Chapter 114: Arrhythmias in the Pediatric Population - p. g1292 141. Chapter 115: Supraventricular Tachycardias in Congenital Heart Disease - p. g1310 142. Chapter 116: Ventricular Arrhythmias in Congenital Heart Disease - p. g1327 143. Part XVII: Pharmacologic Therapy - p. g1344 144. Chapter 117: Antiarrhythmic Drugs - p. g1344 145. Chapter 118: Impact of Nontraditional Antiarrhythmic Drugs on Sudden Cardiac Death - p. g1359 146. Chapter 119: Anticoagulation for Thromboembolic Prophylaxis - p. g1368 147. Part XVIII: Devices for Arrhythmia Management - p. g1380 148. Chapter 120: Implantable Pacemakers - p. g1380 149. Chapter 121: Implantable Cardioverter-Defibrillators: Technical Aspects - p. g1393 150. Chapter 122: Transvenous Implantable Cardioverter-Defibrillator: Clinical Aspects - p. g1408 151. Chapter 123: Subcutaneous Implantable Cardioverter-Defibrillators - p. g1425 152. Chapter 124: Wearable Defibrillators - p. g1435 153. Chapter 125: Cardiac Resynchronization - p. g1444 154. Chapter 126: Management of Implanted Device Infections - p. g1457 155. Part XIX: Catheter and Surgical Mapping and Ablation - p. g1468 156. Chapter 127: Electrogram Recording and Signal Processing - p. g1468 157. Chapter 128: Electroanatomic Mapping for Arrhythmias - p. g1484 158. Chapter 129: Mapping Scar-Related Arrhythmias - p. g1502 159. Chapter 130: Radiofrequency Ablation - p. g1510 160. Chapter 131: Cryoablation and Other Radiofrequency Alternatives - p. g1527 161. Chapter 132: Transvascular Ethanol Ablation - p. g1539 162. Chapter 133: Cardiac Radioablation - p. g1554 163. Chapter 134: Epicardial Approach in Electrophysiology - p. g1563 164. Chapter 135: Surgery for Atrial Fibrillation and Other Supraventricular Tachycardias - p. g1578 165. Chapter 136: Surgery for Ventricular Arrhythmias - p. g1593 166. Chapter 137: Neuromodulation for the Treatment of Arrhythmias - p. g1607 167. Part XX: Drug Discovery for Cardiac Arrhythmias - p. g1617 168. Chapter 138: Drug Discovery for Myocardial Diseases and Cardiac Arrhythmias Using Zebrafish - p. g1617 169. Index - p. g1628
Fully updated from cover to cover, Zipes and Jalife’s Cardiac Electrophysiology: From Cell to Bedside, 8th Edition, provides the comprehensive, multidisciplinary coverage you need—from new knowledge in basic science to the latest clinical advances in the field. Drs. José Jalife and William Gregory Stevenson lead a team of global experts who provide cutting-edge content and step-by-step instructions for all aspects of cardiac electrophysiology.
Packs each chapter with the latest information necessary for optimal basic research as well as patient care.
Covers new technologies such as CRISPR, protein research, improved cardiac imaging, optical mapping, and wearable devices.
Contains significant updates in the areas of molecular biology and genetics, iPSCs (induced pluripotent stem cells), embryonic stem cells, precision medicine, antiarrhythmic drug therapy, cardiac mapping with advanced techniques, and ablation technologies including stereotactic radioablation.
Includes 47 new standalone chapters that are organized into discrete topics for improved access.
Discusses extensive recent progress in the understanding, diagnosis, and management of arrhythmias, including new clinical insights on atrial fibrillation and stroke prevention, new advances in the understanding of ventricular arrythmias in genetic disease, and advances in implantable devises and infection management.
Features 1,600 high-quality photographs, anatomic and radiographic images, electrocardiograms, tables, algorithms, and more., with additional figures, tables, and videos online.
