Microglial Aging: Basic, Translational, and Clinical Advances explores groundbreaking research on microglial function in the context of aging. This comprehensive resource delves into the physiological roles of microglia, the effects of aging on their structure and activity, and their significance in age-related neurodegenerative diseases. With insights from basic, translational, and clinical studies, it provides a thorough understanding of microglial health and its impact on aging. The book discusses how lifestyle choices can enhance microglial functions and prevent neurodegenerative diseases. It covers both pharmacological and non-pharmacological approaches, such as the ketogenic diet, cannabinoids, psychedelics, and non-invasive vagal nerve stimulation.
This text is invaluable for researchers and clinicians focused on improving the quality of life for an aging population.
1. 1: Introduction to microglial aging and its involvement in neurodegenerative diseases - p. S1 2. Chapter 1. Introduction to microglial aging and its involvement in neurodegenerative diseases - p. 3 3. Chapter 2. Involvement of microglial aging in neurodegenerative diseases: a focus on Parkinson’s disease - p. 45 4. Chapter 3. Involvement of microglial aging in neurodegenerative diseases: a focus on multiple sclerosis - p. 67 5. Chapter 4. Involvement of microglial aging in neurodegenerative diseases: a focus on amyotrophic lateral sclerosis - p. 79 6. 2: Outcomes of the lifestyle on microglial aging and neurodegenerative diseases along the aging trajectory - p. S93 7. Chapter 5. Outcomes of the lifestyle on microglial aging and neurodegenerative diseases along the aging trajectory: diet and the gut-brain axis - p. 95 8. Chapter 6. Sleep disturbance as a modulator of microglial morphology and function: implications for neurodegenerative disease - p. 139 9. Chapter 7. The effects of bacterial and viral infections on microglia - p. 171 10. Chapter 8. Physical activity and microglial metabolism in neurodegenerative diseases - p. 203 11. 3: Emerging treatment strategies to rejuvenate microglia in aging and neurodegenerative diseases - p. S223 12. Chapter 9. Microglial senescence and senolytic drugs - p. 225 13. Chapter 10. Cannabinoids as modulators for Alzheimer’s disease: a role for microglia? - p. 271 14. Chapter 11. Psychedelics and microglia in aging: unraveling the secret dialogue behind healthy aging, mental health, and neuroinflammation - p. 293 15. Chapter 12. Effects of plasmalogens on microglial function and neuroinflammation: mechanisms and implications in aging and neurodegenerative diseases - p. 329 16. Epilogue - p. 359 17. Index - p. 361
Microglial Aging: Basic, Translational, and Clinical Advances explores groundbreaking research on microglial function in the context of aging. This comprehensive resource delves into the physiological roles of microglia, the effects of aging on their structure and activity, and their significance in age-related neurodegenerative diseases. With insights from basic, translational, and clinical studies, it provides a thorough understanding of microglial health and its impact on aging. The book discusses how lifestyle choices can enhance microglial functions and prevent neurodegenerative diseases. It covers both pharmacological and non-pharmacological approaches, such as the ketogenic diet, cannabinoids, psychedelics, and non-invasive vagal nerve stimulation.
This text is invaluable for researchers and clinicians focused on improving the quality of life for an aging population.
1. 1: Introduction to microglial aging and its involvement in neurodegenerative diseases - p. S1 2. Chapter 1. Introduction to microglial aging and its involvement in neurodegenerative diseases - p. 3 3. Chapter 2. Involvement of microglial aging in neurodegenerative diseases: a focus on Parkinson’s disease - p. 45 4. Chapter 3. Involvement of microglial aging in neurodegenerative diseases: a focus on multiple sclerosis - p. 67 5. Chapter 4. Involvement of microglial aging in neurodegenerative diseases: a focus on amyotrophic lateral sclerosis - p. 79 6. 2: Outcomes of the lifestyle on microglial aging and neurodegenerative diseases along the aging trajectory - p. S93 7. Chapter 5. Outcomes of the lifestyle on microglial aging and neurodegenerative diseases along the aging trajectory: diet and the gut-brain axis - p. 95 8. Chapter 6. Sleep disturbance as a modulator of microglial morphology and function: implications for neurodegenerative disease - p. 139 9. Chapter 7. The effects of bacterial and viral infections on microglia - p. 171 10. Chapter 8. Physical activity and microglial metabolism in neurodegenerative diseases - p. 203 11. 3: Emerging treatment strategies to rejuvenate microglia in aging and neurodegenerative diseases - p. S223 12. Chapter 9. Microglial senescence and senolytic drugs - p. 225 13. Chapter 10. Cannabinoids as modulators for Alzheimer’s disease: a role for microglia? - p. 271 14. Chapter 11. Psychedelics and microglia in aging: unraveling the secret dialogue behind healthy aging, mental health, and neuroinflammation - p. 293 15. Chapter 12. Effects of plasmalogens on microglial function and neuroinflammation: mechanisms and implications in aging and neurodegenerative diseases - p. 329 16. Epilogue - p. 359 17. Index - p. 361
