Learn the what, how, and why of pathophysiology! With easy-to-read, in-depth descriptions of disease, disease etiology, and disease processes, McCance and Huether’s Pathophysiology: The Biologic Basis for Disease in Adults and Children, 9th Edition helps you understand the most important and most complex pathophysiology concepts. This updated text includes more than 1,300 full-color illustrations and photographs to make it easier to identify normal anatomy and physiology, as well as alterations of function. It’s the most comprehensive and authoritative pathophysiology text available!
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Emerging Science Boxes - p. iii 6. Evolve Student Resources - p. IFC1 7. Copyright - p. iv 8. Dedication - p. v 9. Contributors - p. vii 10. Preface - p. ix 11. Acknowledgments - p. xii 12. Part One: Central Concepts of Pathophysiology: Cells and Tissues - p. 1 13. Unit I: The Cell - p. 1a 14. 1. Cellular Biology - p. 1b 15. 2. Altered Cellular and Tissue Biology: Environmental Agents - p. 43 16. Chapter Outline - p. 43 17. Cellular Adaptation - p. 44 18. Cellular Injury - p. 47 19. Manifestations of Cellular Injury - p. 80 20. Cellular Death - p. 85 21. Aging and Altered Cellular and Tissue Biology - p. 91 22. Somatic Death - p. 95 23. Summary Review - p. 97 24. References - p. 100 25. 3. The Cellular Environment: Fluids and Electrolytes, Acids and Bases - p. 106 26. Unit II: Genes and Gene-Environment Interaction - p. 140 27. 4. Genes and Genetic Diseases - p. 140a 28. 5. Genes, Environment-Lifestyle, and Common Diseases - p. 167 29. 6. Epigenetics and Disease - p. 187 30. Unit III: Mechanisms of Self-Defense - p. 202 31. 7. Innate Immunity Inflammation and Wound Healing - p. 202a 32. 8. Adaptive Immunity - p. 231 33. 9. Alterations in Immunity - p. 255 34. 10. Infection - p. 281 35. 11. Stress and Disease - p. 310 36. Unit IV: Cellular Proliferation: Cancer - p. 331 37. 12. Cancer Biology - p. 331a 38. Outline - p. 331a 39. Cancer Terminology and Characteristics - p. 331a 40. The Biology of Cancer Cells - p. 334 41. Activating Invasion and Metastasis - p. 354 42. Clinical Manifestations of Cancer - p. 367 43. Diagnosis and Staging of Cancer - p. 371 44. Treatment of Cancer - p. 373 45. Targeted Disruption of Cancer - p. 376 46. Summary Review - p. 376 47. References - p. 381 48. 13. Cancer Epidemiology - p. 388 49. CHAPTER Outline - p. 388 50. Incidence, Mortality Trends, and Race - p. 388 51. Genetics, Epigenetics, Tumor Microenvironment, and Cellular Signaling in Cancer - p. 395 52. In Utero and Early Life Conditions - p. 397 53. Environmental-Lifestyle Factors - p. 399 54. Summary Review - p. 422 55. References - p. 426 56. 14. Cancer in Children and Adolescents - p. 430 57. Part Two: Structure, Function, and Pathophysiologic Alterations: Organs and Systems - p. 441 58. Unit V: The Neurologic System - p. 441a 59. 15. Structure and Function of the Neurologic System - p. 441b 60. 16. Pain, Temperature Regulation, Sleep, and Sensory Function - p. 474 61. 17. Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function - p. 509 62. Chapter Outline - p. 509 63. Alterations in Cognitive Systems - p. 509 64. Alterations in Cerebral Hemodynamics - p. 534 65. Alterations in Neuromotor Function - p. 538 66. Chronic Diseases and Disorders Involving Motor Function - p. 547 67. Summary Review - p. 563 68. References - p. 565 69. 18. Alterations of the Brain, Spinal Cord, and Peripheral Nerves - p. 570 70. Chapter Outline - p. 570 71. Central Nervous System Disorders - p. 570 72. Infection and Inflammation of the Central Nervous System - p. 599 73. Peripheral Nervous System Disorders - p. 605 74. Tumors of the Central Nervous System - p. 606 75. Summary Review - p. 611 76. References - p. 613 77. 19. Neurobiology of Schizophrenia, Mood Disorders, Anxiety Disorders, Posttraumatic Stress Disorder, and Obsessive-Compulsive Disorder - p. 618 78. 20. Alterations of Neurologic Function in Children - p. 640 79. Unit VI: The Endocrine System - p. 662 80. 21. Mechanisms of Hormonal Regulation - p. 662a 81. 22. Alterations of Hormonal Regulation - p. 688 82. 23. Obesity, Starvation, and Anorexia of Aging - p. 723 83. Unit VII: The Reproductive Systems - p. 738 84. 24. Structure and Function of the Reproductive Systems - p. 738a 85. 25. Alterations of the Female Reproductive System - p. 767 86. Chapter Outline - p. 767 87. Abnormalities of the Female Reproductive Tract - p. 767 88. Alterations of Sexual Maturation - p. 768 89. Disorders of the Female Reproductive System - p. 770 90. Disorders of the Female Breast - p. 802 91. Summary Review - p. 814 92. References - p. 816 93. 