Recipient of a 2018 Highly Commended award from the British Medical Association.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedication - p. iii 6. Dedication - p. iii 7. Contributors - p. iii 8. Preface - p. iii 9. List of Illustrations - p. iii 10. List of Tables - p. iii 11. Part I: Structural and Molecular Bases of Ion Channel Function - p. iii 12. Chapter 1: Voltage-Gated Sodium Channels and Electrical Excitability of the Heart - p. iii 13. Chapter 2: Voltage-Gated Calcium Channels - p. g11 14. Chapter 3: Voltage-Regulated Potassium Channels - p. g25 15. Chapter 4: Molecular Regulation of Cardiac Inward Rectifier Potassium Channels - p. g39 16. Chapter 5: Mammalian Calcium Pumps in Health and Disease - p. g47 17. Chapter 6: Structural and Molecular Bases of Sarcoplasmic Reticulum Ion Channel Function - p. g60 18. Chapter 7: Organellar Ion Channels and Transporters - p. g68 19. Chapter 8: Gap Junctional Connexin43: Novel Insights from the New Millennium and Their Clinical Implications - p. g82 20. Part II: Biophysics of Cardiac Ion Channel Function - p. g96 21. Chapter 9: Computational Modeling and Simulation for Human Cardiac Electrophysiology: From Induced Pluripotent Stem Cell–Derived Cardiomyocytes to Adult Cardiomyocytes - p. g96 22. Chapter 10: Regulation of Cardiac Calcium Channels - p. g109 23. Chapter 11: Molecular Genetics of ATP-Sensitive Potassium Channels in Cardiovascular Diseases - p. g120 24. Chapter 12: Role of Enhancers in Transcriptional Regulation of Cardiac Electrical Activity - p. g133 25. Chapter 13: Functional Characterization of Ion Channel Gene Variants in Sudden Unexplained Natural Death - p. g141 26. Chapter 14: Stretch-Activated Potassium Channels in the Human Heart: Pathophysiologic and Clinical Significance - p. g152 27. Chapter 15: Connexins and Pannexins in Cardiovascular Disease - p. g164 28. Chapter 16: Excitation–Contraction Coupling - p. g174 29. Part III: Intermolecular Interactions and Cardiomyocyte Electrical Function - p. g186 30. Chapter 17: Ion Channel Trafficking in the Heart - p. g186 31. Chapter 18: Microdomain Interactions of Macromolecular Complexes and Regulation of the Sodium Channel NaV1.5 - p. g193 32. Chapter 19: Connecting Cardiac Excitation to the Atomic Interactions of Ion Channels - p. g206 33. Chapter 20: Macromolecular Complexes and Cardiac Potassium Channels - p. g216 34. Chapter 21: Reciprocity of Cardiac Sodium and Potassium Channels in the Control of Excitability and Arrhythmias - p. g225 35. Chapter 22: The Intercalated Disc: A Molecular Network That Integrates Electrical Coupling, Intercellular Adhesion, and Cell Excitability - p. g240 36. Chapter 23: Function and Dysfunction of Ion Channel Membrane Trafficking and Posttranslational Modification - p. g253 37. Chapter 24: Feedback Mechanisms for Cardiac-Specific microRNAs and cAMP Signaling in Electrical Remodeling - p. g263 38. Part IV: Cell Biology of Cardiac Impulse Initiation and Propagation - p. g272 39. Chapter 25: Coupled Oscillators and Sinoatrial Pacemaker Activity - p. g272 40. Chapter 26: Mapping of Cardiac Action Potentials in Zebrafish to Assess Genetic Variants - p. g287 41. Chapter 27: Cell-To-Cell Communication and Impulse Propagation - p. g300 42. Chapter 28: Mechanisms of Normal and Dysfunctional Sinoatrial Nodal Excitability