In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body’s ability to mobilize endogenous stem cells to the site of injury and details the latest strategies developed for inducing and supporting the body’s own regenerating capacity. From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies. The work is divided into four sections to provide a thorough overview and helpful hints for future discoveries: endogenous cell sources; biochemical and physical cues; smart biomaterial development; and applications.
1. Part 1. Introduction - p. xix 2. Chapter 1. Fundamentals of In Situ Tissue Regeneration - p. 3 3. Part 2. Endogenous Cell Sources - p. 17 4. Chapter 2. Stem Cell Homing - p. 21 5. Chapter 3. Immunology: Host Responses to Biomaterials - p. 35 6. Chapter 4. Foreign Body Reaction and Stem Cell Responses - p. 49 7. Part 3. Biochemical and Physical Cues - p. 69 8. Chapter 5. Roles of Endogenous Growth Factors and Small Peptides in In Situ Tissue Regeneration - p. 73 9. Chapter 6. Small Molecules: Controlling Cell Fate and Function - p. 87 10. Chapter 7. Small RNA Delivery for In Situ Tissue Regeneration - p. 111 11. Chapter 8. Micro- and Nanotopographical Cues Guiding Biomaterial Host Response - p. 137 12. Chapter 9. Mechanobiology and Mechanotherapy in Tissue Engineering - p. 165 13. Part 4. Smart Biomaterials Development - p. 181 14. Chapter 10. A Biomimetic Strategy to Design Biomaterials for In Situ Tissue Regeneration - p. 185 15. Chapter 11. Impact of Matrix Dynamic Properties on Stem Cell Viability - p. 203 16. Chapter 12. Functionalized Polymeric Biomaterials for In Situ Tissue Regeneration - p. 215 17. Chapter 13. Tissue-Derived Matrices - p. 229 18. Part 5. Tissue-Specific Applications - p. 250 19. Chapter 14. Synovial Joint: In Situ Regeneration of Osteochondral and Fibrocartilaginous Tissues by Homing of Endogenous Cells - p. 253 20. Chapter 15. Bioengineered Strategies for Tendon Regeneration - p. 275 21. Chapter 16. In Situ Volumetric Muscle Repair - p. 295 22. Chapter 17. Mending the Heart Through In Situ Cardiac Regeneration - p. 313 23. Chapter 18. Skin Wound Healing: Skin Regeneration With Pharmacological Mobilized Stem Cells - p. 345 24. Chapter 19. In Situ Renal Regeneration - p. 369 25. Chapter 20. Regulatory Aspects: Regulation of Cell-Free Biomaterial Implants - p. 383 26. Chapter 21. Business Perspective: Case Study: Commercialized Cell-Free Cardiovascular Implant - p. 405 27. Index - p. 421
In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body’s ability to mobilize endogenous stem cells to the site of injury and details the latest strategies developed for inducing and supporting the body’s own regenerating capacity. From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies. The work is divided into four sections to provide a thorough overview and helpful hints for future discoveries: endogenous cell sources; biochemical and physical cues; smart biomaterial development; and applications.
1. Part 1. Introduction - p. xix 2. Chapter 1. Fundamentals of In Situ Tissue Regeneration - p. 3 3. Part 2. Endogenous Cell Sources - p. 17 4. Chapter 2. Stem Cell Homing - p. 21 5. Chapter 3. Immunology: Host Responses to Biomaterials - p. 35 6. Chapter 4. Foreign Body Reaction and Stem Cell Responses - p. 49 7. Part 3. Biochemical and Physical Cues - p. 69 8. Chapter 5. Roles of Endogenous Growth Factors and Small Peptides in In Situ Tissue Regeneration - p. 73 9. Chapter 6. Small Molecules: Controlling Cell Fate and Function - p. 87 10. Chapter 7. Small RNA Delivery for In Situ Tissue Regeneration - p. 111 11. Chapter 8. Micro- and Nanotopographical Cues Guiding Biomaterial Host Response - p. 137 12. Chapter 9. Mechanobiology and Mechanotherapy in Tissue Engineering - p. 165 13. Part 4. Smart Biomaterials Development - p. 181 14. Chapter 10. A Biomimetic Strategy to Design Biomaterials for In Situ Tissue Regeneration - p. 185 15. Chapter 11. Impact of Matrix Dynamic Properties on Stem Cell Viability - p. 203 16. Chapter 12. Functionalized Polymeric Biomaterials for In Situ Tissue Regeneration - p. 215 17. Chapter 13. Tissue-Derived Matrices - p. 229 18. Part 5. Tissue-Specific Applications - p. 250 19. Chapter 14. Synovial Joint: In Situ Regeneration of Osteochondral and Fibrocartilaginous Tissues by Homing of Endogenous Cells - p. 253 20. Chapter 15. Bioengineered Strategies for Tendon Regeneration - p. 275 21. Chapter 16. In Situ Volumetric Muscle Repair - p. 295 22. Chapter 17. Mending the Heart Through In Situ Cardiac Regeneration - p. 313 23. Chapter 18. Skin Wound Healing: Skin Regeneration With Pharmacological Mobilized Stem Cells - p. 345 24. Chapter 19. In Situ Renal Regeneration - p. 369 25. Chapter 20. Regulatory Aspects: Regulation of Cell-Free Biomaterial Implants - p. 383 26. Chapter 21. Business Perspective: Case Study: Commercialized Cell-Free Cardiovascular Implant - p. 405 27. Index - p. 421