26. Alterations of the Male Reproductive System - p. 822 94. Chapter Outline - p. 822 95. Alterations of Sexual Maturation - p. 823 96. Disorders of the Male Reproductive System - p. 825 97. Disorders of the Male Breast - p. 855 98. Summary Review - p. 856 99. References - p. 857 100. Online References - p. 864.e1 101. 27. Sexually Transmitted Infections - p. 865 102. Unit VIII: The Hematologic System - p. 892 103. 28. Structure and Function of the Hematologic System - p. 892a 104. 29. Alterations of Hematologic Function - p. 925 105. Chapter Outline - p. 925 106. Anemia - p. 925 107. Myeloproliferative Red Cell Disorders - p. 939 108. Alterations of Leukocyte Function - p. 942 109. Alterations of Lymphoid Function - p. 957 110. Alterations of Splenic Function - p. 966 111. Hemorrhagic Disorders and Alterations of Platelets and Coagulation - p. 967 112. Summary Review - p. 979 113. References - p. 983 114. 30. Alterations of Hematologic Function in Children - p. 987 115. Unit IX: The Cardiovascular and Lymphatic Systems - p. 1020 116. 31. Structure and Function of the Cardiovascular and Lymphatic Systems - p. 1020a 117. 32. Alterations of Cardiovascular Function - p. 1059 118. Chapter Outline - p. 1059 119. Diseases of the Veins - p. 1059 120. Diseases of the Arteries - p. 1061 121. Disorders of the Heart Wall - p. 1084 122. Manifestations of Heart Disease - p. 1096 123. Summary Review - p. 1102 124. References - p. 1105 125. 33. Alterations of Cardiovascular Function in Children - p. 1109 126. Unit X: The Pulmonary System - p. 1131 127. 34. Structure and Function of the Pulmonary System - p. 1131a 128. 35. Alterations of Pulmonary Function - p. 1153 129. Chapter Outline - p. 1153 130. Clinical Manifestations of Pulmonary Alterations - p. 1153 131. Disorders of the Chest wall and Pleura - p. 1158 132. Pulmonary Disorders - p. 1161 133. Summary Review - p. 1186 134. References - p. 1187 135. 36. Alterations of Pulmonary Function in Children - p. 1191 136. Unit XI: The Renal and Urologic Systems - p. 1211 137. 37. Structure and Function of the Renal and Urologic Systems - p. 1211a 138. 38. Alterations of Renal and Urinary Tract Function - p. 1232 139. 39. Alterations of Renal and Urinary Tract Function in Children - p. 1270 140. Unit XII: The Digestive System - p. 1285 141. 40. Structure and Function of the Digestive System - p. 1285a 142. 41. Alterations of Digestive Function - p. 1318 143. Chapter Outline - p. 1318 144. Disorders of the Gastrointestinal Tract - p. 1318 145. Disorders of the accessory Organs of Digestion - p. 1342 146. Cancer of the Digestive System - p. 1357 147. Summary Review - p. 1366 148. References - p. 1370 149. 42. Alterations of Digestive Function in Children - p. 1375 150. Unit XIII: The Musculoskeletal System - p. 1399 151. 43. Structure and Function of the Musculoskeletal System - p. 1399a 152. 44. Alterations of Musculoskeletal Function - p. 1427 153. Chapter Outline - p. 1427 154. Musculoskeletal Injuries - p. 1427 155. Disorders of Bones - p. 1437 156. Disorders of Joints - p. 1452 157. Disorders of Skeletal Muscle - p. 1462 158. Muscle Tumors - p. 1470 159. Summary Review - p. 1471 160. References - p. 1473 161. 45. Alterations of Musculoskeletal Function in Children - p. 1476 162. Unit XIV: The Integumentary System - p. 1504 163. 46. Structure, Function, and Disorders of the Integument - p. 1504a 164. 47. Alterations of the Integument in Children - p. 1541 165. Unit XV: Multiple Interacting Systems - p. 1557 166. 48. Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults - p. 1557a 167. 49. Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children - p. 1591 168. Glossary - p. 1622 169. Index - p. 1645 170. Common Laboratory Values - p. IBC1
Learn the what, how, and why of pathophysiology! With easy-to-read, in-depth descriptions of disease, disease etiology, and disease processes, McCance and Huether’s Pathophysiology: The Biologic Basis for Disease in Adults and Children, 9th Edition helps you understand the most important and most complex pathophysiology concepts. This updated text includes more than 1,300 full-color illustrations and photographs to make it easier to identify normal anatomy and physiology, as well as alterations of function. It’s the most comprehensive and authoritative pathophysiology text available!