and Propagation - p. g313 43. Chapter 29: Cell Biology of the Specialized Cardiac Conduction System - p. g328 44. Part V: Models of Cardiac Excitation - p. g340 45. Chapter 30: Computational Prediction of Drug-Induced Arrhythmias - p. g340 46. Chapter 31: Global Optimization Approaches to Generate Dynamically Robust Electrophysiologic Models - p. g349 47. Chapter 32: Calcium Signaling in Cardiomyocyte Models With Realistic Geometries - p. g360 48. Chapter 33: Theory of Rotors and Arrhythmias - p. g373 49. Chapter 34: Distinct ECG Phenotypes Identified in Hypertrophic Cardiomyopathy Using Machine Learning Associated With Arrhythmic Risk Markers - p. g385 50. Chapter 35: Computational Approaches for Accurate Rotor Localization in the Atria - p. g401 51. Chapter 36: Modeling the Aging Heart - p. g415 52. Chapter 37: Electromechanic Imaging of the Heart - p. g426 53. Part VI: Neural Control of Cardiac Electrical Activity - p. g442 54. Chapter 38: Innervation of the Sinoatrial Node - p. g442 55. Chapter 39: Autonomic and Oxidant Regulation of Cardiac Sodium Currents Mechanisms and Consequences - p. g450 56. Chapter 40: Neural Activity and Atrial Tachyarrhythmias - p. g457 57. Chapter 41: Sympathetic Modulation of Cardiac Electrophysiology - p. g470 58. Chapter 42: Role of the Autonomic Nervous System in Atrial Fibrillation - p. g479 59. Part VII: Arrhythmia Mechanisms - p. g487 60. Chapter 43: Rotational and Focal Sources of Atrial Fibrillation: Scientific Rationale and Comparative Clinical Mapping - p. g487 61. Chapter 44: Noninvasive Frequency-Phase Mapping of Atrial Fibrillation - p. g501 62. Chapter 45: Mechanistic Approaches for Persistent Atrial Fibrillation Ablation - p. g511 63. Chapter 46: Mechanisms of Human Ventricular Tachycardia and Human Ventricular Fibrillation - p. g526 64. Chapter 47: Genetics of Atrial Fibrillation - p. g541 65. Part VIII: Molecular Genetics and Pharmacogenomics - p. g550 66. Chapter 48: Mechanisms in Genetic Sodium Channel Diseases - p. g550 67. Chapter 49: Genetic, Ionic, and Cellular Mechanisms Underlying the J Wave Syndromes - p. g561 68. Chapter 50: Inheritable Potassium Channel Diseases - p. g576 69. Chapter 51: Inheritable Phenotypes Associated With Altered Intracellular Calcium Regulation - p. g591 70. Part IX: Pharmacologic, Genetic, and Cell Therapy of Ion Channel Dysfunction - p. g601 71. Chapter 52: Dominant Frequency as a Tool for Personalized Monitoring of Atrial Fibrillation Progression and Upstream Therapy - p. g601 72. Chapter 53: Pharmacogenomics of Cardiac Arrhythmias - p. g611 73. Chapter 54: Deep Phenotyping: Adding New Tools to Understand Disease - p. g620 74. Chapter 55: Gene Therapy for Atrial Fibrillation - p. g629 75. Part X: Cell Biology and Electrophysiology of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes - p. g640 76. Chapter 56: Cardiac Remodeling and Regeneration - p. g640 77. Chapter 57: High-Throughput Optical Mapping of Two-Dimensional hiPSC-CM Platforms for Drug Discovery and Cardiotoxicity Testing - p. g650 78. Chapter 58: Functional Cardiac Fibroblasts Derived From Human Pluripotent Stem Cells via Second Heart Field Progenitors - p. g666 79. Chapter 59: Challenges of Human iPSC-CM Technology: Increasingly Complex Approaches Improve Cell Maturation and Relevance to Modeling Human Cardiac