Mitochondria and Cancer: From Basic Science to Clinical Applications—Understanding Pathogenesis, Therapy Resistance, and Disease Relapse offers comprehensive perspectives about the role of mitochondria in cancer biology and treatment. This book integrates fundamental scientific knowledge with clinical relevance, presenting recent findings that will engage oncology researchers and provide valuable recommendations for cancer prevention and prognosis. In response to the rising global cancer incidence, this book serves as a comprehensive guide to mitochondrial metabolism in oncology, furthering cancer study and management. It explores a wide range of topics that highlight the multifaceted role of mitochondria in cancer, including tumor microenvironment, cancer stem cells, microbiota, resistance mechanisms, mitochondria-enhancing strategies, and targeted therapies. It includes technical details, research findings, and discussions on the implications of mitochondrial research in cancer treatment and management. Its distinguishing aspects include its comprehensive coverage and diverse perspectives from global experts, providing a well-rounded view of current research.
1. Title of Book - p. i 2. Cover Image - p. i 3. Title Page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Contributors - p. xiii 7. Biography of the editors - p. xv 8. Foreword - p. xvii 9. Preface - p. xix 10. Acknowledgments - p. xxi 11. Chapter 1 Mitochondria: Origin, structure, and function - p. 1 12. Chapter 2 Mitochondrial metabolism and trafficking in cancer - p. 15 13. Chapter 3 Mitochondrial genome and cancer - p. 27 14. Chapter 4 Mitochondrial–nuclear crosstalk and its role in cancer - p. 41 15. Chapter 5 Mitochondria and tumor microenvironment - p. 61 16. Chapter 6 Mitochondria as critical players in cancer stem cells - p. 73 17. Chapter 7 Mitochondria, exosome, cancer - p. 93 18. Chapter 8 Mitochondria, microbiota, and cancer - p. 107 19. Chapter 9 MicroRNAs and their impacts on cancer cell’s mitochondria - p. 119 20. Chapter 10 Mitochondria and cancer prevention - p. 131 21. Chapter 11 Mitochondria and cancer diagnosis - p. 143 22. Chapter 12 Mitochondrial metabolism as a prognostic biomarker - p. 165 23. Chapter 13 Mitochondria and radioresistance - p. 179 24. Chapter 14 Targeting mitochondrial dysfunction: Nanoparticles-mediated approaches to enhance chemotherapy efficacy - p. 189 25. Chapter 15 Mitochondria and resistance to targeted therapies - p. 203 26. Chapter 16 Mitochondria and resistance to immunotherapy - p. 219 27. Chapter 17 Mitochondria-enhancing strategies in cancer treatment - p. 235 28. Chapter 18 Advances in targeted anti-mitochondrial therapies - p. 251 29. Chapter 19 Applying magnetic fields to target mitochondria - p. 263 30. Chapter 20 What the artificial intelligence (AI) proposes for the mitochondria’s role in cancer - p. 273 31. Index - p. 287
Mitochondria and Cancer: From Basic Science to Clinical Applications—Understanding Pathogenesis, Therapy Resistance, and Disease Relapse offers comprehensive perspectives about the role of mitochondria in cancer biology and treatment. This book integrates fundamental scientific knowledge with clinical relevance, presenting recent findings that will engage oncology researchers and provide valuable recommendations for cancer prevention and prognosis. In response to the rising global cancer incidence, this book serves as a comprehensive guide to mitochondrial metabolism in oncology, furthering cancer study and management. It explores a wide range of topics that highlight the multifaceted role of mitochondria in cancer, including tumor microenvironment, cancer stem cells, microbiota, resistance mechanisms, mitochondria-enhancing strategies, and targeted therapies. It includes technical details, research findings, and discussions on the implications of mitochondrial research in cancer treatment and management. Its distinguishing aspects include its comprehensive coverage and diverse perspectives from global experts, providing a well-rounded view of current research.
1. Title of Book - p. i 2. Cover Image - p. i 3. Title Page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Contributors - p. xiii 7. Biography of the editors - p. xv 8. Foreword - p. xvii 9. Preface - p. xix 10. Acknowledgments - p. xxi 11. Chapter 1 Mitochondria: Origin, structure, and function - p. 1 12. Chapter 2 Mitochondrial metabolism and trafficking in cancer - p. 15 13. Chapter 3 Mitochondrial genome and cancer - p. 27 14. Chapter 4 Mitochondrial–nuclear crosstalk and its role in cancer - p. 41 15. Chapter 5 Mitochondria and tumor microenvironment - p. 61 16. Chapter 6 Mitochondria as critical players in cancer stem cells - p. 73 17. Chapter 7 Mitochondria, exosome, cancer - p. 93 18. Chapter 8 Mitochondria, microbiota, and cancer - p. 107 19. Chapter 9 MicroRNAs and their impacts on cancer cell’s mitochondria - p. 119 20. Chapter 10 Mitochondria and cancer prevention - p. 131 21. Chapter 11 Mitochondria and cancer diagnosis - p. 143 22. Chapter 12 Mitochondrial metabolism as a prognostic biomarker - p. 165 23. Chapter 13 Mitochondria and radioresistance - p. 179 24. Chapter 14 Targeting mitochondrial dysfunction: Nanoparticles-mediated approaches to enhance chemotherapy efficacy - p. 189 25. Chapter 15 Mitochondria and resistance to targeted therapies - p. 203 26. Chapter 16 Mitochondria and resistance to immunotherapy - p. 219 27. Chapter 17 Mitochondria-enhancing strategies in cancer treatment - p. 235 28. Chapter 18 Advances in targeted anti-mitochondrial therapies - p. 251 29. Chapter 19 Applying magnetic fields to target mitochondria - p. 263 30. Chapter 20 What the artificial intelligence (AI) proposes for the mitochondria’s role in cancer - p. 273 31. Index - p. 287