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Emerging Science Boxes - p. iii 6. Evolve Student Resources - p. IFC1 7. Copyright - p. iv 8. Dedication - p. v 9. Contributors - p. vii 10. Preface - p. ix 11. Acknowledgments - p. xii 12. Part One: Central Concepts of Pathophysiology: Cells and Tissues - p. 1 13. Unit I: The Cell - p. 1a 14. 1. Cellular Biology - p. 1b 15. 2. Altered Cellular and Tissue Biology: Environmental Agents - p. 43 16. Chapter Outline - p. 43 17. Cellular Adaptation - p. 44 18. Cellular Injury - p. 47 19. Manifestations of Cellular Injury - p. 80 20. Cellular Death - p. 85 21. Aging and Altered Cellular and Tissue Biology - p. 91 22. Somatic Death - p. 95 23. Summary Review - p. 97 24. References - p. 100 25. 3. The Cellular Environment: Fluids and Electrolytes, Acids and Bases - p. 106 26. Unit II: Genes and Gene-Environment Interaction - p. 140 27. 4. Genes and Genetic Diseases - p. 140a 28. 5. Genes, Environment-Lifestyle, and Common Diseases - p. 167 29. 6. Epigenetics and Disease - p. 187 30. Unit III: Mechanisms of Self-Defense - p. 202 31. 7. Innate Immunity Inflammation and Wound Healing - p. 202a 32. 8. Adaptive Immunity - p. 231 33. 9. Alterations in Immunity - p. 255 34. 10. Infection - p. 281 35. 11. Stress and Disease - p. 310 36. Unit IV: Cellular Proliferation: Cancer - p. 331 37. 12. Cancer Biology - p. 331a 38. Outline - p. 331a 39. Cancer Terminology and Characteristics - p. 331a 40. The Biology of Cancer Cells - p. 334 41. Activating Invasion and Metastasis - p. 354 42. Clinical Manifestations of Cancer - p. 367 43. Diagnosis and Staging of Cancer - p. 371 44. Treatment of Cancer - p. 373 45. Targeted Disruption of Cancer - p. 376 46. Summary Review - p. 376 47. References - p. 381 48. 13. Cancer Epidemiology - p. 388 49. CHAPTER Outline - p. 388 50. Incidence, Mortality Trends, and Race - p. 388 51. Genetics, Epigenetics, Tumor Microenvironment, and Cellular Signaling in Cancer - p. 395 52. In Utero and Early Life Conditions - p. 397 53. Environmental-Lifestyle Factors - p. 399 54. Summary Review - p. 422 55. References - p. 426 56. 14. Cancer in Children and Adolescents - p. 430 57. Part Two: Structure, Function, and Pathophysiologic Alterations: Organs and Systems - p. 441 58. Unit V: The Neurologic System - p. 441a 59. 15. Structure and Function of the Neurologic System - p. 441b 60. 16. Pain, Temperature Regulation, Sleep, and Sensory Function - p. 474 61. 17. Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function - p. 509 62. Chapter Outline - p. 509 63. Alterations in Cognitive Systems - p. 509 64. Alterations in Cerebral Hemodynamics - p. 534 65. Alterations in Neuromotor Function - p. 538 66. Chronic Diseases and Disorders Involving Motor Function - p. 547 67. Summary Review - p. 563 68. References - p. 565 69. 18. Alterations of the Brain, Spinal Cord, and Peripheral Nerves - p. 570 70. Chapter Outline - p. 570 71. Central Nervous System Disorders - p. 570 72. Infection and Inflammation of the Central Nervous System - p. 599 73. Peripheral Nervous System Disorders - p. 605 74. Tumors of the Central Nervous System - p. 606 75. Summary Review - p. 611 76. References - p. 613 77. 19. Neurobiology of Schizophrenia, Mood Disorders, Anxiety Disorders, Posttraumatic Stress Disorder, and Obsessive-Compulsive Disorder - p. 618 78. 20. Alterations of Neurologic Function in Children - p. 640 79. Unit VI: The Endocrine System - p. 662 80. 21. Mechanisms of Hormonal Regulation - p. 662a 81. 22. Alterations of Hormonal Regulation - p. 688 82. 23. Obesity, Starvation, and Anorexia of Aging - p. 723 83. Unit VII: The Reproductive Systems - p. 738 84. 24. Structure and Function of the Reproductive Systems - p. 738a 85. 25. Alterations of the Female Reproductive System - p. 767 86. Chapter Outline - p. 767 87. Abnormalities of the Female Reproductive Tract - p. 767 88. Alterations of Sexual Maturation - p. 768 89. Disorders of the Female Reproductive System - p. 770 90. Disorders of the Female Breast - p. 802 91. Summary Review - p. 814 92. References - p. 816 93. 