Substance Abuse and Addiction Research: Methodology, Mechanisms, and Therapeutics is an up-to-date, comprehensive, practical book on research methodologies for substance abuse and addiction that is intended for researchers and consumers of research information at all levels. The book is divided into four major sections, including an Introduction, Research Methodology for clinical trials, animal research and retrospective studies, Mechanisms of Abuse and Addiction, and Investigative Therapeutics: Designing and Measuring Outcomes. It serves a source for addressing all aspects of research design, methods and analysis within the context of the field of opioids, alcohol and other substances.
The book covers what is known in the field of quantitative and qualitative research methods, provides future directions, and introduces new models for investigation. It is organized around a translational science framework, with the contents addressing substance use/addiction research in the context of epidemiology, etiology, intervention efficacy and effectiveness, and implementation of evidence-informed interventions.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xvii 7. Foreword - p. xxv 8. Part 1: Research methodology for clinical trials, animal research, and retrospective studies - p. xxvi 9. Chapter 1. Reliability and validity in substance misuse and addiction research - p. 3 10. Chapter 2. Animal models - p. 11 11. Chapter 3. Translational research strategies - p. 23 12. Chapter 4. Experimental designs for addiction research - p. 31 13. Chapter 5. Experimental design in clinical trials - p. 55 14. Chapter 6. Qualitative and quantitative research methods - p. 65 15. Chapter 7. Ethical issues in substance misuse and addiction-related research - p. 71 16. Chapter 8. Informatics - p. 91 17. Chapter 9. Artificial intelligence and machine learning - p. 99 18. Chapter 10. Methods for data collection and analysis in epidemiology-of-substance-use research - p. 107 19. Chapter 11. Utility of neuroimaging for substance misuse and addiction research: methodology, mechanisms, and therapeutics - p. 119 20. Chapter 12. Systematic review and meta-analysis - p. 133 21. Part 2: Mechanisms of drug misuse and addiction - p. 142 22. Chapter 13. Misuse and addiction definitions, demographics, and general concepts - p. 147 23. Chapter 14. Assessment of addiction/pain and neurobiology - p. 161 24. Chapter 15. Physiological considerations in opioid addiction - p. 177 25. Chapter 16. Basic pharmacology of opioid substances - p. 185 26. Chapter 17. Basic pharmacology of nonopioid substances - p. 209 27. Chapter 18. Types of addiction - p. 233 28. Chapter 19. Substance misuse - p. 265 29. Chapter 20. Special study populations - p. 275 30. Part 3: Investigative therapeutics: designing and measuring outcomes - p. 284 31. Chapter 21. General therapy strategies in opioid addiction - p. 289 32. Chapter 22. The role of alternative therapies in a comprehensive addiction treatment - p. 309 33. Chapter 23. Drug testing and adherence monitoring - p. 323 34. Chapter 24. Pharmacogenetics: a comprehensive review of genes, genetics, genomics, and epigenetics - p. 333 35. Chapter 25. Medical treatments for opioid use disorder - p. 349 36. Chapter 26. Principles of vaccine development - p. 369 37. Chapter 27. Drug policy analysis - p. 379 38. Chapter 28. Designing and testing population-based prevention programs - p. 389 39. Chapter 29. New vistas in addiction therapy - p. 401 40. Index - p. 411
Substance Abuse and Addiction Research: Methodology, Mechanisms, and Therapeutics is an up-to-date, comprehensive, practical book on research methodologies for substance abuse and addiction that is intended for researchers and consumers of research information at all levels. The book is divided into four major sections, including an Introduction, Research Methodology for clinical trials, animal research and retrospective studies, Mechanisms of Abuse and Addiction, and Investigative Therapeutics: Designing and Measuring Outcomes. It serves a source for addressing all aspects of research design, methods and analysis within the context of the field of opioids, alcohol and other substances.
The book covers what is known in the field of quantitative and qualitative research methods, provides future directions, and introduces new models for investigation. It is organized around a translational science framework, with the contents addressing substance use/addiction research in the context of epidemiology, etiology, intervention efficacy and effectiveness, and implementation of evidence-informed interventions.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xvii 7. Foreword - p. xxv 8. Part 1: Research methodology for clinical trials, animal research, and retrospective studies - p. xxvi 9. Chapter 1. Reliability and validity in substance misuse and addiction research - p. 3 10. Chapter 2. Animal models - p. 11 11. Chapter 3. Translational research strategies - p. 23 12. Chapter 4. Experimental designs for addiction research - p. 31 13. Chapter 5. Experimental design in clinical trials - p. 55 14. Chapter 6. Qualitative and quantitative research methods - p. 65 15. Chapter 7. Ethical issues in substance misuse and addiction-related research - p. 71 16. Chapter 8. Informatics - p. 91 17. Chapter 9. Artificial intelligence and machine learning - p. 99 18. Chapter 10. Methods for data collection and analysis in epidemiology-of-substance-use research - p. 107 19. Chapter 11. Utility of neuroimaging for substance misuse and addiction research: methodology, mechanisms, and therapeutics - p. 119 20. Chapter 12. Systematic review and meta-analysis - p. 133 21. Part 2: Mechanisms of drug misuse and addiction - p. 142 22. Chapter 13. Misuse and addiction definitions, demographics, and general concepts - p. 147 23. Chapter 14. Assessment of addiction/pain and neurobiology - p. 161 24. Chapter 15. Physiological considerations in opioid addiction - p. 177 25. Chapter 16. Basic pharmacology of opioid substances - p. 185 26. Chapter 17. Basic pharmacology of nonopioid substances - p. 209 27. Chapter 18. Types of addiction - p. 233 28. Chapter 19. Substance misuse - p. 265 29. Chapter 20. Special study populations - p. 275 30. Part 3: Investigative therapeutics: designing and measuring outcomes - p. 284 31. Chapter 21. General therapy strategies in opioid addiction - p. 289 32. Chapter 22. The role of alternative therapies in a comprehensive addiction treatment - p. 309 33. Chapter 23. Drug testing and adherence monitoring - p. 323 34. Chapter 24. Pharmacogenetics: a comprehensive review of genes, genetics, genomics, and epigenetics - p. 333 35. Chapter 25. Medical treatments for opioid use disorder - p. 349 36. Chapter 26. Principles of vaccine development - p. 369 37. Chapter 27. Drug policy analysis - p. 379 38. Chapter 28. Designing and testing population-based prevention programs - p. 389 39. Chapter 29. New vistas in addiction therapy - p. 401 40. Index - p. 411
