Genome Damage: Repair and Adaptation Across Life explores the significance of nucleic acid damage from environmental pollutants, UV radiation, and other stressors that can lead to mutations, genetic instability, and various diseases, including cancer. This book delves into the mechanisms of DNA and RNA repair, which are crucial for maintaining cellular health and enabling evolutionary adaptations. It examines these intricate processes across microbes, plants, and animals, providing a comprehensive understanding of how genetic materials are regulated and repaired under diverse environmental conditions.
Other sections cover a wide range of topics, including advanced molecular mechanisms of nucleotide repair, UV-induced damage, apoptosis cell death and autophagy, genetic instability in crops, and the role of post-translational modifications in DNA repair, the detection and quantification of DNA damage, the impact of synthetic chemicals and climate change on nucleic acids, and the therapeutic significance of DNA repair mechanisms. The book closes with a look towards future perspectives.
1. Cover image - p. c 2. Title page - p. i 3. Copyright - p. ii 4. Contents - p. v 5. Contributors - p. xi 6. About the editors - p. xv 7. Chapter 1 Genome research: Basic concept and recent advances - p. 1 8. Chapter 2 UV-mediated damage and repair in bacterial communities - p. 35 9. Chapter 3 Implications of oxidative stress on microbial evolution - p. 49 10. Chapter 4 DNA photolyase: Structure, mode of action, and therapeutic applications - p. 75 11. Chapter 5 DNA repair in extremophiles - p. 91 12. Chapter 6 Recent developments in ultraviolet-induced deoxyribonucleic acid damage and repair in higher plants - p. 115 13. Chapter 7 Molecular dynamics of ultraviolet-B induced DNA lesions and repair mechanisms in higher plants - p. 131 14. Chapter 8 Ionizing radiation-induced mammalian cell damage and repairs - p. 155 15. Chapter 9 Ultraviolet-induced DNA damage and repair in mammals - p. 173 16. Chapter 10 Oxidative DNA damage: Repair mechanisms and associated disorders in humans - p. 197 17. Chapter 11 Detection of DNA damage and repair: A technological development - p. 227 18. Chapter 12 Perfluorinated compounds in fish: Ecotoxicological effects, DNA damage and implications for aquatic and human health - p. 241 19. Chapter 13 Effects of climate change on nucleic acid composition - p. 259 20. Chapter 14 RNA damage and repair mechanisms - p. 283 21. Chapter 15 DNA damage and cancer: Advances, risk assessment, and opportunities - p. 305 22. Chapter 16 Metal stress, DNA damage, and mutagenesis: Molecular mechanisms and health consequences - p. 331 23. Chapter 17 Apoptosis: Cell death and damage - p. 359 24. Chapter 18 Phytochemical modulation of DNA repair: Mechanisms, epigenetics, and therapeutic potential - p. 387 25. Chapter 19 Significance of algal green chemicals in repair mechanisms - p. 417 26. Chapter 20 Phyco-chemicals in DNA repair: Algal and cyanobacterial antioxidants and epigenetic modulators in cellular defense - p. 437 27. Chapter 21 DNA damage, aging concept: Feasibility and significance - p. 465 28. Chapter 22 Structural and dynamic signatures of DNA damage in Leishmania : Mechanisms, implications, and therapeutic perspectives - p. 491 29. Chapter 23 Impacts of nanoparticles on DNA damage and repair - p. 515 30. Chapter 24 DNA mutagenesis and genomic instability induced by heavy metals: Biological and environmental perspectives - p. 541 31. Chapter 25 Significance of plant nutraceuticals in DNA repair - p. 567 32. Chapter 26 DNA damage and repair: Future perspectives - p. 595 33. Index - p. 619
Genome Damage: Repair and Adaptation Across Life explores the significance of nucleic acid damage from environmental pollutants, UV radiation, and other stressors that can lead to mutations, genetic instability, and various diseases, including cancer. This book delves into the mechanisms of DNA and RNA repair, which are crucial for maintaining cellular health and enabling evolutionary adaptations. It examines these intricate processes across microbes, plants, and animals, providing a comprehensive understanding of how genetic materials are regulated and repaired under diverse environmental conditions.
Other sections cover a wide range of topics, including advanced molecular mechanisms of nucleotide repair, UV-induced damage, apoptosis cell death and autophagy, genetic instability in crops, and the role of post-translational modifications in DNA repair, the detection and quantification of DNA damage, the impact of synthetic chemicals and climate change on nucleic acids, and the therapeutic significance of DNA repair mechanisms. The book closes with a look towards future perspectives.
1. Cover image - p. c 2. Title page - p. i 3. Copyright - p. ii 4. Contents - p. v 5. Contributors - p. xi 6. About the editors - p. xv 7. Chapter 1 Genome research: Basic concept and recent advances - p. 1 8. Chapter 2 UV-mediated damage and repair in bacterial communities - p. 35 9. Chapter 3 Implications of oxidative stress on microbial evolution - p. 49 10. Chapter 4 DNA photolyase: Structure, mode of action, and therapeutic applications - p. 75 11. Chapter 5 DNA repair in extremophiles - p. 91 12. Chapter 6 Recent developments in ultraviolet-induced deoxyribonucleic acid damage and repair in higher plants - p. 115 13. Chapter 7 Molecular dynamics of ultraviolet-B induced DNA lesions and repair mechanisms in higher plants - p. 131 14. Chapter 8 Ionizing radiation-induced mammalian cell damage and repairs - p. 155 15. Chapter 9 Ultraviolet-induced DNA damage and repair in mammals - p. 173 16. Chapter 10 Oxidative DNA damage: Repair mechanisms and associated disorders in humans - p. 197 17. Chapter 11 Detection of DNA damage and repair: A technological development - p. 227 18. Chapter 12 Perfluorinated compounds in fish: Ecotoxicological effects, DNA damage and implications for aquatic and human health - p. 241 19. Chapter 13 Effects of climate change on nucleic acid composition - p. 259 20. Chapter 14 RNA damage and repair mechanisms - p. 283 21. Chapter 15 DNA damage and cancer: Advances, risk assessment, and opportunities - p. 305 22. Chapter 16 Metal stress, DNA damage, and mutagenesis: Molecular mechanisms and health consequences - p. 331 23. Chapter 17 Apoptosis: Cell death and damage - p. 359 24. Chapter 18 Phytochemical modulation of DNA repair: Mechanisms, epigenetics, and therapeutic potential - p. 387 25. Chapter 19 Significance of algal green chemicals in repair mechanisms - p. 417 26. Chapter 20 Phyco-chemicals in DNA repair: Algal and cyanobacterial antioxidants and epigenetic modulators in cellular defense - p. 437 27. Chapter 21 DNA damage, aging concept: Feasibility and significance - p. 465 28. Chapter 22 Structural and dynamic signatures of DNA damage in Leishmania : Mechanisms, implications, and therapeutic perspectives - p. 491 29. Chapter 23 Impacts of nanoparticles on DNA damage and repair - p. 515 30. Chapter 24 DNA mutagenesis and genomic instability induced by heavy metals: Biological and environmental perspectives - p. 541 31. Chapter 25 Significance of plant nutraceuticals in DNA repair - p. 567 32. Chapter 26 DNA damage and repair: Future perspectives - p. 595 33. Index - p. 619