26. Alterations of the Male Reproductive System - p. 822 94. Chapter Outline - p. 822 95. Alterations of Sexual Maturation - p. 823 96. Disorders of the Male Reproductive System - p. 825 97. Disorders of the Male Breast - p. 855 98. Summary Review - p. 856 99. References - p. 857 100. Online References - p. 864.e1 101. 27. Sexually Transmitted Infections - p. 865 102. Unit VIII: The Hematologic System - p. 892 103. 28. Structure and Function of the Hematologic System - p. 892a 104. 29. Alterations of Hematologic Function - p. 925 105. Chapter Outline - p. 925 106. Anemia - p. 925 107. Myeloproliferative Red Cell Disorders - p. 939 108. Alterations of Leukocyte Function - p. 942 109. Alterations of Lymphoid Function - p. 957 110. Alterations of Splenic Function - p. 966 111. Hemorrhagic Disorders and Alterations of Platelets and Coagulation - p. 967 112. Summary Review - p. 979 113. References - p. 983 114. 30. Alterations of Hematologic Function in Children - p. 987 115. Unit IX: The Cardiovascular and Lymphatic Systems - p. 1020 116. 31. Structure and Function of the Cardiovascular and Lymphatic Systems - p. 1020a 117. 32. Alterations of Cardiovascular Function - p. 1059 118. Chapter Outline - p. 1059 119. Diseases of the Veins - p. 1059 120. Diseases of the Arteries - p. 1061 121. Disorders of the Heart Wall - p. 1084 122. Manifestations of Heart Disease - p. 1096 123. Summary Review - p. 1102 124. References - p. 1105 125. 33. Alterations of Cardiovascular Function in Children - p. 1109 126. Unit X: The Pulmonary System - p. 1131 127. 34. Structure and Function of the Pulmonary System - p. 1131a 128. 35. Alterations of Pulmonary Function - p. 1153 129. Chapter Outline - p. 1153 130. Clinical Manifestations of Pulmonary Alterations - p. 1153 131. Disorders of the Chest wall and Pleura - p. 1158 132. Pulmonary Disorders - p. 1161 133. Summary Review - p. 1186 134. References - p. 1187 135. 36. Alterations of Pulmonary Function in Children - p. 1191 136. Unit XI: The Renal and Urologic Systems - p. 1211 137. 37. Structure and Function of the Renal and Urologic Systems - p. 1211a 138. 38. Alterations of Renal and Urinary Tract Function - p. 1232 139. 39. Alterations of Renal and Urinary Tract Function in Children - p. 1270 140. Unit XII: The Digestive System - p. 1285 141. 40. Structure and Function of the Digestive System - p. 1285a 142. 41. Alterations of Digestive Function - p. 1318 143. Chapter Outline - p. 1318 144. Disorders of the Gastrointestinal Tract - p. 1318 145. Disorders of the accessory Organs of Digestion - p. 1342 146. Cancer of the Digestive System - p. 1357 147. Summary Review - p. 1366 148. References - p. 1370 149. 42. Alterations of Digestive Function in Children - p. 1375 150. Unit XIII: The Musculoskeletal System - p. 1399 151. 43. Structure and Function of the Musculoskeletal System - p. 1399a 152. 44. Alterations of Musculoskeletal Function - p. 1427 153. Chapter Outline - p. 1427 154. Musculoskeletal Injuries - p. 1427 155. Disorders of Bones - p. 1437 156. Disorders of Joints - p. 1452 157. Disorders of Skeletal Muscle - p. 1462 158. Muscle Tumors - p. 1470 159. Summary Review - p. 1471 160. References - p. 1473 161. 45. Alterations of Musculoskeletal Function in Children - p. 1476 162. Unit XIV: The Integumentary System - p. 1504 163. 46. Structure, Function, and Disorders of the Integument - p. 1504a 164. 47. Alterations of the Integument in Children - p. 1541 165. Unit XV: Multiple Interacting Systems - p. 1557 166. 48. Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults - p. 1557a 167. 49. Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children - p. 1591 168. Glossary - p. 1622 169. Index - p. 1645 170. Common Laboratory Values - p. IBC1