Disease - p. g677 80. Part XI: Diagnostic Evaluation - p. g689 81. Chapter 60: Assessment of the Patient With a Cardiac Arrhythmia - p. g689 82. Chapter 61: Differential Diagnosis of Narrow and Wide Complex Tachycardias - p. g698 83. Chapter 62: Electrocardiographic Monitoring: Short- and Long-Term Recording - p. g706 84. Chapter 63: Personal Cardiac Monitoring - p. g714 85. Chapter 64: Computed Tomography for Electrophysiology - p. g725 86. Chapter 65: Magnetic Resonance Imaging for Electrophysiology - p. g741 87. Chapter 66: Intracardiac Echocardiography for Electrophysiology - p. g752 88. Chapter 67: Autonomic Nervous System Assessment for Syncope and Arrhythmia Risk - p. g762 89. Chapter 68: Noninvasive Electrocardiographic Imaging of Arrhythmogenic Substrates and Ventricular Arrhythmias - p. g771 90. Chapter 69: Genetic Testing - p. g785 91. Part XII: Supraventricular Arrhythmias: Diagnosis and Therapy - p. g791 92. Chapter 70: Supraventricular Tachycardias: Diagnostic Maneuvers in the Electrophysiology Laboratory - p. g791 93. Chapter 71: Atrial Tachycardia - p. g804 94. Chapter 72: Atrioventricular Nodal Reentrant Tachycardia - p. g825 95. Chapter 73: Junctional Tachycardia - p. g852 96. Chapter 74: Preexcitation, Atrioventricular Reentry, Variants - p. g860 97. Chapter 75: Atrial Fibrillation: Mechanisms, Clinical Features, and Management - p. g874 98. Chapter 76: Ablation for Atrial Fibrillation - p. g886 99. Chapter 77: Left Atrial Appendage Management: Anatomy, Physiology, and Role in Atrial Fibrillation–Related Stroke - p. g899 100. Chapter 78: Typical and Atypical Atrial Flutter: Mapping and Ablation - p. g907 101. Part XIII: Ventricular Arrhythmias - p. g921 102. Chapter 79: Sudden Cardiac Death in Adults - p. g921 103. Chapter 80: Premature Ventricular Complexes - p. g936 104. Chapter 81: Outflow Tract Ventricular Tachyarrhythmias: Mechanisms, Clinical Features, and Management - p. g944 105. Chapter 82: Premature Ventricular Contraction Ablation With Anatomic Guidance: Papillary Muscles, Moderator Band, and Valve Annulus Sites - p. g956 106. Chapter 83: Fascicular Ventricular Arrhythmias - p. g968 107. Chapter 84: Bundle Branch Reentry Tachycardia - p. g975 108. Chapter 85: Ischemic Heart Disease - p. g988.e1 109. Chapter 86: Ablation of Postmyocardial Infarction Ventricular Tachycardia - p. g999 110. Chapter 87: Ventricular Tachycardia in Patients With Dilated Cardiomyopathy - p. g1011 111. Chapter 88: Lamin A/C, Noncompaction, and Other Genetic Cardiomyopathies With Ventricular Arrhythmias - p. g1024 112. Chapter 89: Ventricular Tachyarrhythmias in Hypertrophic Cardiomyopathy: Sudden Death, Risk Stratification, and Prevention With Implantable Defibrillators - p. g1035 113. Chapter 90: Ventricular Tachycardias in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy - p. g1048 114. Chapter 91: Catecholaminergic Polymorphic Ventricular Tachycardia - p. g1059 115. Chapter 92: Arrhythmias and Conduction Disturbances in Noncompaction Cardiomyopathy - p. g1070 116. Chapter 93: Ventricular Arrhythmias in Takotsubo Cardiomyopathy - p. g1081 117. Chapter 94: Mitral Valve Prolapse, Ventricular Arrhythmias, and Sudden Death - p. g1087 118. Chapter 95: Brugada Syndrome - p. g1097 119. Chapter 96: Long and Short QT Syndromes - p. g1108 120. Chapter 97: