Sinusoidal Cells in Liver Diseases: Role in their Pathophysiology, Diagnosis, and Treatment provides a state-of-the-art review on recent advances surrounding the role of liver sinusoidal cells (LSECs, HSCs, macrophages, and other non-parenchymal cells) in acute and chronic liver diseases. Coverage emphasizes disease pathophysiology, novel mechanisms, unmet clinical questions, development of biomarkers and treatment opportunities. By focusing on the role of sinusoidal cells in human liver diseases, this reference provides a comprehensive overview of the role of sinusoidal cells in acute and chronic liver diseases, in its pathophysiology and mechanisms, and in the development of novel biomarkers and new therapeutics.
Cells of the liver vasculature play an essential role in the pathophysiology of acute and chronic liver diseases and are considered key therapeutic targets to treat most of human hepatopathies. Coverage in this reference includes the phenotypic changes occurring in liver vascular cells and how cells contribute to the development of microcirculatory dysfunction, fibrosis, inflammation, and liver failure.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedication - p. iii 6. Contributors - p. iii 7. About the editor - p. iii 8. Preface - p. iii 9. List of Tables - p. xxii 10. Section I: The liver sinusoid — General concepts - p. xxii 11. Chapter 1: The unique architecture of the hepatic sinusoid - p. xxii 12. Chapter 2: Sinusoidal cell interactions—From soluble factors to exosomes - p. 17 13. Chapter 3: Sinusoidal cells and liver immunology - p. 42 14. Chapter 4: Liver sinusoidal cells in aging - p. 66 15. Chapter 5: Microscopic imaging of hepatic sinusoidal cells: Fifty years in the making - p. 85 16. Chapter 6: The liver sinusoid at single-cell level - p. 104 17. Chapter 7: Advanced models to study liver sinusoids - p. 126 18. Chapter 8: Strategies to target and genetically modify the liver sinusoid - p. 154 19. Section II: The liver sinusoid in acute liver injury - p. 180 20. Chapter 9: Drug-induced liver injury - p. 180 21. Chapter 10: The liver sinusoid in ischemia—reperfusion injury and regeneration - p. 205 22. Chapter 11: Acute bacterial and viral infections - p. 224 23. Section III: The liver sinusoid in chronic liver disease - p. 248 24. Chapter 12: The liver sinusoid in chronic liver disease: NAFLD and NASH - p. 248 25. Chapter 13: Liver Sinusoidal Cells in alcohol-associated liver disease - p. 275 26. Chapter 14: Liver fibrosis - p. 288 27. Chapter 15: Portal hypertension - p. 307 28. Chapter 16: The liver sinusoid in acute-on-chronic liver failure - p. 324 29. Chapter 17: Liver cancer - p. 341 30. Chapter 18: Sinusoidal cells in liver metastasis - p. 357 31. Chapter 19: Cholestatic diseases - p. 378 32. Section IV: The liver sinusoid in other vascular diseases - p. 410 33. Chapter 20: Liver vascular malformations - p. 410 34. Chapter 21: Liver sinusoidal endothelial cells in congestive hepatopathy - p. 431 35. Chapter 22: Porto-sinusoidal vascular disorder - p. 441 36. Section V: Liver sinusoidal cells in the diagnosis and treatment of liver diseases - p. 459 37. Chapter 23: Role of liver sinusoidal endothelial cells in the diagnosis and treatment of liver diseases - p. 459 38. Chapter 24: Role of Kupffer cells and other immune cells - p. 475 39. Chapter 25: Liver sinusoidal cells in the diagnosis and treatment of liver diseases: Role of hepatic stellate cells - p. 499 40. Index - p. 524
Sinusoidal Cells in Liver Diseases: Role in their Pathophysiology, Diagnosis, and Treatment provides a state-of-the-art review on recent advances surrounding the role of liver sinusoidal cells (LSECs, HSCs, macrophages, and other non-parenchymal cells) in acute and chronic liver diseases. Coverage emphasizes disease pathophysiology, novel mechanisms, unmet clinical questions, development of biomarkers and treatment opportunities. By focusing on the role of sinusoidal cells in human liver diseases, this reference provides a comprehensive overview of the role of sinusoidal cells in acute and chronic liver diseases, in its pathophysiology and mechanisms, and in the development of novel biomarkers and new therapeutics.
Cells of the liver vasculature play an essential role in the pathophysiology of acute and chronic liver diseases and are considered key therapeutic targets to treat most of human hepatopathies. Coverage in this reference includes the phenotypic changes occurring in liver vascular cells and how cells contribute to the development of microcirculatory dysfunction, fibrosis, inflammation, and liver failure.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedication - p. iii 6. Contributors - p. iii 7. About the editor - p. iii 8. Preface - p. iii 9. List of Tables - p. xxii 10. Section I: The liver sinusoid — General concepts - p. xxii 11. Chapter 1: The unique architecture of the hepatic sinusoid - p. xxii 12. Chapter 2: Sinusoidal cell interactions—From soluble factors to exosomes - p. 17 13. Chapter 3: Sinusoidal cells and liver immunology - p. 42 14. Chapter 4: Liver sinusoidal cells in aging - p. 66 15. Chapter 5: Microscopic imaging of hepatic sinusoidal cells: Fifty years in the making - p. 85 16. Chapter 6: The liver sinusoid at single-cell level - p. 104 17. Chapter 7: Advanced models to study liver sinusoids - p. 126 18. Chapter 8: Strategies to target and genetically modify the liver sinusoid - p. 154 19. Section II: The liver sinusoid in acute liver injury - p. 180 20. Chapter 9: Drug-induced liver injury - p. 180 21. Chapter 10: The liver sinusoid in ischemia—reperfusion injury and regeneration - p. 205 22. Chapter 11: Acute bacterial and viral infections - p. 224 23. Section III: The liver sinusoid in chronic liver disease - p. 248 24. Chapter 12: The liver sinusoid in chronic liver disease: NAFLD and NASH - p. 248 25. Chapter 13: Liver Sinusoidal Cells in alcohol-associated liver disease - p. 275 26. Chapter 14: Liver fibrosis - p. 288 27. Chapter 15: Portal hypertension - p. 307 28. Chapter 16: The liver sinusoid in acute-on-chronic liver failure - p. 324 29. Chapter 17: Liver cancer - p. 341 30. Chapter 18: Sinusoidal cells in liver metastasis - p. 357 31. Chapter 19: Cholestatic diseases - p. 378 32. Section IV: The liver sinusoid in other vascular diseases - p. 410 33. Chapter 20: Liver vascular malformations - p. 410 34. Chapter 21: Liver sinusoidal endothelial cells in congestive hepatopathy - p. 431 35. Chapter 22: Porto-sinusoidal vascular disorder - p. 441 36. Section V: Liver sinusoidal cells in the diagnosis and treatment of liver diseases - p. 459 37. Chapter 23: Role of liver sinusoidal endothelial cells in the diagnosis and treatment of liver diseases - p. 459 38. Chapter 24: Role of Kupffer cells and other immune cells - p. 475 39. Chapter 25: Liver sinusoidal cells in the diagnosis and treatment of liver diseases: Role of hepatic stellate cells - p. 499 40. Index - p. 524
