Functional Neural Transplantation IV: Translation to Clinical Application, Volume 230 provides the current status of cell transplantation in the nervous system, with a focus on the conditions for achieving structural repair and functional recovery after brain damage or in neurodegenerative disease. New to this release are chapters that delve into the Mechanisms and Use of Neural Transplants for Brain Repair, Reprogramming of Somatic Cells: iPS and iN Cells, Brain Repair from Intrinsic Cell Sources: Turning Reactive Glia into Neurons, and Ex Vivo Gene Therapy for the Treatment of Neurological Disorders, Preparation, Characterization and Banking of Clinical-grade Cells for Neural Transplantation.
As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments related to the application of advances in cellular and molecular science, providing an understanding of the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, and also addressing the topic of the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. v 6. Preface - p. xxv 7. Chapter 1: Mechanisms and use of neural transplants for brain repair - p. xxvii 8. Chapter 2: Reprogramming of somatic cells: iPS and iN cells - p. 51 9. Chapter 3: Brain repair from intrinsic cell sources: Turning reactive glia into neurons - p. 68 10. Chapter 4: Ex vivo gene therapy for the treatment of neurological disorders - p. 97 11. Chapter 5: Preparation, characterization, and banking of clinical-grade cells for neural transplantation: Scale up, fingerprinting, and genomic stability of stem cell lines - p. 132 12. Chapter 6: Regulatory considerations for pluripotent stem cell therapies - p. 150 13. Chapter 7: Strategies for bringing stem cell-derived dopamine neurons to the clinic: A European approach (STEM-PD) - p. 163 14. Chapter 8: Strategies for bringing stem cell-derived dopamine neurons to the clinic—The NYSTEM trial - p. 190 15. Chapter 9: Strategies for bringing stem cell-derived dopamine neurons to the clinic: The Kyoto trial - p. 212 16. Chapter 10: From open to large-scale randomized cell transplantation trials in Huntington's disease: Lessons from the multicentric intracerebral grafting in Huntington's disease trial (MIG-HD) and previous pilot studies - p. 226 17. Chapter 11: Pluripotent stem cell-derived neurons for transplantation in Huntington's disease - p. 261 18. Chapter 12: Advanced imaging of transplant survival, fate, differentiation, and integration - p. 281 19. Chapter 13: Rehabilitation training in neural restitution - p. 303 20. Combined Index - p. 331
Functional Neural Transplantation IV: Translation to Clinical Application, Volume 230 provides the current status of cell transplantation in the nervous system, with a focus on the conditions for achieving structural repair and functional recovery after brain damage or in neurodegenerative disease. New to this release are chapters that delve into the Mechanisms and Use of Neural Transplants for Brain Repair, Reprogramming of Somatic Cells: iPS and iN Cells, Brain Repair from Intrinsic Cell Sources: Turning Reactive Glia into Neurons, and Ex Vivo Gene Therapy for the Treatment of Neurological Disorders, Preparation, Characterization and Banking of Clinical-grade Cells for Neural Transplantation.
As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments related to the application of advances in cellular and molecular science, providing an understanding of the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, and also addressing the topic of the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. v 6. Preface - p. xxv 7. Chapter 1: Mechanisms and use of neural transplants for brain repair - p. xxvii 8. Chapter 2: Reprogramming of somatic cells: iPS and iN cells - p. 51 9. Chapter 3: Brain repair from intrinsic cell sources: Turning reactive glia into neurons - p. 68 10. Chapter 4: Ex vivo gene therapy for the treatment of neurological disorders - p. 97 11. Chapter 5: Preparation, characterization, and banking of clinical-grade cells for neural transplantation: Scale up, fingerprinting, and genomic stability of stem cell lines - p. 132 12. Chapter 6: Regulatory considerations for pluripotent stem cell therapies - p. 150 13. Chapter 7: Strategies for bringing stem cell-derived dopamine neurons to the clinic: A European approach (STEM-PD) - p. 163 14. Chapter 8: Strategies for bringing stem cell-derived dopamine neurons to the clinic—The NYSTEM trial - p. 190 15. Chapter 9: Strategies for bringing stem cell-derived dopamine neurons to the clinic: The Kyoto trial - p. 212 16. Chapter 10: From open to large-scale randomized cell transplantation trials in Huntington's disease: Lessons from the multicentric intracerebral grafting in Huntington's disease trial (MIG-HD) and previous pilot studies - p. 226 17. Chapter 11: Pluripotent stem cell-derived neurons for transplantation in Huntington's disease - p. 261 18. Chapter 12: Advanced imaging of transplant survival, fate, differentiation, and integration - p. 281 19. Chapter 13: Rehabilitation training in neural restitution - p. 303 20. Combined Index - p. 331
