Autophagy Dysfunction in Alzheimer’s Disease and Dementia provides an overview for researchers and clinicians on the mechanisms involved in protein degradation in Alzheimer’s. The book discusses the implication of autophagy dysfunction in these diseases and how it causes degenerated proteins, including aggregated tau and aggregated amyloid protein. Other sections explores the possibilities of potential drug development through autophagy modulation, making this a great resource on the study of how autophagy dysfunction has been linked to the accumulation of misfolded proteins that cause death of neurons in Alzheimer’s and other neurodegenerative diseases.
1. Autophagy Dysfunction in Alzheimer’s Disease and Dementia - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. Dedication - p. v 7. Contributors - p. xiii 8. Foreword - p. xvii 9. Preface - p. xix 10. Acknowledgments - p. xxi 11. Chapter 1 Degradation mechanisms of cells - p. 1 12. Chapter 2 Lysosomes-neuronal degeneration in lysosomal storage disorders - p. 25 13. Chapter 3 The autophagy pathway and its key regulators - p. 47 14. Chapter 4 Basics of amyloid β-protein in Alzheimer’s disease - p. 73 15. Chapter 5 Molecular linkages among Aβ, tau, impaired mitophagy, and mitochondrial dysfunction in Alzheimer’s disease - p. 91 16. Chapter 6 Endocytosis in β-amyloid biology and Alzheimer’s disease - p. 111 17. Chapter 7 Autophagy and tau protein - p. 135 18. Chapter 8 BAG3 promotes tau clearance by regulating autophagy and other vacuolar-dependent degradative processes - p. 159 19. Chapter 9 Tau propagation and autophagy - p. 173 20. Chapter 10 Granulovacuolar degeneration in neurodegeneration - p. 197 21. Chapter 11 Autophagy dysfunction in skeletal myopathies: Inclusion body myositis and Danon disease - p. 207 22. Chapter 12 Autophagy in Lewy body diseases and multiple system atrophy - p. 227 23. Chapter 13 Autophagy and Huntington’s disease - p. 245 24. Chapter 14 Drug discovery in Alzheimer’s disease by regulating autophagy - p. 263 25. Chapter 15 Drug discovery in Alzheimer’s disease using metal chelators: Warning toward their usage - p. 291 26. Chapter 16 Development of autophagy enhancers for Parkinson’s disease therapy - p. 305 27. Index - p. 321
Autophagy Dysfunction in Alzheimer’s Disease and Dementia provides an overview for researchers and clinicians on the mechanisms involved in protein degradation in Alzheimer’s. The book discusses the implication of autophagy dysfunction in these diseases and how it causes degenerated proteins, including aggregated tau and aggregated amyloid protein. Other sections explores the possibilities of potential drug development through autophagy modulation, making this a great resource on the study of how autophagy dysfunction has been linked to the accumulation of misfolded proteins that cause death of neurons in Alzheimer’s and other neurodegenerative diseases.
1. Autophagy Dysfunction in Alzheimer’s Disease and Dementia - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. Dedication - p. v 7. Contributors - p. xiii 8. Foreword - p. xvii 9. Preface - p. xix 10. Acknowledgments - p. xxi 11. Chapter 1 Degradation mechanisms of cells - p. 1 12. Chapter 2 Lysosomes-neuronal degeneration in lysosomal storage disorders - p. 25 13. Chapter 3 The autophagy pathway and its key regulators - p. 47 14. Chapter 4 Basics of amyloid β-protein in Alzheimer’s disease - p. 73 15. Chapter 5 Molecular linkages among Aβ, tau, impaired mitophagy, and mitochondrial dysfunction in Alzheimer’s disease - p. 91 16. Chapter 6 Endocytosis in β-amyloid biology and Alzheimer’s disease - p. 111 17. Chapter 7 Autophagy and tau protein - p. 135 18. Chapter 8 BAG3 promotes tau clearance by regulating autophagy and other vacuolar-dependent degradative processes - p. 159 19. Chapter 9 Tau propagation and autophagy - p. 173 20. Chapter 10 Granulovacuolar degeneration in neurodegeneration - p. 197 21. Chapter 11 Autophagy dysfunction in skeletal myopathies: Inclusion body myositis and Danon disease - p. 207 22. Chapter 12 Autophagy in Lewy body diseases and multiple system atrophy - p. 227 23. Chapter 13 Autophagy and Huntington’s disease - p. 245 24. Chapter 14 Drug discovery in Alzheimer’s disease by regulating autophagy - p. 263 25. Chapter 15 Drug discovery in Alzheimer’s disease using metal chelators: Warning toward their usage - p. 291 26. Chapter 16 Development of autophagy enhancers for Parkinson’s disease therapy - p. 305 27. Index - p. 321