Andersen-Tawil Syndrome - p. g1125 121. Chapter 98: Timothy Syndrome - p. g1134 122. Chapter 99: J Wave Syndromes - p. g1143 123. Chapter 100: Idiopathic and Short-Coupled Ventricular Fibrillation - p. g1155 124. Chapter 101: Mapping and Ablation of Ventricular Fibrillation - p. g1163 125. Chapter 102: Drug-Induced Ventricular Arrhythmias - p. g1174 126. Part XIV: Syncope and Bradyarrhythmias - p. g1187 127. Chapter 103: Syncope - p. g1187 128. Chapter 104: Sinus Node Abnormalities - p. g1195 129. Chapter 105: Postural Orthostatic Tachycardia Syndrome - p. g1201 130. Chapter 106: Atrioventricular Block - p. g1208 131. Part XV: Arrhythmias in Special Populations - p. g1216 132. Chapter 107: Sex Differences in Arrhythmias - p. g1216 133. Chapter 108: Sudden Cardiac Deaths in Athletes, Including Commotio Cordis - p. g1224 134. Chapter 109: Cardiac Sarcoidosis - p. g1235 135. Chapter 110: Sleep-Disordered Breathing and Arrhythmias - p. g1246 136. Chapter 111: Ventricular Assist Devices and Cardiac Transplant Recipients - p. g1255 137. Chapter 112: Arrhythmia in Neurologic Disease - p. g1264 138. Chapter 113: Cancer Therapy–Related Arrhythmias - p. g1278 139. Part XVI: Congenital Heart Disease and Pediatrics - p. g1292 140. Chapter 114: Arrhythmias in the Pediatric Population - p. g1292 141. Chapter 115: Supraventricular Tachycardias in Congenital Heart Disease - p. g1310 142. Chapter 116: Ventricular Arrhythmias in Congenital Heart Disease - p. g1327 143. Part XVII: Pharmacologic Therapy - p. g1344 144. Chapter 117: Antiarrhythmic Drugs - p. g1344 145. Chapter 118: Impact of Nontraditional Antiarrhythmic Drugs on Sudden Cardiac Death - p. g1359 146. Chapter 119: Anticoagulation for Thromboembolic Prophylaxis - p. g1368 147. Part XVIII: Devices for Arrhythmia Management - p. g1380 148. Chapter 120: Implantable Pacemakers - p. g1380 149. Chapter 121: Implantable Cardioverter-Defibrillators: Technical Aspects - p. g1393 150. Chapter 122: Transvenous Implantable Cardioverter-Defibrillator: Clinical Aspects - p. g1408 151. Chapter 123: Subcutaneous Implantable Cardioverter-Defibrillators - p. g1425 152. Chapter 124: Wearable Defibrillators - p. g1435 153. Chapter 125: Cardiac Resynchronization - p. g1444 154. Chapter 126: Management of Implanted Device Infections - p. g1457 155. Part XIX: Catheter and Surgical Mapping and Ablation - p. g1468 156. Chapter 127: Electrogram Recording and Signal Processing - p. g1468 157. Chapter 128: Electroanatomic Mapping for Arrhythmias - p. g1484 158. Chapter 129: Mapping Scar-Related Arrhythmias - p. g1502 159. Chapter 130: Radiofrequency Ablation - p. g1510 160. Chapter 131: Cryoablation and Other Radiofrequency Alternatives - p. g1527 161. Chapter 132: Transvascular Ethanol Ablation - p. g1539 162. Chapter 133: Cardiac Radioablation - p. g1554 163. Chapter 134: Epicardial Approach in Electrophysiology - p. g1563 164. Chapter 135: Surgery for Atrial Fibrillation and Other Supraventricular Tachycardias - p. g1578 165. Chapter 136: Surgery for Ventricular Arrhythmias - p. g1593 166. Chapter 137: Neuromodulation for the Treatment of Arrhythmias - p. g1607 167. Part XX: Drug Discovery for Cardiac Arrhythmias - p. g1617 168. Chapter 138: Drug Discovery for Myocardial Diseases and Cardiac Arrhythmias Using Zebrafish - p. g1617 169. Index - p. g1628
